Zoloft and Nausea: What Users Say

• lil...
• July 2, 2021

For Depression "I promised I would come back and leave a review after trying Zoloft. I am female (21) and I have been diagnosed with depression, anxiety, and post-traumatic stress disorder from a car crash. I read SO many reviews talking about their horrible crazy experiences so I was super scared to try this. I’m on 25mg of Zoloft daily which I believe is the lowest dose. It has worked wonders for me. PLEASE GIVE IT A TRY. The first night I took it without food and I was up all night, extremely nauseous with a crazy amount of energy. Definitely take it in the morning. The only annoying side effects I've experienced are mild nausea if I take it without food and lower libido. This pill has changed my life and honestly saved my life. I am so much more productive and energetic, I no longer have racing thoughts and cry for hours every night. I feel like myself again, and I feel like my best self. I wish you all the best luck on your journey. You are so loved!"

• NP9...
• Taken for 1 to 6 months
• January 12, 2017

For Social Anxiety Disorder "Half the reviews on here are a load of garbage. They range from 'the side effects are too awful' to 'It gives me more anxiety.' Do yourself a favor and do not read to any review from anyone who has taken this drug for less than 8 weeks. If you are serious about reducing your anxiety, then grow some balls and give Zoloft time to work. Yes, you're going to have a number of side effects in the beginning, ranging from drowsiness, nausea, sexual dysfunction, loss of appetite, and even increased anxiety. Guess what, nearly all of these are going to disappear after the first two weeks. In fact, all of the side effects disappeared for me, and it wasn't until around week 8 that I felt the glorious power of this drug. GIVE IT TIME."

• May...
• October 10, 2019

For Obsessive Compulsive Disorder "I’ve dealt with anxiety since I was 22 (now 28). At the start of this year, my anxiety got bad. At my lowest, I decided to make an appointment to see a doctor. I was sobbing after I got off the phone to book the appointment because I felt my anxiety had defeated me. Little did I know that I was finally choosing to take control. I was prescribed 50mg of Zoloft on 4/1/19 and have stayed there. The beginning was rough. I felt jittery, nauseous, and “weird”. It took a month before I started to notice a difference. My generalized anxiety started to fade, and it felt amazing! Intrusive thoughts began to settle down too! I was sleeping better, handling stress better, I could socialize better, overall I had a lot more confidence. I take my pill at the same time every day. I can’t believe how much better I feel today, it can bring me tears. I needed to feel better to see how bad I was. Please don’t be afraid to try it. Give it time! Don’t judge it after 2 or even 3 weeks. Be patient and allow it to work."

• KGr...
• Taken for 1 to 6 months
• October 5, 2018

For Depression "I suffer from SAD, or seasonal affective disorder, depression, and anxiety. All of my symptoms have increased as I've gotten older. Last year I took Lexapro, which was too numbing, affected my executive function, focus, short-term memory, and libido in a bad way. This fall, I decided to be proactive and got on 50 mg of Zoloft. Completely life-changing experience! Side effects were nothing compared to Lexapro. Maybe 1 or 2 days of mild nausea, slight insomnia for the first 2 nights. Now, at 5 weeks, I feel clear, happy, functional, and optimistic. Libido intact. Takes a bit longer to orgasm, but it's kind of amazing because it prolongs the intensity. Zoloft has truly changed my life for the better, hopefully it will continue to work, will take it forever if possible! Wanted to leave this positive review because there are so many negative ones out there, which don't paint an accurate picture of any drug. Negative experiences are always reported more than positive ones. :)"

• Mic...
• Taken for 1 to 6 months
• February 10, 2020

For Depression "This drug saved my life. I started having chronic anxiety and depression very suddenly, and insomnia. I am so thankful for the positive and encouraging reviews on websites like this, because they helped me push through this difficult time, and I hope to do the same for someone else. I agree with many other reviews that it does get worse before it gets better. My anxiety increased at first, I think out of desperation for each day to finally be the day I would feel normal again. But it takes time and patience, and there will be ups and downs. I started seeing improvement around 4 weeks, but took a dive again around week 5 before increasing my dosage. Now I am at about week 7-8 and I would say 90% myself again. I highly recommend doing therapy too, and Xanax has helped curb the increased anxiety while my body adapts. Side effects are minimal, just nausea if I don’t take it with food. Zoloft helped me get my mind back under control and enjoy life again!"

