Comparing Lyrica vs Zoloft
| Lyrica (pregabalin) | Zoloft (sertraline) |
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| Lyrica (pregabalin) | Zoloft (sertraline) |
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Prescription only
Lyrica can help relieve nerve pain and control seizures but it is likely to cause drowsiness. Prescribed for Neuropathic Pain, Neuralgia, Fibromyalgia, Diabetic Peripheral Neuropathy, Postherpetic... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
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| More about Lyrica (pregabalin) | More about Zoloft (sertraline) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Lyrica has an average rating of 6.4 out of 10 from a total of 925 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 26% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Lyrica side effects |
View all Zoloft side effects |
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| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Lyrica prices |
View all Zoloft prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other pregabalin brands include: Lyrica CR |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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6.3 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 284 drugs are known to interact with Lyrica:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 30, 2004 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.