Comparing 5-HTP vs Zoloft
5-HTP | Zoloft |
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5-HTP (5-hydroxytryptophan) | Zoloft (sertraline) |
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Over-the-counter
Used for ADHD, Anxiety, Insomnia, Headache. 5-HTP may also be used for purposes not listed in this medication guide. |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
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More about 5-HTP (5-hydroxytryptophan) | More about Zoloft (sertraline) | ||||||||
Ratings & Reviews | |||||||||
5-HTP has an average rating of 6.5 out of 10 from a total of 155 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Zoloft has an average rating of 7.2 out of 10 from a total of 1942 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: 5-HTP side effects in more detail. |
See also: Zoloft side effects in more detail. |
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Generic Availability | |||||||||
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoloft prices |
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Dosage Forms Available | |||||||||
N/A |
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Brand Names | |||||||||
N/A |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
4 hours |
66 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category N
Not classified
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 97 drugs are known to interact with 5-HTP:
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A total of 657 drugs are known to interact with Zoloft:
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Alcohol/Food/Lifestyle Interactions | |||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||
No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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First Approval Date | |||||||||
N/A |
December 30, 1991 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.