Vortioxetine for Major Depressive Disorder User Reviews (Page 5)

• Aug...
• Taken for less than 1 month
• November 13, 2018

Vortioxetine "I have been taking 10 mg for a week and no side effects whatsoever. For the first time in years, I am sleeping through the night (I take it at bedtime) and wake up rested. It's not meant to be a sleep aide, but it certainly is a nice side effect. With my anxiety and depression, I'm usually up at 2:00 am and wandering around my house for a few hours, so this is a welcome change. I'm only seeing a marginal increase in my depression, but I suspect, being that I am tolerating it very well, I will get bumped up to a higher dose. The only potential side effect (I say potential because it's only been a week) is that my appetite is not as good as normal (forgetting to eat meals and when I do, I feel full much quicker). I will update as I move up in dosage."

• Bec...
• Taken for less than 1 month
• February 28, 2024

"I have refractory MDD and have been on a lot of different antidepressants. SSRIs were of little use, SNRIs seemed to work fine, and an adjunct of quetiapine was useful. Sadly, after a year, I relapsed again and was started on vortioxetine. It made a HUGE difference. I went from actively suicidal to feeling 20 years younger in a few weeks. The main problem, like SNRIs, is that it causes sexual dysfunction. In my case, lowering my dose to 10mg helped, but also meant I retained some sexual function. For me, this was a very good antidepressant, although I cannot comment on its long-term effects. Certainly, 3 weeks has made a huge difference."

• JC2...
• January 21, 2019

Vortioxetine "I’ve been on Trintellix 10 mg daily for about four years; this last spring of ‘18, I upped to 20 mg. I felt my depression was getting bad again. I did see improvements with the higher dosage. I also take Propranolol daily for anxiety, which has helped significantly. In the last three months, my depression and anxiety symptoms have returned almost full force. I just started reading about side effects with both meds and am putting some important pieces together. Within six months of beginning Trintellix, I began experiencing constipation, stomach pains, and mild joint pain. The symptoms were so bad, my doctor had my gallbladder removed. Nothing has changed. Now, I can’t help but connect the symptoms to Trintellix-can’t be 100% sure, though. Trintellix served me well for a period of time, but as usual, I’ve developed a resistance and need to search out another option. I hope this is helpful to those looking for more info on the possible use of this Rx."

• Anonymous
• Taken for less than 1 month
• October 17, 2017

Vortioxetine "If you have been struggling with unsuccessful medications for years, you need to go get genetic testing. Do it. This is a fairly recent development, which I just found out about two months ago, after taking various medications for depression and anxiety for 15 years. My genetic test results indicate that I have 4 gene mutations that make the use of SSRIs and SNRIs ineffective. And of course, those are the medications I have been taking since the onset of my depression. So I am making the switch to Trintellix. Too early to say if this will be the right medication for me, but it is a comfort to know I am at least now working with my genetics instead of against them. Genetic testing is not the silver bullet, but it is valuable data. Do it."

• Sco...
• Taken for 6 months to 1 year
• November 30, 2023

Vortioxetine "So I was on it about a year ago for major depression. At the time of starting it, I was a borderline alcoholic. It helped with my issues but ended up giving me migraines, so I stopped. But besides that, I still don't drink alcohol. I miss drinking, but when I take a sip of any alcoholic beverage, I end up throwing it away. I'm blaming the Trintellix, but in a good way. I don't wake up every day wanting to drink, but I'm still depressed, which sucks. At least I'm not numbing myself by drinking. It definitely gave me a sense of happiness. I do miss taking it for the most part, just the migraines I got were the worst. It was 10mg pills."

• hbe...
• Taken for 1 to 6 months
• May 14, 2015

Vortioxetine "I only stopped taking this medication because I switched insurances, and the new company will not cover it at all! Being off of it, I realize what a huge difference this medication made. I took Trintellix for 4 months. I had some difficulty the first couple of weeks, to be honest, with sleep. Taking the medication in the evening made sense for me, I slept better versus taking it during the daytime, I slept worse. I ended up not needing to take any of my anti-anxiety pills after a month! My arousal was not hindered at all. Brilliant medication, thank you to whoever discovered this one."

• Lea...
• Taken for 1 to 6 months
• February 12, 2020

Vortioxetine "After 2+ months on Trintellix (10 mg), I am weaning myself off as quickly as possible. The side effects have been almost unbearable for me and my family. Daily feelings of nausea and frequent vomiting were bad enough, but the significant irritability and difficulty getting a deep breath were increasing and were the final straw for me! I ended up in the ER 3 weeks ago because I was struggling to get a deep breath. After thorough testing, it was determined nothing was wrong. A deep search on Trintellix side effects made it clear the problem was this medication. I am now taking it every other day until next week when I meet with my doctor. I hope no one else responds to this drug as badly as I did! Take care! I definitely received no improvement in my depression and only major side effects that I can't live with."

