Rybelsus Drug Interactions
Currently displaying a list of 273 drugs known to interact with Rybelsus (semaglutide).
- 15 major drug interactions
- 257 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with Rybelsus
Note: Showing generic names only.
A
- acetazolamide
- acetohexamide
- albuterol
- alclometasone topical
- aloe vera
- alpelisib
- amcinonide topical
- amprenavir
- anisindione
- aripiprazole
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
B
- bendroflumethiazide
- benzphetamine
- benzthiazide
- betamethasone
- betamethasone topical
- bexarotene
- bortezomib
- brentuximab
- brexpiprazole
- brigatinib
- bumetanide
C
- calaspargase pegol
- cariprazine
- ceritinib
- chlorothiazide
- chlorotrianisene
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chromic chloride hexahydrate
- chromium picolinate
- cinnamon
- cinoxacin
- ciprofloxacin
- clarithromycin
- clobetasol topical
- clocortolone topical
- clozapine
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
D
- daclatasvir
- danazol
- darunavir
- deflazacort
- delafloxacin
- desflurane
- desonide topical
- desoximetasone topical
- dexamethasone
- dexamethasone ophthalmic
- dexamethasone topical
- dexfenfluramine
- diazoxide
- dichlorphenamide
- dicumarol
- dienestrol topical
- diethylpropion
- diethylstilbestrol
- diflorasone topical
- dobutamine
- dopamine
- drospirenone
E
- enflurane
- enfortumab vedotin
- enoxacin
- ephedrine
- epinephrine
- esterified estrogens
- estradiol
- estradiol topical
- estramustine
- estrone
- estropipate
- estropipate topical
- ethacrynic acid
- ethanol
- ethinyl estradiol
- etomidate
- etonogestrel
- everolimus
F
- fenfluramine
- fludrocortisone
- fluocinolone topical
- fluocinonide topical
- fluphenazine
- flurandrenolide topical
- fluticasone topical
- formoterol
- fosamprenavir
- fosphenytoin
- fospropofol
- furosemide
G
H
- halcinonide topical
- halobetasol topical
- haloperidol
- halothane
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroflumethiazide
- hydroxyprogesterone
I
- iloperidone
- inavolisib
- indacaterol
- indapamide
- indinavir
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- isoflurane
- isoniazid
- isoproterenol
K
L
- lanreotide
- leuprolide
- levofloxacin
- levonorgestrel
- levothyroxine
- levothyroxine / liothyronine
- liothyronine
- liotrix
- lithium
- lomefloxacin
- lonapegsomatropin
- loncastuximab tesirine
- lorcaserin
- lumateperone
- lurasidone
M
- ma huang
- mazindol
- medroxyprogesterone
- megestrol
- mephentermine
- mesoridazine
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methazolamide
- methdilazine
- methohexital
- methotrimeprazine
- methoxamine
- methoxyflurane
- methyclothiazide
- methylprednisolone
- methylprednisolone topical
- metolazone
- midostaurin
- mometasone topical
- moxifloxacin
N
- nalidixic acid
- nateglinide
- nelfinavir
- niacin
- niacinamide
- nicotinamide
- nitrous oxide
- norepinephrine
- norethindrone
- norfloxacin
- norgestrel
O
P
- paliperidone
- pasireotide
- pegaspargase
- pegvisomant
- pentamidine
- perphenazine
- phendimetrazine
- phentermine
- phenylephrine
- phenylpropanolamine
- phenytoin
- polythiazide
- prednicarbate topical
- prednisolone
- prednisone
- prochlorperazine
- progesterone
- progesterone topical
- promazine
- promethazine
- propiomazine
- propofol
- pseudoephedrine
Q
R
S
- salmeterol
- saquinavir
- sermorelin
- sevoflurane
- sibutramine
- simeprevir
- sirolimus
- sirolimus protein-bound
- sofosbuvir
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sparfloxacin
- sucralfate
T
- tacrolimus
- tagraxofusp
- temsirolimus
- teprotumumab
- terbutaline
- tesamorelin
- thiethylperazine
- thiopental
- thioridazine
- thyroid desiccated
- thyrotropin alpha
- tipranavir
- tirzepatide
- tolazamide
- tolbutamide
- torsemide
- triamcinolone
- triamcinolone ophthalmic
- triamcinolone topical
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trimeprazine
- triptorelin
- trovafloxacin
- turmeric
V
W
Z
Rybelsus alcohol/food interactions
There are 2 alcohol/food interactions with Rybelsus (semaglutide).
Rybelsus disease interactions
There are 6 disease interactions with Rybelsus (semaglutide) which include:
- suicidal behavior and ideation
- thyroid cancer
- GI adverse events
- hypoglycemia
- pancreatitis
- retinopathy
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More about Rybelsus (semaglutide)
- Rybelsus consumer information
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- Latest FDA alerts (3)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- FDA approval history
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