• Lis...
• February 10, 2020

For Social Anxiety Disorder "I am in my 40s and I suffered a panic attack for the first time while driving. My friend said try Zoloft, so I saw the doctor for it. I kept a log first entry dated May 1, 2018. Day 1 on Zoloft: 'I felt tired, a little dizzy, brain fog - woke up a couple of times feeling weird, not myself. I had stomach upset and diarrhea.' Day 2: 'I woke up feeling like a zombie. I was very tired, no emotion, but I had to get up. When I was driving & came to a stoplight, I felt very anxious.' 'I hope I'm making the right decision to start meds but do I have a choice???' Day 3 & 4: '...felt tired, having brain fog. My stomach is rumbling & a little nausea but it is manageable.' Day 8: 'I woke up feeling tired and right now I feel a little anxiety.' Day 17: 'It's been over 2 weeks & I am driving with little to no anxiety!' I have been on Zoloft 25 mg for 2 years now. Because of reading other people's reviews, I knew what to expect & that kept me going!"

• Anx...
• October 4, 2019

For Panic Disorder "I never ever review anything but after being on this drug for now 4 weeks, I felt the need to review. I was previously on Zoloft (25mg) for 2 years before going off of it, and it was AMAZING. 6 months after stopping it, I could feel my anxiety slowly coming back and decided to go back on Zoloft (25mg). The first 3 weeks were horrible. I would wake up every morning with extreme anxiety, nausea/vomiting, and felt really out of it. For those 3 weeks, I had no energy or appetite (lost 10 lbs) which is hard when you need to work and go to school! I was living in a foggy state of 24/7 anxiety and felt like I couldn't escape from it. I knew it was the medicine making it worse, but I wanted to ride it out since I had positive experiences before. FINALLY after 4 weeks, I am starting to feel back to normal. I can get up in the morning without crippling anxiety and dread, attend school, and enjoy my relationship. Please give this medication AT LEAST 6-8 weeks to work. It eventually gets easier!"

• Mir...
• September 9, 2018

For Panic Disorder "I promised myself that I would write a review and try to help someone else if the medicine worked, and boy did it!! This is truly a miracle pill. It helped me with everything, including my panic attacks, anxiety, intrusive thoughts, and OCD rituals. I’m free again, able to live a calm life. I will say the first few weeks were brutal. I had every side effect: nauseous, diarrhea, headaches, dizziness, some minor hair loss, and more. I prayed this pill would help me, and it did. Before it, I had no quality of life and, to me, the side effects were worth it. I stuck it out for 3 months, and I’m back to my old self and even better. I had very dark days. The fear was paralyzing, and I couldn’t function. I couldn’t get through the day without my Xanax 0.25 frequently and now Xanax free! I started with 50mg for a month and then 100mg for 8 weeks. Today, I’m working, exercising, being the mom I want to be, and taking stress better. My panic suffering is over. Thank you Lord and Thank you ZOLOFT!"

• Ano...
• Taken for 1 to 6 months
• January 18, 2022

For Panic Disorder "I promised myself that if this drug made my life better, I would come back to comment on this thread. I'm a 21-year-old male and started Zoloft about 3 months ago after being on Remeron for 4 years for GAD and Panic Disorder. I had no appetite, lost 20 pounds in about 2 weeks, throwing up twice a day, multiple panic attacks, and was in a dark place. My doctor suggested I try Zoloft to which I reluctantly agreed. I was titrated up to 150mg in about a week. My first week was awful. It spiked my anxiety, I felt extremely tense, racing thoughts, nausea, pacing around, etc. The second week I felt extremely numb, emotionless, and just out of it. My least favorite side effect was brain fog. Eight weeks later and I felt amazing, I'm back to my old self but a lot more confident and happy. My advice is don't look at your progress day to day but rather week to week, you'll see the improvement. I came on here every day my first few weeks looking for hope that things would get better, and now they are. :)"

• Jim...
• August 18, 2013

For Obsessive Compulsive Disorder "I went years without getting help until about 8 months ago when I finally broke down, saw a doctor, and was prescribed Zoloft. This pill has given me my life back. I was diagnosed with Obsessive Compulsive Disorder, specifically intrusive/disturbing thoughts and obsessions. This disorder occupied all of my time and energy, to the point where life was unbearable and hopeless. About two weeks after starting Zoloft, there were noticeable improvements. After 6 weeks, I was a different person. Anxiety-0, OCD still there but more of a minor inconvenience than life consuming. Side effects were typical at first: nausea, diarrhea, lightheadedness, and insomnia. All of which subsided after a few weeks. I highly recommend that if you are diagnosed, ask for Zoloft."

• Rin...
• Taken for less than 1 month
• August 9, 2020

For Obsessive Compulsive Disorder "I was suffering from depression my entire life, and I didn't even know it. I'm 32 years old and started taking Zoloft three weeks ago. At first, I suffered from many side effects: insomnia, dizziness, nausea, blurred vision, tired feeling, and even nervousness. It was the worst 10 days of my life. After enduring those 10 days, I was able to look at life differently. I'm able to accept flaws in anything, pardon excuses, laugh with my family and friends comfortably. I can see why people thought I was high maintenance. I was horrible to my family with unrealistic standards."

• Ros...
• Taken for 10 years or more
• September 10, 2019

For Depression "I have been on Zoloft and the generic sertraline on and off for many, many years, on 50 mg. Recently, I developed symptoms of depression, panic, etc., due to health issues. I have a great GP who encourages me to manage my depression, so with his agreement I increased my dose to 100 mg and suffered every symptom for weeks. Anxiety, nausea, shaking, insomnia. After 10 weeks, these symptoms have all but disappeared. After reading all the reviews, I vowed to share my experience too. Remember, the symptoms WILL go away. It may take longer for some people than others to feel better. You may feel good one day but not the next. Hang in there. It takes time. I now feel almost ready to go back to 50 mg."

• MBM...
• June 2, 2020

For Social Anxiety Disorder "I started with Zoloft for GAD and derealization. I started with 25mg for one week and then I upped to 50mg, but the side effects were too bad, so I went back down to 25mg. My God, the beginning was terrible! Anxiety was so much worse, feeling terrified, depressed, feeling guilt, crying, brain fog, and nausea. I lost almost 8kg in 2 weeks because I couldn't eat. My psychiatrist told me to take 0.5mg of Clonazepam until the side effects lift. After exactly 4 weeks, I can say that all the side effects are gone. I feel a bit sleepy, but I am much more calm, no anxiety at all, no guilty feeling. Derealization is still here but much less, and I don't care about her, so she will go away with time too. I went back to work and started socializing again. I take only 1/8 of Clonazepam now. I will up my dose in a few days, but slowly. I PROMISE you that the starting side effects will pass. Trust me! I know how hard it is. This is a reminder for me too if the upping brings back the side effects."

• Sar...
• Taken for 1 to 6 months
• March 20, 2015

For Social Anxiety Disorder "Headaches and a little nausea at the start, now 4 months in, I don't know how I coped before. The anxious 'bad butterflies' that I thought were normal have gone away. Obsessive overthinking and cringing after I got home because what I may have said, has gone away. Feeling almost hyperactive and intense when in a group situation, almost gone. Road rage... work in progress! Hahaha. Sex drive has diminished but this might be a good thing as was obsessive about it before. Less pressure. Wish I had started a lot earlier. Thought my anxiety was part of my personality, but the reality is, without it, I'm back to me again."

• New...
• January 29, 2009

For Depression "I just started Zoloft 3 days ago, and the side effects so far have been very clear. For me, I haven't been able to eat. I've never been a good eater, but I don't need to lose weight, and I am eating maybe half of what I used to just a few days ago. Nothing seems to taste very good, and I feel full after very little food. I get nausea for about 10-15 minutes about 4-5 times a day, that I didn't have before. My head feels really weird, like I can feel the chemicals running through my brain. It's really weird. I had problems sleeping before taking Zoloft, so not sure if that is a side effect. A lot of good reviews - going to stick it out."

