Comparing Benadryl vs Mucinex
| Benadryl (diphenhydramine) | Mucinex (guaifenesin) |
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| Benadryl (diphenhydramine) | Mucinex (guaifenesin) |
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Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Prescription and OTC
Mucinex is an expectorant that helps thin mucus allowing it to be more easily cleared by coughing. It may also be used off-label to increase fertility in women with hostile mucus as the cause of... View more |
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| More about Benadryl (diphenhydramine) | More about Mucinex (guaifenesin) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Benadryl has an average rating of 7.0 out of 10 from a total of 79 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
Mucinex has an average rating of 6.2 out of 10 from a total of 155 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 34% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Benadryl side effects |
View all Mucinex side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Benadryl prices |
View all Mucinex prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other guaifenesin brands include: Air Power, Allfen Jr, Altarussin, Altorant, Amibid LA, Anti-Tuss, Aquamist, Balminil Expectorant, Beechams Veno's Expectorant, Beechams Veno's for Kids Chesty Cough, Benadryl Chesty Forte, Benylin E, Bidex-400, Breonesin, Bronchoril, Buckley's Chest Congestion, Calmylin Expectorant, Diabetic Expectorant, Diabetic Tuss, Diabetic Tussin Chest Congestion, Diabetic Tussin Mucus Relief, Dristan Chesty Cough, Dristan Chesty Cough Guaiphenesin, Drituss G, Duratuss G, Family Meltus Chesty Coughs, Fenesin, Fenesin IR, Fenex-LA, G Bid, Ganidin NR, Genatuss, GG 200 NR, GG-Cen, Giltuss Children's EX Expectorant, Giltuss EX Expectorant, Glytuss, Gua-SR, Guaiatussin, Guaibid-LA, Guaifen NR, Guaifenesin LA, Guaifenex G, Guaifenex LA, Guiacough, Guiadrine G-1200, Guiatuss, Help I Have Chest Congestion, Hill's Balsam Chesty Cough, Humavent LA, Humibid, Humibid E, Humibid Pediatric, Humigen LA, Hytuss, Junior Meltus Chesty Coughs with Catarrh, Junior Meltus Colour and Sugar Free Expectorant, Lemsip Cough Chesty, Mucaplex, Mucinex Children's Chest Congestion, Mucinex for Kids, Mucinex Maximum Strength, Mucobid-LA, Organ-1 NR, Refenesen Chest Congestion Relief, Robafen, Robitussin Mucus + Chest Congestion, Rompe Pecho EX, Scot-Tussin Expectorant, Siltuss DAS, Siltussin DAS, Siltussin DAS-NA, TabTussin 400, Tussin Expectorant, Tussin Mucus + Chest Congestion, Xpect View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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9.3 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 448 drugs are known to interact with Benadryl:
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No known drug interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||||||||||
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March 04, 1946 |
July 12, 2002 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.