• Tra...
• Taken for 6 months to 1 year
• September 6, 2017

Vortioxetine "I've been on Trintellix 20 mg for 10 months, 53-year-old female with long-standing, chronic MDD and anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times, and in my 30s, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; it hasn't been a 'miracle' drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, and 10 mg Adderall daily."

• Amb...
• Taken for 1 to 6 months
• June 20, 2025

Vortioxetine "I have taken several antidepressants, all of which made me anxious and gave me insomnia. Found a new psychiatrist who started me on Trintellix. The first two weeks I felt great, no side effects except for feeling sedated. I welcomed it though because I no longer had panic attacks and felt really calm and neutral. After an increase from 5 to 10 mg I feel great. I still have feelings but I’m not sad or anxious. No sexual side effects. This medication really changed my life."

• Ron...
• Taken for 1 to 2 years
• April 8, 2024

Vortioxetine "I was taking 20mg of this medication, and it was excellent for stabilizing my mood. I even stopped worrying about the future. However, I had to stop using Trintellix because it disrupted my sleep patterns so much. I used to be a night owl (bad for mental health)."

• Fem...
• Taken for 6 months to 1 year
• March 26, 2017

Vortioxetine "I took all sorts of meds to test with the most horrible side effects. Finally, one day, my doc had me try Trintellix 20 mg, and my life changed. I read negative reviews and was scared, but I have had no side effects except for some weight gain. I had a family member that got severely sick, and I was by their bedside for 3 months. Though I would get depressed, I never had a dark dip (you know what I'm talking about), I bounced back quickly. I recommend trying this. Just try, and in a week you will know. The drug is super expensive. Use a coupon. Call the pharma company. See what happens... it may just change your life. Oh... I forgot to mention that I just started my own business after years of working for idiots and getting fired. I doubt I could do this without this med."

• Dee...
• Taken for less than 1 month
• July 3, 2019

Vortioxetine "I have switched to Trintellix about 2 weeks ago from Celexa, which I had been on for 10+ years. My sex drive is back, more vivid, colorful dreams, and just feeling so much more positive thoughts and overall good feeling!"

• Ano...
• Taken for 6 months to 1 year
• April 25, 2025

"I have taken this drug for almost a year now, so I think I know what I am talking about. Started at 5 mg and gradually increased the dosage to 20 mg. Side effects for me have been some fatigue issues, headaches, and nausea, but in general bearable. But as for the antidepressant effect, I don't find it very good, I have actually almost deteriorated in my mood and functioning. It is not nearly as good as citalopram or Prozac, and I will talk to my doctor about getting off of it and restarting any of those."

• tod...
• May 4, 2017

Vortioxetine "This medication was a life changer for me. After struggling with debilitating depression and anxiety and trying several SSRIs, my pdoc did a gene test which uncovered that my body doesn't tolerate SSRIs, so he put me on Trintellix, which is an atypical antidepressant. I finally started feeling the light at the end of the tunnel. I started with 10 mg, upped to 20 mg. I am so grateful for my doctor for thinking outside the box and getting me on the road to recovery. The first few weeks, I did experience severe GERD and even took a PPI for it. But after a few weeks, it thankfully subsided. I started to see improvement after 8 weeks."

• Sav...
• January 7, 2017

Vortioxetine "My husband had been on every drug and drug combo available-nothing worked for his anger, depression, and crippling anxiety. This has been a GODSEND! After 24 years of marriage, I finally feel like I found the loving, kind man I fell in love with. No side effects at all, much more stable moods, and soundly sleeping at night. He also takes Seroquel at bedtime."

• pro...
• Taken for 1 to 6 months
• November 18, 2014

Vortioxetine "I've been on Brintellix for just over 2 months, and it's helped my depression tremendously. I've been on several SSRIs, and this is far and away the best one I've tried. It kicked in a little faster, and the lack of side effects is remarkable. I was irritable when I increased my dose from 5 mg to 10 mg, but it subsided after a month, and I took Klonopin as needed to help. I also noticed some mild scalp tingling, which another person mentioned. No sexual side effects, no weight gain, no TMJ, no night sweats! I'd recommend titrating up SLOWLY if you have anxiety/irritability (cut those annoying egg-shaped pills in half) and taking it with a meal to prevent nausea."

• Ano...
• Taken for less than 1 month
• May 22, 2025

"This is my 17th medication, including SSRIs, SNRIs, antipsychotics, etc. over the last 15 years. Nothing ever worked even a tiny bit on the highest doses for my anxiety and depression. I am on 10 mg and it's only my 9th day on it, and I seriously cannot believe the transformation or that it could be possible to feel more than okay, especially after seeing the low score here. You reading this, that has tried dozens of meds and lost hope, this one might save you as well. Hope it continues this way, I have got my life back! It is not even off-label for anxiety/GAD, etc., but it really worked for me. 8/10 due to some side effects like little nausea and harder to fall asleep. This is a 10/10 if the side effects are gone later on."

