Comparing Benadryl vs Tylenol Cold
| Benadryl (diphenhydramine) | Tylenol Cold (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine) |
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| Benadryl (diphenhydramine) | Tylenol Cold (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine) |
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Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Over-the-counter
Prescribed for Influenza, Cold Symptoms. Tylenol Cold may also be used for purposes not listed in this medication guide. |
Related suggestions Cold Symptoms
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| More about Benadryl (diphenhydramine) | More about Tylenol Cold (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine) | ||||||||
| Ratings & Reviews | |||||||||
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Benadryl has an average rating of 7.0 out of 10 from a total of 79 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
Tylenol Cold has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Benadryl side effects |
View all Tylenol Cold side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all Benadryl prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
| Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine brands include: Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Allpanto-S, Childrens Tylenol Cold Plus Cough, Co-Apap, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Day and Night, Contac Cold and Flu Maximum Strength, Cough Formula M Multi-Symptom, Genacol Maximum Strength, Theracaps Multi-Symptom Cough & Cold Reliever, Triaminic Flu, Cough & Fever View more | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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9.3 hours |
30 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category N
Not classified
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| Drug Interactions | |||||||||
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A total of 448 drugs are known to interact with Benadryl:
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A total of 688 drugs are known to interact with Tylenol Cold:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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March 04, 1946 |
N/A |
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| WADA Class View classifications | |||||||||
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N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
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N/A |
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| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.