Comparing Phenergan vs Zofran
| Phenergan (promethazine) | Zofran (ondansetron) |
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| Phenergan (promethazine) | Zofran (ondansetron) |
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Prescription only
Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Sedation is the main side effect. Occasionally, paradoxical reactions (the opposite of what is to be expected) may... View more |
Prescription only
Zofran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, or surgery. It is approved for use in adults and children over the age of 4 and is available as tablets... View more |
Related suggestions Nausea/Vomiting
Popular comparisons
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| More about Phenergan (promethazine) | More about Zofran (ondansetron) | ||||||||
| Ratings & Reviews | |||||||||
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Phenergan has an average rating of 7.4 out of 10 from a total of 151 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 21% reported a negative effect. |
Zofran has an average rating of 8.0 out of 10 from a total of 271 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 15% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Phenergan side effects |
View all Zofran side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
View all Phenergan prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other promethazine brands include: Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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16 hours |
4 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 688 drugs are known to interact with Phenergan:
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A total of 358 drugs are known to interact with Zofran:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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March 29, 1951 |
December 31, 1992 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.