Estrace Vaginal Cream and Itching: What Users Say

• Ell...
• Taken for 2 to 5 years
• September 21, 2020

For Atrophic Vaginitis "Horrible itching, burning, swelling from any topical estrogen I tried - Estrace, Vagifem, Premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - VERSABASE is hypoallergenic. I AM CURED - the compounded Estriol in VERSABASE has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use Estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!"

• Sar...
• Taken for less than 1 month
• December 30, 2019

For Atrophic Vaginitis "I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also, Allergan offered free applicators but Mylan won’t even answer an email regarding this. I think it's very unsanitary to expect one to reuse the tubes. Allergan won’t even respond when I asked if I could buy the applicators for the generic. I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand?"

• men...
• August 10, 2018

For Atrophic Vaginitis "This cream has been a miracle. I had a hysterectomy 20 years ago and have been off estrogens for at least 15 years. About five years ago started having all kinds of vaginal discomfort. I think I was also battling a bacterial infection. Tried everything for that too. Finally settled on using boric acid capsules once a week for quite some time and the Estrace three times a week. I used about 1 gram. After several months, finally I was able to stop the boric acid. I also was able to cut my Estrace back to once a week 1 gram. Before using this, I was so sensitive that I would be burning and itching just from wiping with toilet paper. The tissue was so thin it looked shriveled up down there. I noticed I had what appeared to be blood blisters on my labia, which have gone away. The skin has plumped up too and is so much healthier. I would give this a ten except the cost is ridiculous."

• Cas...
• Taken for less than 1 month
• September 14, 2019

For Atrophic Vaginitis "I tried 1 gram of Estrace 4 days in a row. I had extreme dryness prior to taking it. It corrected that, however, I experienced itching, burning, and several trips to the bathroom at night to urinate. I am through with it!"

• Anonymous
• September 14, 2011

"I am a 54-year-old postmenopausal woman and have been using Estrace cream 1 mg every night for about a month for vaginal dryness. All of a sudden, I am experiencing itching and burning. I wonder if I have an infection from this cream."

• Anonymous
• Taken for 2 to 5 years
• April 19, 2023

For Atrophic Vaginitis "I have been using the generic brand Estrace, 1g twice a week for three and a half years to alleviate the symptoms of vaginal atrophy caused by menopause, including dryness, burning, and itching. Initially, sex was comfortable until my husband's low testosterone and low libido issues caused a significant decrease in our sexual activity. As a result, my vagina has narrowed and shortened due to lack of use, causing painful intercourse, despite continuing the use of Estrace. I plan to increase my Estrace dosage for a few weeks to address these changes and improve the discomfort during sex. It is ironic that my husband's low libido has led to my discomfort, which now irritates him. Technically, it is his fault that we did not engage in sexual activity regularly, leading to these issues."

• Cec...
• Taken for 1 to 6 months
• January 23, 2021

For Atrophic Vaginitis "My doctor prescribed a low dosage of Estrace Cream twice a week for frequent UTIs. Right off, I got severe itching but gave it time to go away, then got breast tenderness and pelvic pain. Been on it for almost 3 months. I haven't had a UTI, however, what side effects I have-not to mention the cost. Going to quit using it. I will figure a way to control the UTIs. Not worth dealing with the side effects."