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Comparing Wellbutrin SR vs Zoloft

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Wellbutrin SR (bupropion) Zoloft (sertraline)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Wellbutrin SR (bupropion) Zoloft (sertraline)
Prescription only

Prescribed for Major Depressive Disorder, Depression. Wellbutrin SR may also be used for purposes not listed in this medication guide.

Prescription only

Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more

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More about Wellbutrin SR (bupropion) More about Zoloft (sertraline)
Ratings & Reviews

Wellbutrin SR has an average rating of 7.2 out of 10 from a total of 146 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 18% reported a negative effect.

Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect.

View all 146 reviews

View all 1972 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Wellbutrin SR side effects

View all Zoloft side effects
Drug Class
Generic Availability

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 60 tablet, extended release
Strength 150 mg/12 hours
Per unit* $8.57
Cost* $514.29

View all Wellbutrin SR prices

Quantity 30 tablet
Strength 100 mg
Per unit* $16.24
Cost* $487.07

View all Zoloft prices

Get free Discount Card

Get free Discount Card

Dosage Forms
  • Oral tablet, extended release
  • Oral concentrate
  • Oral tablet
Brand Names
Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin XL

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

66 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 527 drugs are known to interact with Wellbutrin SR:

  • 217 major drug interactions (949 brand and generic names)
  • 305 moderate drug interactions (1377 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)

A total of 673 drugs are known to interact with Zoloft:

  • 157 major drug interactions (612 brand and generic names)
  • 511 moderate drug interactions (2143 brand and generic names)
  • 5 minor drug interactions (25 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
  • Using sertraline together with alcohol may increase side effects such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

October 04, 1996

December 30, 1991
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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