• Tre...
• September 6, 2016

For Panic Disorder "Never written a review in my life. Was often on these sites reading people's experiences and hoping 1 day I would be me again. I'm not me, I'm happier than I can remember. When you're used to living with anxiety daily, you don't realize how it actually feels to be 'normal'. Suffered panic attacks at night that came from absolutely nowhere, no warnings or triggers and gradually affected my day-to-day life. Started 50mg, first 2 weeks side effects were pretty harsh: insomnia, increased anxiety, nausea. Was having second thoughts at 4 weeks as didn't see much improvement. Week 5 felt like a switch was turned on in my head. Give this drug 6-8 weeks minimum. It has been life-changing for me."

• Bab...
• March 2, 2017

For Depression "If you are scrolling through 1000's of reviews like I was, this one is for you. I started Zoloft three weeks ago for Major Depression and overwhelming anxiety and panic attacks. I started at 25mg for a week, then up to 50mg. Initially, I felt a million times worse, constant panic attacks, increase in suicidal intrusive thoughts, deep depression. But, after just 1 week at 50mg, I noticed a difference in mood, and it's been better and better since. Fight through the initial worsening of symptoms if you can! I asked for Xanax to help me get through it. It definitely gets worse before it gets better for some people, but it was 100% worth it for me! I also had slight nausea, a sore neck, and some dizziness that all seem to be subsiding."

• Mis...
• April 6, 2020

For Social Anxiety Disorder "Generalized Anxiety Disorder: 24-year-old, never suffered with anxiety, panic attacks, or disturbing intrusive thoughts before - I was terrified, didn’t understand what was going on. I initially took time off work, CBT, counseling, meditation, reiki, and Propranolol to help myself at first. Nothing took it away, so I made the decision to go onto Zoloft. The first 2 weeks, you HAVE to push through the side effects. I was constantly nauseous and at times I would vomit. But now, I’m completely back to my old self! Zoloft has really restored my mental health to the point where I am free of anxiety completely! I’ve also always had terrible PMT since I was a teenager, I have noticed that Zoloft has sorted this out for me too! When that time of the month is approaching usually, I become extremely angry and often cry about irrational things. Since being on Zoloft, I have noticed I am much calmer and happier around my cycle. It’s been like a wonder drug for me!"

• Nik...
• Taken for 1 to 6 months
• October 6, 2019

For Depression "This drug changed my life. I feel better than I ever could have imagined after starting Zoloft. I had suffered with depression, unmedicated, since childhood. Finally, I got a doctor who would give me the antidepressants I needed. I was started on 25 mg for the first week, then 50 mg. I've been on 50 for 5 months now and so far so good. I've noticed drastic changes in my mood and my stress levels. Things that would've sent me into a panic attack before now only get me mildly stressed. I don't have random crying fits anymore. I'm not angry. The main side effect I had upon starting was no appetite. I felt nauseated every time I ate and had no desire to eat either, other than just to stop feeling hungry. That lasted about a month. Other than that, I haven't experienced any negative side effects."

• Kit...
• June 21, 2017

For Depression "20-year-old female, prescribed 50 mg for major depressive disorder, social anxiety, and just overall generalized anxiety. Been on 50 mg for 3 months now. Side effects were minor, which consisted of insomnia, loss of appetite, and nausea, though they subsided within the first few weeks and I now experience none. I love Zoloft! I can live again! I'm laughing and going out with friends, not laying in bed all day. I can finally breathe, my surroundings seem so much brighter, I don't harbor hate anymore, I'm me again. More ambitious and creative like I was before I fell into this self-destructive path of depression two years ago. I no longer have the desire to self-medicate with drugs and alcohol. I wish I got on Zoloft a long time ago."

