Comparing Caffeine vs Nicotine
| Caffeine | Nicotine |
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| Caffeine | Nicotine |
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Prescription and OTC
Prescribed for Drowsiness, Apnea of Prematurity, Asthma. Caffeine may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Prescribed for Smoking Cessation. Nicotine may also be used for purposes not listed in this medication guide. |
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| More about Caffeine | More about Nicotine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Caffeine has an average rating of 6.7 out of 10 from a total of 39 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 28% reported a negative effect. |
Nicotine has an average rating of 7.6 out of 10 from a total of 202 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Caffeine side effects |
View all Nicotine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Caffeine prices |
View all Nicotine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| 357 HR Magnum, Alert, Cafcit, Caffedrine, ConRx Alert, Diurex Maximum Relief Water Caps, Diurex Ultra, Enerjets, Fastlene, Jet Alert Double Strength, Jet Alert Maximum Strength, Jet Alert Regular Strength, Keep Going, Molie, NoDoz, Overtime, Pep-Back ReCharge, Pep-Back Ultra, Stay Awake, Valentine, Vivarin View more | Commit, Habitrol, Leader Nicotine Polacrilex, Nicoderm CQ, Nicorette, Nicorette DS, Nicotrol Inhaler, Nicotrol NS | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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4 hours |
4 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
Caffeine Citrate Injection
Category N
Not classified
Excluding Caffeine Citrate Injection See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 107 drugs are known to interact with Caffeine:
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A total of 33 drugs are known to interact with Nicotine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 21, 1999 |
January 13, 1984 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.