Semaglutide for Weight Loss (Obesity/Overweight) User Reviews
Brand names: Ozempic, Wegovy, Rybelsus
Semaglutide has an average rating of 7.3 out of 10 from a total of 613 reviews for the treatment of Weight Loss (Obesity/Overweight). 63% of reviewers reported a positive experience, while 19% reported a negative experience.
Reviews for Semaglutide
- Helene
- June 19, 2023
Ozempic (semaglutide) "After 1 year of taking this, I began suffering from severe abdominal pain. A couple of months later, while watching TV, I heard an Ozempic commercial that included warnings about gallbladder problems and pancreatitis. I immediately stopped using it and went to my doctor. I had to have my gallbladder removed. I gained the 50 pounds back that I had lost the previous year. Although it was effective, it was not worth the side effects."
- JAO
- Taken for 1 to 6 months
- June 14, 2023
Wegovy (semaglutide) "I had been on this drug for 4 months. Typical escalation dose until month 4 I stayed on the 1mg. The side effects were rough since increasing to 1mg. So much nausea, worsened reflux, constipation, bloating, burping, and indigestion. I vomited once but there were a few times I almost did. In the last few weeks, I noticed hair loss. Noticed skin tags that I have never had...like 3 grow since the med. Weird. Oh, and I had serious issues with certain smells. I had to change out the hand soaps in my house 5 times. If I smell rubbing alcohol I am instantly nauseous. Just looking at the wegovy box before injecting would make me dizzy and nauseous. So weird. Difficult to eat healthy on this med due to side effects and only able to tolerate simple carbs, low-fat diet. Also hard to work out when feeling so nauseous...so didn't think it was contributing to my health. Has not really contributed to weight loss and appetite is almost the same as before med."
Frequently asked questions
- Tirzepatide vs semaglutide: How do they compare?
- How does semaglutide work for weight loss?
- Why am I not losing weight on Ozempic?
- How much does semaglutide cost?
- WmB
- Taken for less than 1 month
- June 13, 2023
Wegovy (semaglutide) "Wegovy hasn't resulted in any weight loss. At times I'm nauseous, full, and constipated regularly. Also, the injection device failed to work, no clicks or moving yellow bar. The product failed to go in and leaked all over thereby causing me to get no shot/dosage. "
- XXO
- Taken for less than 1 month
- June 11, 2023
Ozempic (semaglutide) "I experienced vomiting within one hour, swelling of the throat, and difficulty swallowing which has not stopped since the first and last dose on Sept 6th, 2023. Now hypersensitive to all regular daily medications and am taking Benadryl several times per day."
Are you taking this medicine?
- Comba...
- Taken for less than 1 month
- June 10, 2023
"Started on May 23 at a 0.125 mg dose and spent the entire Memorial Day weekend sicker than I've ever been. I didn't put two and two together until after I took my second dose on May 30. Two nights later, I woke up with my body uncontrollably shaking, and I had my hand on my phone, ready to call 911. I didn't take my third dose on June 6 and don't plan to ever again, despite my doctor telling me to take a two-week break and retry it. He says the side effects are typically more tolerable after a two-week break, but I'm not willing to chance it. Since day one, my symptoms have been extreme fatigue, making it impossible for me to function in daily life. I can't do my job and I'm hardly able to be there for my kids without pushing myself as if my life depended on it. I've been missing out on everything for over three weeks because all I can do is go from bed to couch. Additionally, I've experienced severe confusion, heaviness in my head, nausea, and vomiting, and I've lost 16 pounds."
- Bonnie
- Taken for less than 1 month
- June 10, 2023
Wegovy (semaglutide) "Honestly, I have never been so sick in my life. 1st and only dose of wegovy made me so incredibly sick. I have been in the hospital twice for excessive dry heaving. There is no stopping the symptoms. I had short term relief with IV sedatives and anti nausea medications. Still a week later now at home throwing green bile. I will never recommend to anyone."
More FAQ
- How does Ozempic affect blood pressure?
- How does taking Ozempic affect your face?
- What foods should I eat or avoid when taking Rybelsus?
- Why does Ozempic cause a dry mouth or taste changes?
- Never...
