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Medications for Glabellar Lines

Other names: Forehead Lines; Frown Lines

There are two main types of forehead lines. There are the furrows that run horizontally across the forehead, often with a dip or curve in the middle.  These lines or furrows are due to activity of the forehead muscle (frontalis muscle) which lifts the eyebrows when looking upwards and is also used to show facial expressions.  The other type of forehead line is the vertical lines between the eyebrows (glabella lines) which form when we are angry or concentrating, this is due to contracting of corrugator supercilii muscles and procerus muscles.

When the skin is younger the lines are dynamic, which means they are only present when the muscle are being used and then they disappear once the muscles relax.  As the skin ages the dynamic lines progress to become static lines, this means the lines are permanent and are present regardless of whether the muscles are contracting or not.

Lines and wrinkles are an effect of ageing on the skin and therefore have causes beyond our control for example individual genetics, gravity, medical skin conditions, pollution and stress.  Factors that can be managed to help reduce the effect of ageing are reducing sun exposure, not smoking, having a well balanced diet and good skin care.

Drugs used to treat Glabellar Lines

The medications listed below are related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Botox Cosmetic Rate Add review Rx C N
Generic name:
onabotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Jeuveau Rate Add review Rx N
Generic name:
prabotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
onabotulinumtoxinA Rate Add review Rx C N
Generic name:
onabotulinumtoxinA systemic
Brand name:
Botox Cosmetic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
prabotulinumtoxinA Rate Add review Rx N
Generic name:
prabotulinumtoxinA systemic
Brand name:
Jeuveau
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Daxxify 6.5 2 reviews for Daxxify to treat Glabellar Lines Rx N
Generic name:
daxibotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
daxibotulinumtoxinA 6.5 2 reviews for daxibotulinumtoxinA to treat Glabellar Lines Rx N
Generic name:
daxibotulinumtoxinA systemic
Brand name:
Daxxify
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
incobotulinumtoxinA Rate Add review Rx C N
Generic name:
incobotulinumtoxinA systemic
Brand name:
Xeomin
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Xeomin Rate Add review Rx C N
Generic name:
incobotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
letibotulinumtoxinA Rate Add review Rx N
Generic name:
letibotulinumtoxinA systemic
Brand name:
Letybo
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Letybo Rate Add review Rx N
Generic name:
letibotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.