• Doi...
• Taken for 1 to 6 months
• December 22, 2017

Vortioxetine "After having been on sertraline for years for MDD at increasingly higher doses and hence pesky side effects, I'd had enough, felt like I was crawling out of my skin with anxiety, which it was supposed to treat. Plus, I weighed more than I wanted to in spite of exercise and diet. Doc prescribed Trintellix, and holy cow, I will never take sertraline again. I have had no side effects, well, dry skin, but that I can manage. No brainy-type side effects, I don't feel sedated at all, but I do feel calm and no depression. No longer craving carbs. I only wish I'd known about this medicine sooner. I feel like myself! The pharmaceutical company has a 'loyalty program' for helping with the cost, do check it out."

• Aut...
• Taken for 1 to 2 years
• April 5, 2019

Vortioxetine "I’ve read many of these posts. I too had nausea (would throw up within 15 minutes of taking the Trintellix pill, every single day). My doctor told me to take an anti-nausea med like Zofran (or generic) 30 minutes before I take this pill. It worked. No nausea at all if you follow that rule. Please try that if that’s your only hold-up. I’ve been on it about 2 years. I STILL have to take a Zofran 30 minutes before Trintellix, or I will puke. Also, take it around bedtime."

• Sai...
• Taken for 2 to 5 years
• June 12, 2017

Vortioxetine "30 years of battling depression - many medications over those years with either undesirable side effects (weight gain, 'flat-lining,' anxiety provoking), or meds that worked well only to lose efficacy over time. Trintellix is a blessing - I have used it since the 1st month it became available - highly compatible and effective, no side effects, and if anything, my mind seems a bit sharper. Only drawback - my private insurance treats it as a category III, so it is very, very expensive - even with the coupons, I still pay $258/month - but I won't go back to anything else."

• Ano...
• Taken for 1 to 2 years
• October 4, 2018

Vortioxetine "I have severe MDD and PTSD. When I started Trintellix over a year ago, it was very helpful. However, the effects seem to have worn off a bit. That said, I haven’t noticed any negative side effects whatsoever and actually lost weight while on it, and it did work in the beginning. So I would recommend this drug, especially since it worked for me more than any other antidepressant and hasn’t come with any of the negative side effects."

• Bea...
• Taken for 1 to 6 months
• June 12, 2023

Vortioxetine "Trintellix was excellent at reducing my anxiety. At my most anxious times, it would make me feel like it was just another day. My life is super stressful caring for a dying parent, so any relief from feeling constantly anxiety-ridden was so helpful. HOWEVER, the side effects outweigh the benefits. I would often feel nauseated and throw up. I got involuntary muscle spasms that have still not gone away 2 months later. I could still enjoy intercourse, but I was never aroused. It also made me feel like I had an eating disorder. When I was hungry, I was HUNGRY. I would overeat and consume WAY too much - especially sugar. I gained like 15-20 lbs on Trintellix and had to be put on blood pressure medication for the first time in my life. Ultimately, my doctor decided it wasn't in my best interest to continue using it. When I got off of Trintellix, I felt like a cloud had been lifted. I felt happier and could feel emotions again. I've also lost some of the weight I put on from using it."

• tom...
• October 20, 2016

Vortioxetine "I started taking it 8 days ago. I started to feel a little better each day. I did have nausea the first day. I noticed that when I get excited or run around too fast working, I get a little nausea, but not too bad and it passes when I calm myself. I'm very happy with the way it's working. Oh, and taking 10 mg."

• Jad...
• November 1, 2019

Vortioxetine "After being on a variety of antidepressants for over 20 years, this is the best that I have taken. I feel so much better. I have had migraines, and I don’t get headaches anymore. The only drawback is I’m hungry all of the time, so I’m going to have to watch what I eat. If you’ve been on other meds and they have run their course, I hope that you try this when it works for you as well that is working for me. Currently on 10 mg a day."

• Ano...
• Taken for 1 to 6 months
• June 17, 2025

Vortioxetine "I was looking for treatment for long-term depression/sadness/burnout, and here is what Trintellix (Brintellix as it is called here in Europe) did for me: - stopped extreme sadness and crying almost immediately, although I was told that it took longer for the medication to work - made me feel stronger (mentally) and more motivated to do things - decreased irritability - increased libido (no sexual side effects, for me) Here is what Trintellix did not do for me: - take away fatigue - take away mental chatter/invasive thoughts (although it did reduce the sadness of my thoughts) I was very resistant to take an SSRI, but once I did (10mg) and got over my initial fear, I was actually happy to take it. I was lucky to have no side effects, both when starting and tapering off. I have been off the medication for two weeks now, but am considering starting again as I have felt some of the symptoms coming. For me, being on Trintellix was a very positive experience."