- Taken for 1 to 6 months
- June 10, 2023
Wegovy (semaglutide) "Let me first say that digestively, I have never been more miserable in my life than I was on this "medication." Wegovy gave me abdominal cramps so bad I had to go to the ER. I was very dehydrated and in so much pain. Luckily my CT was normal, but my WBC was elevated. Maybe this is some other side effect that will start being reported more often now that half the population seems to be taking it. I started at 0.25 mg and did that weekly for 4 weeks. During that time, I was ok but constantly felt somewhat bloated and would burp way more than what would be considered normal. I am glad some people had success with this but for me, my life was better before this medication. I'll take being "overweight" and feeling great to this any day. I just hope there is no permanent damage. Thanks for the misery, Wegovy. Never again. Big pharma can take their bogus, fabricated BMI and stick it. They want people to be miserable and addicted to whatever drug they cook up for their investors."
- Mary
- Taken for 1 to 6 months
- June 10, 2023
Ozempic (semaglutide) "I took it for two months and I was very happy to lose 20 pounds so fast. After I stopped it I regained everything back and even more. The sad news is I got gallbladder problems from ozempic and my gallbladder has to be removed. Not worth it."
- Miche...
- Taken for 1 to 6 months
- June 7, 2023
Ozempic (semaglutide) "I had horrible experience. Abdominal pain going to back. Constant nausea. Depression - very strange feeling, almost like out of body experience. For first time found myself HATING body. Extreme tiredness. Difficulty focusing. Gained 9 pounds in 3 weeks. Constant headaches."
- Lisa...
- Taken for 1 to 6 months
- June 6, 2023
Ozempic (semaglutide) "I'm now on my 2nd week of 1mg Ozempic and so far I've seen zero side effects and nothing positive, no weight loss."
- Kim
- Taken for 1 to 6 months
- June 5, 2023
Wegovy (semaglutide) "I wish I had great news to share but I don't have any, yet. I'm in my 4th month of using Wegovy. I started my 1st month at the lowest dose and each month have bumped it up to the next one. I take my 3rd injection of the 1.7 mg dose tomorrow and unfortunately, I have not lost any weight yet. In fact, I think I may have gained about 7 lbs. I'm not entirely blaming the drug. It says right on the informational paper it is more effective with a healthy diet and exercise, which I have not been consistent with. The one thing that I have noticed, is it has helped me feel less hungry. I'm hoping once I get to full dosage and am consistent with eating healthy, I will then see weight loss results."
- Sks
- Taken for less than 1 month
- May 25, 2023
Wegovy (semaglutide) "I never leave reviews and rarely have side effects from medication. However, after one injection on the lowest dose, I am so beyond sick. Two days after my injection, I got a migraine followed by extreme vomiting for 4 days, chills, nausea, and a trip to the ER. This medication made me so unbelievably sick, it is like I've been poisoned. I have missed 4 days of work and am so weak. Living on Pedialyte and numerous nausea medications. Please be so careful. I was so hopeful and had no idea this would happen to me."
- Dkedz...
- Taken for 1 to 6 months
- May 19, 2023
Ozempic (semaglutide) "I had high hopes for this drug and stuck with it as long as I could but it caused severe constipation, stomach cramping and fatigue. I started out with .25 mg for 4 weeks then .50 for 2 weeks. I didn’t lose weight so my doctor increased the dose to 1 mg but I just couldn’t tolerate the side effects at the lower doses so I didn’t even try the 1 mg."
- 1887 ...
- Taken for 1 to 6 months
- May 17, 2023
Wegovy (semaglutide) "Started Wegovy 3 months ago using the gradual phase-up method. From .25 mg dose for 4 weeks to .50 mg dose for 4 weeks then 1.0 mg dose for 4 weeks. During the initial phase, I experienced mild nausea and some stomach irritation. With each increase the symptoms got worse until finally at the full 1.0 mg dose I was so sick I thought I had stomach flu for 2 weeks continuously. The belching was horrible. The nausea caused uncontrollable vomiting and I had frequent diarrhea. After 3 months I lost 12 pounds and felt horrible every day. I've now reduced the dose to .5 mg but still suffer from nausea and stomach upset. I might cut back again but I'm thinking I will quit. The way I feel all the time is horrible!! I'm thinking I lost weight because of all the vomiting. Not recommended."
- susie
- Taken for 1 to 6 months
- May 17, 2023
"I have been using this for 6 weeks now and have gained weight! It is very expensive and doesn't work, I'm not happy."
- Peggy
- Taken for 1 to 6 months
- May 16, 2023
Wegovy (semaglutide) "Have been using this Wegovy for about 3 months with absolutely NO results. I do get really bad heartburn after my injections. I'm on the highest dose that you can be on and it hasn't helped with suppressing my appetite at all. Worthless drug. Don't waste your money. I gave it my all and I'm done with this stuff."
- Ozempic
- Taken for less than 1 month
- May 14, 2023
Ozempic (semaglutide) "With just one 0.25 mg dose I became very ill. Relentless nausea, vomiting, and explosive diarrhea as well as unbearable stomach cramps. Needed to go to the ER for fluids and to check for pancreatitis. It’s now been 9 days since my first dose and I still have relentless diarrhea, nausea, and disabling fatigue. I don’t want to eat. I didn’t want to take it in the first place but was ambushed by my kidney doctor. She told me that using Ozempic was a no-brainer and that I would just have a bit of nausea. If you have any gastrointestinal symptoms when taking any medicine, I would think three times about it before using it. I have read it can take up to a month for it to be flushed out of your body but I am hoping and praying that these horrible side effects stop real soon."
- Anonymous
- Taken for less than 1 month
- May 9, 2023
"Received the shot yesterday at 3 pm and by 6 pm I had severe stomach cramps and diarrhea. Around 1am I started vomiting uncontrollably. I’ve been in bed all day today and had to miss work. All this within 24 hours. I understood there would be side effects - but this is horrible! Would not recommend and will not be continuing this medication."
- Carma...
- Taken for 1 to 6 months
- May 7, 2023
Ozempic (semaglutide) "I am really disappointed with this drug. It has done absolutely NOTHING for me for weight loss. Didn't stop cravings or anything. I know that I have tried hard to watch what I eat and do moderate exercise but have retained no results. I do get a case of terrible heartburn after each injection. Don't waste your money on this stuff."
- Kate
- Taken for less than 1 month
- May 4, 2023
Wegovy (semaglutide) "I have been on it a week. Have not lost even a 1/2 a pound. Feeling more hungry each day. Appetite not suppressed at all. Very discouraging!"
- Anonymous
- Taken for less than 1 month
- May 1, 2023
Wegovy (semaglutide) "I started Wegovy 5 days ago, I been having hives everyday. I been taking Allegra around the clock. The minute the antihistamine wears off the hives comes back and its worst at night. It is a wrap for me! I am praying to God for relief and that this medication get out of my system."
- abcc-1
- Taken for 1 to 6 months
- April 29, 2023
Ozempic (semaglutide) "I have been taking this shot once a week in the doctor's office. In my first 3 weeks, I was losing 1 to 3 lbs per week. To date, I am not losing anything and most weeks I have gained the weight back. It's been 9 weeks in total and I have lost 6 lbs. The syringe is not prepared in my view so I am not sure if I am getting the Ozempic or the proper dose. I am really thinking about stopping the program."
- HELENA
- Taken for 1 to 6 months
- April 28, 2023
Ozempic (semaglutide) "Don't know what all the hype is about because it has done NOTHING for me."
- Debbie...
- Taken for 1 to 6 months
- April 25, 2023
Ozempic (semaglutide) "I started using Ozempic in Feb 2023. During the first three weeks, I experienced a lot of vomiting and diarrhea, so I stopped using it. I waited for three weeks and then tried again. However, after two injections, I became severely dehydrated and ended up in the ICU at the Heart Center. I had collapsed at a baby shower due to dehydration and was experiencing blood loss in my stools, anemia, and electrolyte imbalances. I could have died, but thankfully, I am still here to share my story. Ozempic may work for some, but it is definitely not for me."
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
Learn more about Weight Loss
- Can You Mix Weight Loss Drugs and Alcohol?
- FDA-Approved Weight Loss Drugs: Can They Help You?
- How to Calculate Your Body Mass Index (BMI)
- Side Effects of Weight Loss Drugs
- Surgery for Weight Loss: What Are Your Options?
- U.S. Childhood Obesity Epidemic: Treatment and Prevention
- Weight Loss Drugs: What Are Your Options?
- Which Drugs Cause Weight Gain?
Care guides
More about semaglutide
- Check interactions
- Compare alternatives
- Reviews (2,131)
- Latest FDA alerts (2)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: Incretin Mimetics (GLP-1 Agonists)
- Breastfeeding
- En español
"Started with .5 mg twice a week as a once-a-day eater with portion control issues. Looking to lose about 20 pounds. On day 1 I had nausea, by day 3 the nausea worsened and I had bad diarrhea. After the second injection, I experienced heartburn, acid reflux, gas, and diarrhea. The worst side effects by far though are the stomach being bloated and cramping. It's like it has food in it that is not being digested and sits there with more and more stomach acid being produced. This is my second missed day of work because of stomach pain and nausea. I am going to start exercising and focus on eating less and avoiding cravings for me. Semaglutide is going in the trashcan. My digestive tract has never been so confused. I am a 37-year-old male 6"3 200lbs."