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Gadoteridol Disease Interactions

There are 5 disease interactions with gadoteridol.

Major

GBCAs (applies to gadoteridol) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Hypertension, Diabetes Mellitus

Gadolinium- based contrast agents (GBCAs) such as gadopentetate dimeglumine, gadoteridol and gadodiamide are contraindicated in patients with chronic, severe kidney disease (glomerular filtration rate, GFR < 30 mL/min), or acute kidney injury. GBCAs increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Their use should be avoided in these patients unless the diagnostic information is essential and not available with non- contrasted MRI or other modalities. NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs. Caution is advised in patients at risk for chronically reduced renal function (age >60 years, hypertension or diabetes). Always estimate the glomerular filtration rate (GFR) through laboratory testing.

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Moderate

Gadoteridol (applies to gadoteridol) hemolytic anemia

Moderate Potential Hazard, Moderate plausibility.

Gadoteridol has not been studied in patients with hemolytic anemia and other hemoglobinopathies. The possibility of increased hemolysis has not been excluded. Caution and close monitoring is advised if used on these patients.

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Moderate

Gadoteridol (applies to gadoteridol) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Dose adjustments of gadoteridol in hepatic impairment have not been studied. Therefore, caution should be exercised in patients with hepatic impairment.

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Moderate

Gadoteridol (applies to gadoteridol) seizures

Moderate Potential Hazard, Moderate plausibility.

In patients with a history of grand mal seizures, the possibility to induce such a seizure by gadoteridol is unknown. Caution and close monitoring is advised in patients with a history of seizures.

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Moderate

GBCAs (applies to gadoteridol) allergies

Moderate Potential Hazard, Moderate plausibility.

Severe and fatal hypersensitivity reactions including anaphylaxis have been observed with administration of gadolinium based contrast agents, including gadoteridol. Patients with a history of allergy, drug reactions or other hypersensitivity-like disorders should be closely observed during the procedure and for several hours after drug administration. If a reaction occurs, stop administering and immediately begin appropriate therapy including resuscitation.

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Gadoteridol drug interactions

There are 28 drug interactions with gadoteridol.

Gadoteridol alcohol/food interactions

There is 1 alcohol/food interaction with gadoteridol.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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