Comparing Buprenorphine vs Methadone
| Buprenorphine | Methadone |
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| Buprenorphine | Methadone |
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Prescription only
Buprenorphine is a potent analgesic that should be only used to treat moderate to severe pain or for the treatment of opioid addiction under strict conditions. Different formulations of the drug... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions |
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| More about Buprenorphine | More about Methadone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Buprenorphine has an average rating of 6.7 out of 10 from a total of 1147 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 25% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 606 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 6% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Buprenorphine side effects |
View all Methadone side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Buprenorphine prices |
View all Methadone prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Belbuca, Brixadi, Buprenex, Butrans, Sublocade | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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48 hours |
30 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 716 drugs are known to interact with Buprenorphine:
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A total of 835 drugs are known to interact with Methadone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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December 29, 1981 |
August 13, 1947 |
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| WADA Class View classifications | |||||||||||||||||
| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.