Comparing Amitriptyline vs Fluoxetine
| Amitriptyline | Fluoxetine |
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| Amitriptyline | Fluoxetine |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Fluoxetine may be used for the treatment of certain types of mood disorders and also some eating disorders. It is more likely to cause insomnia than drowsiness. Taking fluoxetine with other... View more |
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| More about Amitriptyline | More about Fluoxetine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Amitriptyline has an average rating of 7.6 out of 10 from a total of 1785 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
Fluoxetine has an average rating of 7.4 out of 10 from a total of 2213 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Amitriptyline prices |
View all Fluoxetine prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Prozac | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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16 hours |
210 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 709 drugs are known to interact with Amitriptyline:
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A total of 677 drugs are known to interact with Fluoxetine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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April 07, 1961 |
December 29, 1987 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.