Gadoteridol

Generic name: gadoteridol [ GAD-oh-TER-i-dol ]
Brand name: Prohance
Dosage form: intravenous solution (279.3 mg/mL)
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com on Apr 9, 2024. Written by Cerner Multum.

What is gadoteridol?

Gadoteridol is a contrast agent that has magnetic properties. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

Gadoteridol is used to help diagnose certain disorders of the head and neck, or brain and spine (central nervous system).

Gadoteridol may also be used for purposes not listed in this medication guide.

Gadoteridol side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects of gadoteridol may occur up to several days after injection.

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

• burning, itching, swelling, scaling, and tightening or hardening of your skin;

• skin redness or discoloration;

• muscle weakness;

• joint stiffness in your arms, hands, legs, or feet;

• pain; or

• tiredness, trouble moving.

Gadoteridol may cause serious side effects. Call your doctor at once if you have:

• kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

• a seizure (convulsions); or

• a light-headed feeling, like you might pass out.

Common side effects of gadoteridol may include:

• headache;

• nausea; or

• unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. Before receiving gadoteridol, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadoteridol. Also tell your doctor if you have recently received any contrast agents similar to gadoteridol.

Before taking this medicine

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. Ask your doctor about your individual risk.

Gadoteridol can stay in your body for months or years after you receive gadoteridol. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadoteridol if you are allergic to it.

Tell your doctor if you have ever had:

• any type of reaction to a contrast agent;

• diabetes;

• asthma, hay fever, food or drug allergies;

• high blood pressure; or

• kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

How is gadoteridol given?

Gadoteridol is given as an infusion into a vein. A healthcare provider will give you this injection.

You will be watched for a short time to make sure you do not have an allergic reaction.

Gadoteridol dosing information

Usual Adult Dose for CNS Magnetic Resonance Imaging:

Central Nervous System:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min). In patients suspected of having poorly enhancing lesions, in the presence of negative or equivocal scans, a second dose of 0.2 mmol/kg (0.4 mL/kg) may be given up to 30 minutes after the first dose.

Extracranial and Extraspinal Tissues:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min).

Usual Pediatric Dose for CNS Magnetic Resonance Imaging:

Central Nervous System - to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues:
over 2 years of age:
0.1 mmol/kg (0.2 mL/kg) administered as a rapid intravenous infusion (10 mL/min to 60 mL/min) or bolus (greater than 60 mL/min).

Related/similar drugs

Magnevist, Dotarem, gadobutrol, Multihance, Clariscan, gadoterate meglumine

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid after receiving gadoteridol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect gadoteridol?

Other drugs may affect gadoteridol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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