Comparing Januvia vs Semaglutide

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Januvia (sitagliptin)	Semaglutide	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Januvia (sitagliptin)	Semaglutide	Enter another drug to compare
Prescription only Januvia is a DPP-4 inhibitor that is used in addition to other medications for the treatment of type 2 diabetes. Rarely, it may cause joint pain, skin reactions, pancreatitis, or an allergic... View more	Prescription only Semaglutide (Ozempic, Rybelsus) lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the... View more	Related suggestions Type 2 Diabetes Metformin Ozempic Rybelsus Mounjaro Tirzepatide Victoza Popular comparisons Januvia vs Ozempic Januvia vs metformin Januvia vs Jardiance Januvia vs Rybelsus Januvia vs Trulicity
More about Januvia (sitagliptin)	More about Semaglutide
Ratings & Reviews
Januvia has an average rating of 4.5 out of 10 from a total of 139 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 53% reported a negative effect.	Semaglutide has an average rating of 6.9 out of 10 from a total of 2583 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative effect.
View all 139 reviews	View all 2583 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Diarrhea (11.5%) Joint pain (8.6%) Nausea (7.9%) Upset stomach (6.5%) Shortness of breath (5.8%) Swelling (5.8%) Vomiting (5.8%) View all Januvia side effects	Nausea (33.7%) Diarrhea (14.9%) Constipation (14.9%) Vomiting (11.1%) Burping (6.7%) Headaches (6.5%) Upset stomach (6.0%) View all Semaglutide side effects
Drug Class
Dipeptidyl peptidase 4 inhibitors	GLP-1 Agonists (Incretin Mimetics)
Generic Availability
No lower cost generic approved	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet	N/A
Brand Names
Other sitagliptin brands include: Brynovin, Zituvio	Ozempic, Rybelsus, Wegovy
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
12.4 hours	168 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
B Category B No proven risk in humans See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.
Drug Interactions
A total of 295 drugs are known to interact with Januvia: 2 major drug interactions (5 brand and generic names) 288 moderate drug interactions (1517 brand and generic names) 5 minor drug interactions (24 brand and generic names)	A total of 273 drugs are known to interact with Semaglutide: 15 major drug interactions (34 brand and generic names) 257 moderate drug interactions (1451 brand and generic names) 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more	Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
Renal dysfunction Pancreatitis Heart failure Liver dysfunction	Suicidal behavior and ideation Thyroid cancer GI adverse events Hypoglycemia Pancreatitis Retinopathy
First Approval Date
October 16, 2006	December 05, 2017
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pricing and coupons Pregnancy warnings Breastfeeding warnings Drug images Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Support group En español
Patient Resources
Januvia uses	Semaglutide uses
Professional Resources
Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Type 2 Diabetes	Weight Loss (Obesity/Overweight) Cardiovascular Risk Reduction Chronic Kidney Disease Type 2 Diabetes

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Comparing Januvia vs Semaglutide

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