Vortioxetine for Major Depressive Disorder User Reviews (Page 4)

• hoffg...
• Taken for less than 1 month
• April 4, 2024

"I have never written a review on here before but as Vortioxetine is a medication I have never tried before, and there is little information online, I wanted to add my experience. I am 63, an intelligent and insightful woman who also has in-depth training in psychology. I have familial depressive disorder. For most of my life, on and off. Because I have experienced awful side effects with SSRIs and a couple of SNRIs, my GP suggested I try Vortioxetine. To be honest, I had never heard of it before. My GP described that it is usually offered to people who haven't had much luck on SSRIs as this one works differently. I was hopeful. As I am sensitive to all medications, my GP said to start low... on 5mg. I took this for a month. Absolutely no side effects. It felt like a cleaner medication than SSRIs. But I have to say that while I noticed that I was able to get out of bed in the morning without ruminating or worrying, I have not felt more of an improvement in my mood."

• Anonymous
• Taken for 1 to 2 years
• July 2, 2016

Trintellix (vortioxetine) "I've been taking this for over a year. Fortunately, I never experienced any of the side effects described by many people here. I always have such high hopes when trying something new for MDD. This medication did not deliver the hoped-for miracle of no more depression, but I must say, my mood has improved to a degree. I am able to get 'up' for certain activities now, where this was very difficult while on other medications. This has lightened my mood better than Viibryd or Cymbalta."

• Char
• Taken for less than 1 month
• August 28, 2019

Trintellix (vortioxetine) "Will probably update later when I’ve been on longer, but so far it’s been very helpful. I’ve been on several antidepressants over the last decade (only one has ever worked and had to be discontinued due to worsening side effects) and had no problem getting approval from insurance. I started on 5 mg for a week and had slight nausea on days 2-5 a couple of hours after taking with food that lasted about 20-30 minutes. I’ve been on 10 mg for a week and no nausea. It’s actually improved my IBS. Appetite has been the same. My depression symptoms mainly manifest as fatigue/exhaustion, brain fog, forgetfulness, lack of motivation. I feel great, I’m motivated, I’ve been working out, getting more done at work and at home, sleeping less (now I’m sleeping more like 8 hours instead of 10-12). My out of pocket is $100 for a 30 day supply of 10 mg, I’m looking in to bringing the cost down, but if I can’t it’ll be well worth it for how good I feel."

• LANIE
• Taken for 1 to 6 months
• September 23, 2020

Trintellix (vortioxetine) "I had severe nausea. I would take Trintellix every morning and within one hour after taking this medication I was vomiting severely. It went on for a couple of months and I had to be changed back to Lexapro! I was so disappointed, because it made feel better. Even after I would vomit, I was okay so in order to keep taking the medication I had to be put and take zofran every day. I didn't feel it was worth it so I switched back to Lexapro. Has Anyone else had these side affects. What should I do? Please help me out! Thanks"

• happy...
• October 31, 2014

Trintellix (vortioxetine) "I have been depressed for 12 years. Throughout my life, I've contemplated suicide. I had paranoid thoughts and had very little self-esteem. I have been on and off multiple antidepressants and couldn't find one that made me feel like myself again. Finally, when I started to experience severe mood swings and found myself becoming angry for no reason to the people I loved, I decided I should try to get help once again. My doctor started me on Trintellix, and it has helped me so much. Fortunately, I don't experience any side effects. My mood is elevated, I'm gaining my confidence back, I'm more motivated, and most importantly, I feel like myself again. I'm taking 10mg currently and find no need to go to a higher dose. The only downfall is the cost."

• Payro...
• Taken for less than 1 month
• October 12, 2018

Trintellix (vortioxetine) "I have been on Zoloft for about 5 years with no problems. But recently I started having panic attacks again, was always tired no matter how much I slept, couldn't enjoy life and was having suicidal thoughts again so my GP switched me to Trintellix. I'm about 2 weeks in and so far so good! Almost immediately the suicidal thoughts stopped and I actually have energy again. I am still struggling with not wanting to go out and do things, but am pushing through. I am very happy with the results so far. Side effects are mild nausea for a couple hours after dosing and trouble sleeping. My head is feeling a little "swimmy" at times too, but I think that may be from stopping Zoloft. "

• Babyc...
• Taken for less than 1 month
• December 9, 2019

Trintellix (vortioxetine) "I’ve been on the 5 mg for about a week now. I switched over from Zoloft because after many years it stopped working. So far I have felt great. I haven’t had any nausea or adverse effects. I up my dose to 10 mg in a day or so, and I’ll update if I notice any changes, good or bad. So far it’s been great though. I would say that the only effect I’ve noticed is my clothes are fitting differently. I haven’t weighed but I think I’ve lost some weight! I’m pretty optimistic."

• Anonymous
• Taken for 6 months to 1 year
• August 3, 2015

Trintellix (vortioxetine) "I am a 42-year-old mother. I have been depressed all of my life. Never been happy more than a few weeks at a time. I have tried a few different meds but no real change. I would also self-medicate with alcohol. At least once a week, I would get too drunk, I would black out. As you probably figured, that caused a lot of problems in itself. I started taking Trintellix 6 months ago, and I have NEVER been so happy in my entire life! I love it! It really changed my life for the better. No more drinking at all. I'm so happy, and my family has also seen the change and are more happy."

