Alendronate Alternatives Compared
| Alendronate | Calcium / vitamin d | Prolia (denosumab) |
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| Alendronate | Calcium / vitamin d | Prolia (denosumab) |
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Prescription only
Alendronate helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a... View more |
Over-the-counter
Prescribed for Osteoporosis, Dietary Supplementation. Calcium / vitamin d may also be used for purposes not listed in this medication guide. |
Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Related suggestions |
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| More about Alendronate | More about Calcium / vitamin d | More about Prolia (denosumab) | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Alendronate has an average rating of 2.8 out of 10 from a total of 185 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 78% reported a negative effect. |
Calcium / vitamin d has an average rating of 7.5 out of 10 from a total of 12 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 8% reported a negative effect. |
Prolia has an average rating of 2.9 out of 10 from a total of 374 ratings on Drugs.com. 16% of reviewers reported a positive effect, while 76% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Alendronate side effects |
View all Calcium / vitamin d side effects |
View all Prolia side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all Alendronate prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Prolia prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Binosto, Fosamax | Calcarb with D, Calcet, Calcet Petites, Calcio Del Mar, Calcitrate with D, Calcium 600 D, Caltrate 600 with D Plus Soy, Caltrate 600+D, Caltrate Colon Health, Caltrate Gummy Bites, Caltro with Vitamin D, Calvite P, Chewable Calcium with Vitamin D, Citracal + D, Citracal Calcium Gummies, Citracal Calcium Pearls, Citracal Maximum, Citracal Petites, Citracal Plus Heart Health, Citracal Regular, Citracal Regular 250 mg + D, Citracal Slow Release 1200, Citrus Calcium with Vitamin D, Dical Captabs, Dical-D, Dicalphos plus D, Os-Cal 500 Chewable, Os-Cal Calcium+D3, Os-Cal Extra D3, Oysco 500 with D, Oyster Shell Calcium with Vitamin D, Oyster-D, Oystercal-D, Posture-D H/P, Risacal-D, UPCal D, Wellesse Liquid Calcium with Vitamin D View more | Other denosumab brands include: Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Stoboclo, Wyost, Xbryk, Xgeva View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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N/A |
N/A |
609.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 117 drugs are known to interact with Alendronate:
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A total of 283 drugs are known to interact with Calcium / vitamin d:
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A total of 306 drugs are known to interact with Prolia:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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September 29, 1995 |
N/A |
June 01, 2010 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.