Skip to main content

Sunosi and Depression: What Users Say

Depression: mentioned by 3 users (3.8%)

Based on user experiences from 80 Sunosi reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

irritability 8.8%
high blood pressure 7.5%
increased heart rate 7.5%
tiredness 7.5%
insomnia 6.3%
anxiety 5.0%
fatigue 5.0%
headaches 5.0%
nausea 5.0%
depression 3.8%

Reviews for Sunosi

  • Tir...
  • Taken for 1 to 6 months
  • October 29, 2019

For Narcolepsy "So I’ve been taking the 150 mg for about five months now. At first, it seemed like it was helping me, and I didn’t get the crash with the Adderall. At this point, I’m not sure if I still feel that way. I still get excessively tired, and I am extremely moody. I don’t have any motivation at all, and I feel as though my chest is tightened around hour two, and I’m almost in a daze/fog. The depression associated with the narcolepsy seems to be getting worse. I definitely think I need to change it. I was never on Provigil/Nuvigil since I was diagnosed right when this drug came out."

5 / 10
Was this helpful?YesNo
48 Report
  • Sle...
  • June 6, 2021

For Narcolepsy "I have narcolepsy with cataplexy. I have been on Provigil and Ritalin for several years, always sleeping, however, I could function and be motivated. Started taking Provigil and Sunosi in November 2019. At first, I thought I had found the drug, after about three months, the drops came, no motivation. The best way to describe me is my eyes are open, the rest of me is asleep. No focus, all over the place."

3 / 10
Was this helpful?YesNo
14 Report
  • Anonymous
  • Taken for 1 to 2 years
  • February 26, 2023

"Initially, it worked okay. The brain fog was gone, I had energy and was not tired all day. Now it is not consistent at all. Sometimes I take it, and it does nothing. One thing I have found is it affects my mood pretty badly. I will get really agitated and angry and then end up depressed. Don't think it's worth taking if it doesn't always work and affects my mood to this extent. Wonder if I'm the only one having depressive episodes with it."

2 / 10
Was this helpful?YesNo
2 Report

Frequently asked questions

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.