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Daxxify Side Effects

Generic name: daxibotulinumtoxinA

Medically reviewed by Drugs.com. Last updated on Apr 20, 2024.

Note: This document provides detailed information about Daxxify Side Effects associated with daxibotulinumtoxinA. Some dosage forms listed on this page may not apply specifically to the brand name Daxxify.

Applies to daxibotulinumtoxinA: intramuscular powder for solution.

Important warnings This medicine can cause some serious health issues

Intramuscular route (powder for solution)

The effects of all botulinum toxin products, including daxibotulinumtoxinA-lanm, may spread from the area of injection to produce symptoms consistent with botulinum toxin effects.

These symptoms have been reported hours to weeks after injection.

Swallowing and breathing difficulties can be life threatening and there have been reports of death.

The risk of symptoms is probably greatest in children treated for spasticity, an unapproved use for daxibotulinumtoxinA-lanm, but symptoms can also occur in adults, particularly in those patients who have an underlying condition that would predispose them to these symptoms

Common side effects of Daxxify

Some side effects of daxibotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • headache

Incidence not known

  • redness of the skin

Serious side effects of Daxxify

Along with its needed effects, daxibotulinumtoxinA (the active ingredient contained in Daxxify) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking daxibotulinumtoxinA:

Less common side effects

  • drooping upper eyelids
  • partial or slight paralysis of the face

Incidence not known

  • blurred vision
  • change in color vision
  • change in patterns and rhythms of speech
  • chest pain, discomfort, or tightness
  • cough
  • difficulty seeing at night
  • difficulty swallowing
  • dizziness
  • double vision
  • dry eye
  • eye irritation
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling of discomfort
  • fever
  • hives, itching, or skin rash
  • hoarseness
  • increased sensitivity of the eyes to sunlight
  • infection from breathing foreign substance into the lungs
  • joint inflammation
  • loss of bladder control
  • muscle aches and weakness
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing double
  • slurred speech
  • sore throat
  • sweating
  • swollen lymph glands
  • trouble breathing
  • trouble in speaking
  • voice changes
  • vomiting
Managing side effects (general information)

For healthcare professionals

Applies to daxibotulinumtoxinA: intramuscular powder for injection.

General adverse events

The most frequently reported side effects included injection site reactions, headache, eyelid ptosis, facial paresis, muscular weakness, and upper respiratory tract infection.[Ref]

Cardiovascular

Cardiovascular system adverse reactions included arrhythmias and myocardial infarction.[Ref]

Dermatologic

Gastrointestinal

Genitourinary

Immunologic

Treatment emergent binding antibodies were reported to be developed against this drug and RTP004 (amino acid excipient).

Two individuals who previously had botulinum toxin treatment tested positive for neutralizing antibodies.[Ref]

Local

Injection site reactions included injection site pain, injection site erythema, injection site edema, injection site bruising, injection site hematoma, injection site papule, and injection site pruritus.[Ref]

Musculoskeletal

Nervous system

Facial paresis includes facial asymmetry.[Ref]

Ocular

Ophthalmic adverse reactions included dry eye (eye irritation, photophobia, or visual changes).[Ref]

Other

Spread of toxin effect included asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties.[Ref]

Respiratory

Hypersensitivity

Hypersensitivity reactions included anaphylaxis, serum sickness, urticaria, soft tissue edema, and dyspnea.[Ref]

References

1. (2022) "Product Information. Daxxify (daxibotulinumtoxinA)." Revance Therapeutics, Inc., 1

Frequently asked questions

Further information

Daxxify side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer