Insulin Lispro Protamine and Insulin Lispro (Pens)

Generic name: Insulin Lispro Protamine and Insulin Lispro (Pens) [ IN-soo-lin-LYE-sproe-PROE-ta-meen-& IN-soo-lin-LYE-sproe ]
Brand names: Humalog Mix 50/50, Humalog Mix 75/25
Drug class: Insulin

Medically reviewed by Drugs.com. Last updated on Mar 18, 2024.

Uses of Insulin Lispro Protamine and Insulin Lispro:

• It is used to lower blood sugar in patients with high blood sugar (diabetes).

What do I need to tell my doctor BEFORE I take Insulin Lispro Protamine and Insulin Lispro?

• If you are allergic to insulin lispro protamine and insulin lispro (pens); any part of insulin lispro protamine and insulin lispro (pens); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have low blood sugar.

This is not a list of all drugs or health problems that interact with insulin lispro protamine and insulin lispro (pens).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take insulin lispro protamine and insulin lispro (pens) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Insulin Lispro Protamine and Insulin Lispro?

• Tell all of your health care providers that you take insulin lispro protamine and insulin lispro (pens). This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how insulin lispro protamine and insulin lispro (pens) affects you.
• Allergic reactions have happened with insulin lispro protamine and insulin lispro (pens). Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.
• Low blood sugar may happen with insulin lispro protamine and insulin lispro (pens). Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Talk with the doctor.
• Low blood potassium may happen with insulin lispro protamine and insulin lispro (pens). If not treated, this can lead to a heartbeat that is not normal, very bad breathing problems, and sometimes death. Talk with the doctor.
• Some diabetes drugs like pioglitazone or rosiglitazone may cause heart failure or make it worse in people who already have it. Using insulin with these drugs may increase this risk. If you also take one of these drugs, talk with the doctor.
• Be sure you have the right insulin product. Insulin products come in many containers like vials, cartridges, and pens. Be sure that you know how to measure and get your dose ready. If you have any questions, call your doctor or pharmacist.
• It may be harder to control blood sugar during times of stress such as fever, infection, injury, or surgery. A change in physical activity, exercise, or diet may also affect blood sugar.
• Wear disease medical alert ID (identification).
• Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
• Check your blood sugar as you have been told by your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Talk with your doctor before you drink alcohol or take products that have alcohol in them.
• Do not share your insulin product with another person. This includes any pens, cartridge devices, needles, or syringes, even if the needle has been changed. Sharing may pass infections from one person to another. This includes infections you may not know you have.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Insulin Lispro Protamine and Insulin Lispro) best taken?

Use insulin lispro protamine and insulin lispro (pens) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into the fatty part of the skin in the upper arm, thigh, buttocks, or stomach area.
• If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
• This medicine needs to be mixed before use. Follow how to mix as you were told by the doctor.
• Use right away after mixing.
• Take within 15 minutes before a meal.
• Move site where you give the shot each time.
• Do not give into skin that is thickened, or has pits or lumps.
• Do not give into skin that is irritated, tender, bruised, red, scaly, hard, scarred, or has stretch marks.
• This medicine will look cloudy and milky when ready to use. Do not use if the solution looks clear or has lumps in it. Do not use if powder is stuck to the sides of the container.
• Do not use if the solution is leaking or has particles.
• Do not use if solution changes color.
• Remove all pen needle covers before injecting a dose (there may be 2). If you are not sure what type of pen needle you have or how to use it, talk with the doctor.
• Take off the needle after each shot. Do not store this device with the needle on it.
• This product may make a clicking sound as you prepare the dose. Do not prepare the dose by counting the clicks. Doing so could lead to using the wrong dose.
• Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
• Follow the diet and workout plan that your doctor told you about.
• Be sure you know what to do if you do not eat as much as normal or if you skip a meal.
• Do not mix this insulin in the same syringe with other types of insulin.
• This medicine must not be used in an insulin pump. If you have questions, talk with the doctor.

What do I do if I miss a dose?

• Be sure you know what to do if you forget to take a dose.
• If you are not sure what to do if you miss a dose, call your doctor.

Related/similar drugs

Mounjaro, Ozempic, metformin, Trulicity, Lantus, Tresiba, Basaglar, Levemir, Novolog, Toujeo

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
• Change in eyesight.
• Chills.
• Very bad dizziness or passing out.
• Mood changes.
• Seizures.
• Slurred speech.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Thick skin, pits, or lumps where the injection was given.
• Low blood sugar may occur. Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call the doctor right away if any of these signs occur. Follow what you have been told to do if low blood sugar occurs. This may include taking glucose tablets, liquid glucose, or some fruit juices.

What are some other side effects of Insulin Lispro Protamine and Insulin Lispro?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where the shot is given.
• Weight gain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Insulin Lispro Protamine and Insulin Lispro?

• Store unopened containers in a refrigerator. Do not freeze.
• Do not use if it has been frozen.
• If an unopened container has been stored at room temperature, be sure you know how long you can leave insulin lispro protamine and insulin lispro (pens) at room temperature before you need to throw it away. If you are not sure, talk with the doctor or pharmacist.
• Store opened pens at room temperature. Throw away any part not used after 10 days.
• Protect from heat and light.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about insulin lispro protamine and insulin lispro (pens), please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer