Guaifenesin / phenylpropanolamine Alternatives Compared
| Guaifenesin / phenylpropanolamine | Benadryl (diphenhydramine) | Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) |
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| Guaifenesin / phenylpropanolamine | Benadryl (diphenhydramine) | Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) |
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Prescription and OTC
Prescribed for Cold Symptoms, Cough and Nasal Congestion. Guaifenesin / phenylpropanolamine may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more |
Over-the-counter
Prescribed for Cough, Cold Symptoms. Vicks NyQuil Cold & Flu Nighttime Relief may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Benadryl (diphenhydramine) | More about Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) | |||||||||
| Ratings & Reviews | ||||||||||
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Be the first to share your experience with this drug. |
Benadryl has an average rating of 7.2 out of 10 from a total of 78 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect. |
Vicks NyQuil Cold & Flu Nighttime Relief has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect. |
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| Side Effects | ||||||||||
| Generic Availability | ||||||||||
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N/A |
N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Benadryl prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms Available | ||||||||||
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N/A |
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N/A |
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| Brand Names | ||||||||||
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Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other acetaminophen / dextromethorphan / doxylamine brands include: Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Clear Cough PM Multi-Symptom, Contac Cold + Flu (Night) Cooling Relief Liquid, Coricidin HBP Nighttime Multi-Symptom Cold, Delsym Night Time Cough & Cold, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime, Tylenol Cough & Sore Throat Nightime, Vicks Nature Fusion Cold & Flu Nighttime Relief, Vicks NyQuil HBP Cold & Flu View more | ||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||
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6.6 hours |
9.3 hours |
N/A |
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| CSA Schedule ** View glossary of terms | ||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category N
Not classified
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| Drug Interactions | ||||||||||
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A total of 192 drugs are known to interact with Guaifenesin / phenylpropanolamine:
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A total of 451 drugs are known to interact with Benadryl:
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A total of 496 drugs are known to interact with Vicks NyQuil Cold & Flu Nighttime Relief:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||
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| Disease Interactions | ||||||||||
| First Approval Date | ||||||||||
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N/A |
March 04, 1946 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||
| Patient resources | ||||||||||
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| Professional Resources | ||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.