• Zie...
• September 14, 2018

For Panic Disorder "If you're reading the reviews and thinking how scary Zoloft sounds, or thinking maybe you shouldn’t take it, then you are like I was 6 weeks ago. THIS MEDICINE HAS CHANGED MY LIFE ALREADY. I’m on 50mg and may increase to 75 due to some nervous thoughts and occasional sensations of panic, but it is nothing like it used to be. Before Zoloft, I wasn’t able to leave my house. I was having severe panic attacks multiple times a day. This medicine started working for me at 25mg 2 weeks after starting it. The doctor increased it to 50mg and this week I’ve noticed a huge difference. The only side effect I had was nausea and upset stomach at first, and then again when I increased to 50mg 2 weeks ago. Other than that, I just feel better. Please give this medicine a try if you want a shot at a somewhat normal life. You owe it to yourself to put the fear aside and try to get better. Do this for you. I did, and I was terrified to try it, but I’m so, so happy I did."

• Mea...
• November 7, 2019

For Depression "I’m onto my second box of Zoloft. I took the entire first box over a month at 25mg. I had headaches pretty much every day but they weren’t extreme, just a dull ache. There were also a couple of times where I was feeling nauseous, the pharmacist told me to eat before taking the pill, and that actually helped. So after the first month, I reached my prescribed dose of 50mg daily. No headaches at all now, and no negative side effects at all. My mood is so much better, I actually catch myself laughing at things online or on TV. I am so much more calm and patient with my kids. My husband and I were having huge verbal arguments every couple of days, which I now am capable of refusing to do despite his pushing. I can repeatedly say, 'I’m not going to argue with you,' and stay calm for a long time now, which is obviously new to my husband who is so used to getting a big reaction from me. I honestly feel absolutely fantastic with this medication. Going to ask my doctor about upping my dose for better results!"

• Dyl...
• Taken for 1 to 6 months
• May 20, 2023

For Anxiety and Stress "Unlike a lot of people on here, I was lucky enough to avoid having really any anxiety at all up until about 5 months ago when I suddenly started suffering from the worst health anxiety you can imagine. Every single day for 3-4 months was miserable, all I did was think about my health and check my heart rate and Google my symptoms nonstop. I started Zoloft at the start of April, and let me tell you the first few weeks were hell. Headaches, nausea, increased anxiety, you name it. I read these reviews every single day, only focusing on the ones with positive reviews, and just reading everyone say it eventually gets better was what kept me taking the medicine, or else I would have stopped, but I’m so glad I didn’t. I’m now on about week 7, and I feel better than I have in the last 6 months, most days, my anxiety doesn’t even cross my mind now (and I’m on a very low dose of 50mg). You got this!"

• I...
• December 7, 2012

For Depression "I started using Zoloft on Wednesday the 5th of December 2012. Today's date is the 8th of December 2012. Four days, it has only taken four days for me to feel like a new person. I have been on it before, therefore I know what side effects to expect. Everybody is different, but I suffered from loss of appetite, headaches, nausea, feeling a bit dizzy, lower back pain, and trembling hands. This only lasts for a week or two. I used to cry for no reason (even at work), snap at my partner for stupid things, I was paranoid over everything, socially scared (I always wanted to stay home). I haven't cried since being on Zoloft, nor snapped at my partner. I am a new person now. I'm so happy and look forward to my new life. 100/100."

• Joa...
• Taken for less than 1 month
• August 27, 2019

For Depression "I just recently started taking Zoloft. I've been taking it for almost 3 weeks, so not a long time. But I've so far had a great experience with it! I have postpartum depression and anxiety. It was getting very hard for me to get up during the day with my kids and do stuff. I was tired all the time, no interest in anything or going out. Now, 3 weeks on Zoloft, I have started noticing I have fewer compulsive thoughts, I worry less, and I have been going to see my friends more. I still have to kind of force myself to get out and I still have my days, but it’s been working very well for me. I haven’t had any side effects, which is what I was worried about. I almost didn’t take it because I was so worried and fixated on the side effects. My sex drive hasn’t been affected, and I haven’t been nauseous or anything. I take it at night before bed, and it’s just been really great! I’ll update if any bad side effects happen, but so far it’s great!"