Comparing Trazodone vs Amitriptyline
Trazodone | Amitriptyline |
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Trazodone | Amitriptyline |
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Prescription only
Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more |
Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Related suggestions Depression
Insomnia
Fibromyalgia
Headache
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More about Trazodone | More about Amitriptyline | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Trazodone has an average rating of 6.3 out of 10 from a total of 1404 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect. |
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1765 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: trazodone side effects in more detail. |
See also: amitriptyline side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all trazodone prices |
View all amitriptyline prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
N/A |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
7.5 hours |
16 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 648 drugs are known to interact with trazodone:
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A total of 706 drugs are known to interact with amitriptyline:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
December 24, 1981 |
April 07, 1961 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.