• Tired...
• May 6, 2017

Trintellix (vortioxetine) "I have been battling major depression and anxiey for years and was at the point of saying this illness is meant to be my fatality. After several tries on different antidepressants. Trintellix has given me a new outlook on life. If you are at the point of tiresome trial and error do not give up until you try Trintellix. The benefits out way the side effects."

• V77xx
• Taken for less than 1 month
• March 27, 2024

"I took it only for 12 days at 5mg. I was hoping, after trying many types of antidepressants during the last 15 years, that this one would have helped. It took away the brain fog. It activated me and I had more motivation and focus during the day, but gave me horrible insomnia which affected my wellbeing during the day. This is not good because I was able to sleep before this medication. After struggling with insomnia for 2 years, I was again able to sleep but this medication brought me back to square one. So I was told it is better to discontinue it and try a new one. I am now tapering it off."

• Steph...
• Taken for 1 to 6 months
• December 7, 2014

Trintellix (vortioxetine) "I had no ill side effects with this medication. But, my doctor gave me samples, and when the samples were gone, my insurance wouldn't pay for the medication. I came off of it even though it worked because of the cost."

• Helpful...
• Taken for 6 months to 1 year
• February 1, 2024

"Helpful but gave more of a euphoria in the first 6 weeks. I do miss it, but it still keeps my suicidal thoughts totally away, and I feel more leveled out against boredom. The only thing it lacks is the removal of anhedonia."

• Ottawa...
• February 2, 2016

Trintellix (vortioxetine) "Tried many drugs over the past 20 years. This is the best yet. No strange feelings in the head, no twitching muscles or fog. Some stomach discomfort which was solved by splitting the 10-milligram tablet in two and taking morning and afternoon. The quality of my life has improved beautifully, and I am so grateful for it."

• rowan
• August 31, 2018

Trintellix (vortioxetine) "I had tried cipralex for a while when I was younger and it helped with my depression but the side effects were unpleasant and unhelpful. I had sexual dysfunction, blunted emotions, and a terrible crash after one beer resulting in weeks of anxiety. I was off and barely scraping by without help for years when I finally saw a new doctor who listened to my story and recommended trintellix. On the first day I noticed my mood improve. Over the weeks the residual anxiety vanished. I felt excited to wake up with the sun for the first time since childhood. The nausea was difficult to cope with, but if I take it before bed when already sleepy I am asleep before the nausea starts. It helped my concentration a little and we added concerta to the mix. I still cry but it's when I have a reason to now. Little things people take for granted, like vacuuming and doing laundry, are possible. It drained my savings but it helped me feel ready to try again. I'm finally employed and getting somewhere again."

• Jenn...
• Taken for less than 1 month
• May 6, 2017

Trintellix (vortioxetine) "I have dealt with chronic depression most of my life & I am 65 years young. I have been on so many pharmaceuticals over the years; starting at age of 23 (Valium, Zoloft, Wellbutrin, Paxil, Buspar, Effexor, Pristiq, etc) and Cymbalta for 15 years. Current dose is 90 mg daily (1-60 mg & 1-30 mg). I went to see a Psychiatrist at my Family Practice Docs suggestion we felt I needed a change. I have also had Fibromyalgia for 25 years plus & collected disability. Cymbalta has had the most longevity with me because it also managed my Fibro. 1 month ago I started on 5 mg of Trintellix. No side effects for 2 weeks. Then she bumped up to 10 mg & no side effects except exhausted. Removed 30 mg of Cymbalta & its’ been 2 weeks & I feel great. I feel blessed – no side effects except being tired."

• DebraD
• Taken for less than 1 month
• September 29, 2019

Trintellix (vortioxetine) "Only on the Trintellix 5mg for week #1. I feel better already. I was a failed of 2 different other antidepressants. I WAS losing my temper at work, wanting to get even with those who made me mad. I recognized that I needed a change as that was not me. My Dr. told me to take the medication with peanut butter, or at least with a meal so I wouldn’t be sick as it is a side effect. I know I’m only in the first week, but I am getting back to me already, as noted in better hygiene on my days off, actually getting out of bed. I have started cleaning up my house again. Yes it has given me diarrhea some, but I have no gallbladder in which also gave me diarrhea. Simple fix with incorporating yogurt into my daily diet. So far I am very pleased with Trintellix. My insurance company thankfully will cover the medication because of the past failure of the previous 2 I have tried."

• Gio
• December 16, 2014

Trintellix (vortioxetine) "I was admitted into a clinic and was monitored for 3 weeks. After the 2nd day, I started feeling a change and after 4 weeks, it's still good. Energy levels are up, thinking positively and coping with society and life again. Only downfall for me is trouble sleeping. Two thumbs up!"

