Comparing Estrace Vaginal Cream vs Premarin
| Estrace Vaginal Cream (estradiol) | Premarin (conjugated estrogens) |
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| Estrace Vaginal Cream (estradiol) | Premarin (conjugated estrogens) |
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Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis. Estrace Vaginal Cream may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Atrophic Vaginitis, Abnormal Uterine Bleeding, Atrophic Urethritis, Breast Cancer - Palliative, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian... View more |
Related suggestions Atrophic Vaginitis
Atrophic Urethritis
Popular comparisons
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| More about Estrace Vaginal Cream (estradiol) | More about Premarin (conjugated estrogens) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Estrace Vaginal Cream has an average rating of 6.6 out of 10 from a total of 82 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 22% reported a negative effect. |
Premarin has an average rating of 7.7 out of 10 from a total of 84 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 17% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Estrace Vaginal Cream side effects |
View all Premarin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Lower cost generic approved | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Estrace Vaginal Cream prices |
View all Premarin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other estradiol brands include: Estring, Imvexxy, Vagifem, Yuvafem | Other conjugated estrogens brands include: Premarin Intravenous | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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N/A |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 244 drugs are known to interact with Estrace Vaginal Cream:
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A total of 256 drugs are known to interact with Premarin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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January 31, 1984 |
May 08, 1942 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.