Comparing Methotrexate vs Prednisone
| Methotrexate | Prednisone |
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| Methotrexate | Prednisone |
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Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prednisone effectively controls inflammation and an overactive immune system but may not be suitable for everybody. Long-term use is limited by potentially severe side effects such as adrenal... View more |
Related suggestions Eczema
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| More about Methotrexate | More about Prednisone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
Prednisone has an average rating of 7.6 out of 10 from a total of 857 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 17% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: methotrexate side effects in more detail. |
See also: prednisone side effects in more detail. |
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| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all methotrexate prices |
View all prednisone prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Rayos | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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15 hours |
4 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
Excluding First Trimester
Category D
Positive evidence of risk
First Trimester See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 696 drugs are known to interact with methotrexate:
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A total of 592 drugs are known to interact with prednisone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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December 07, 1953 |
February 21, 1955 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
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| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.