• Tammy...
• Taken for 1 to 6 months
• November 29, 2014

Trintellix (vortioxetine) "I've had the side effects of nausea, diarrhea, and low sex drive. Even so, it has helped improve my mood and reduced my anxiety. The side effects have decreased in the past few weeks, but at first, they were bothersome. Largest complaint is the copay! Our cost is $122 after insurance! Outrageous. I probably won't be able to afford it for long. Sad because I finally found something that was working."

• GTL
• Taken for 1 to 6 months
• April 9, 2020

Trintellix (vortioxetine) "I’ve tried citalopram, Effexor, Wellbutrin SR and XL and Trintellix for anxiety issues, but all seemed to cause more anxiety and added depression, than I had before I started taking them. Every time I stop taking them I feel significantly better. Other negative side effects for trintellix specifically included nausea (I had to stop eating specific foods and because I was taking the medication with water I felt sick every time I drank it throughout the day), lower sexual appetite (significantly, was affecting my relationship), and lack of focus (I’m honestly lucky that I didn’t lose my job the week before I stopped taking them). I know I’ve had anxiety my whole life but the more I observe my issues, I’m fairly certain that the majority of my anxiety is caused by ADD."

• apath...
• March 9, 2015

Trintellix (vortioxetine) "1 month in and I'm tolerating this medicine really well. I have Bipolar Disorder, but I'm taking it for depression and anxiety. I'm currently taking 10mg. I have occasional diarrhea and nightmares (may be the Lamotrigine), but that's it. So far I'm feeling more optimistic, I'm making plans for the future, I want to go out and socialize more often, and feel much more calm. I've tried more antidepressants than I can count and have been taking them since 1991. This is by far the best so far."

• Coach
• Taken for 2 to 5 years
• August 14, 2018

Trintellix (vortioxetine) "For years I’ve experienced various forms of depression including post partum (PMDD), and MDD. My treatment regimen has included SSRI, SNRI and Wellbutrin. To my dismay none of these agents seemed work for me and as a result, my depression relapsed and my episodes were greater, even to the point of suicidal thoughts. Often times I would have talks with my psychiatrist that while being on the prescribed medicine, “ I don’t know how I’m supposed to feel.” Come to find out later these feelings were a result of the medication not helping me. After a few years of complete misery and helplessness, Brintellix came along. My world changed. Within the first week I was feeling complete. I was sleeping well, had more energy and I also found interest in things again. The biggest improvement was my focus and concentration. More than 3 years later, I’m still in this drug and experienced absolutely no side effects."

• Leah
• Taken for 1 to 6 months
• February 12, 2020

Trintellix (vortioxetine) "After 2+ months being on Trintellix (10 mg), I am weaning myself off as quickly as possible. The side effects have been almost unbearable for me and my family. Daily feelings of nausea and frequent vomiting were bad enough, but the significant irritability and difficulty getting a deep breath were increasing and were the final straw for me!! I ended up in the ER 3 weeks ago because I was struggling to get a deep breath. After thorough testing, it was determined nothing was wrong. Deep search on Trintellix side effects made it clear the problem was this medication. I am now taking every other day until next week when I meet with my doctor. I hope no one else responds to this drug as badly as me! Take care! I definitely received no improvement in my depression and only major side effects that I can't live with."

• Jeffrie...
• July 9, 2015

Trintellix (vortioxetine) "It is amazing. I have been on antidepressants on and off since I was 16 years old. I am now 19 and my life has completely changed around. My sleep is better, my appetite normal, my mood heightened, anxiety is away, and I don't feel as if there's something weighing down my heart. Please, if you are depressed right now, I highly recommend this medication. My dad has been using it too and he is genuinely happier with his life; I can see it in his eyes."

• Xaney
• October 16, 2016

Trintellix (vortioxetine) "My Doctor gave me Trintellex recently for MDD And Anxiery Disorder. I was on viibyrd on and off for 3 yrs and it was not working for me anymore. I started Trintellex at 5mg for 7 days and now on 10 mgs, Day 5. I'm not crying anymore, my anxiety level is almost nothing and I feel happier. The only side effects I got was nauseated after taking the medicine for about an hour and itchy. I had to take a benedryl. These pass after about two weeks. I do not feel clouded like most other ssri make you feel or tired. I just feel normal! I think this is a great Medication."

• JC28
• January 21, 2019

Trintellix (vortioxetine) "I’ve been on Trintellix 10mg daily for about four years; this last Spring of ‘18, I upped to 20mg. I felt my depression was getting bad again. I did see improvements with the higher dosage. I also take Propranolol daily for anxiety, which has helped significantly. In the last three months, my depression and anxiety symptoms have returned almost full force. I just started reading about side effects with both meds, and am putting some important pieces together. Within six months of beginning Trintellix, I began experiencing constipation, stomach pains, and mild joint pain. The symptoms were so bad, my Dr had my gall bladder removed. Nothing has changed. Now, I can’t help but connect the symptoms to Trintellix- can’t be 100% sure, though. Trintellix served me well for a period of time, but as usual, I’ve developed a resistance and need to search out another option. I hope this is helpful to those looking for more info on possible use of this Rx."