Comparing Amitriptyline vs Trazodone
| Amitriptyline | Trazodone |
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| Amitriptyline | Trazodone |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more |
Related suggestions Depression
Fibromyalgia
Headache
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| More about Amitriptyline | More about Trazodone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Amitriptyline has an average rating of 7.6 out of 10 from a total of 1785 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
Trazodone has an average rating of 6.3 out of 10 from a total of 1412 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Amitriptyline prices |
View all Trazodone prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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16 hours |
7.5 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 709 drugs are known to interact with Amitriptyline:
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A total of 653 drugs are known to interact with Trazodone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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April 07, 1961 |
December 24, 1981 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.