Methadone Interactions
There are 835 drugs known to interact with methadone, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 420 are major, 406 are moderate, and 9 are minor.
- View all 835 medications that may interact with methadone
- View methadone alcohol/food interactions (1)
- View methadone disease interactions (16)
Most frequently checked interactions
View interaction reports for methadone and the medicines listed below.
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Dilaudid (hydromorphone)
- Flexeril (cyclobenzaprine)
- Klonopin (clonazepam)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- MiraLAX (polyethylene glycol 3350)
- Neurontin (gabapentin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- OxyContin (oxycodone)
- Phenergan (promethazine)
- Prilosec (omeprazole)
- Prozac (fluoxetine)
- Seroquel (quetiapine)
- Soma (carisoprodol)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Valium (diazepam)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
Methadone alcohol/food interactions
There is 1 alcohol/food interaction with methadone.
Methadone disease interactions
There are 16 disease interactions with methadone which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
