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Semaglutide for Weight Loss (Obesity/Overweight) User Reviews (Page 3)

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 7.3 out of 10 from a total of 613 reviews for the treatment of Weight Loss (Obesity/Overweight). 63% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Semaglutide

  • Bobbi...
  • Taken for less than 1 month
  • July 23, 2022

Wegovy (semaglutide) "Horrible experience after taking just first dose. I’m going on my third week of being out of work. I have never been this sick. Violently vomiting one hour after my first and only dose. Heartburn , no energy, brain fog, couldn’t even speak coherently for first 48 hours after taking. This stuff is like poison. Do not take it."

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  • Gabe
  • Taken for 1 to 6 months
  • July 9, 2022

Wegovy (semaglutide) "Horrible, I had smelly sulfur burps and nausea at 1.7 mg. After the 2.4 mg limit I became violently ill for two days. It was projectile from both ends. Very embarrassing. After that just constant diarrhea for days. Throw it in the garbage."

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  • LADw
  • Taken for 1 to 6 months
  • July 4, 2022

Wegovy (semaglutide) "I took Wegovy for a few months and did, in fact, lose some weight. The side effects are terrible, as so many others have noted here. One thing that they don’t tell you is that the drug slows down the stomach's ability to empty. This is why people feel full and experience reflux, nausea, etc. In my case, the drug not only slowed down my stomach's ability to empty, it permanently paralyzed my stomach muscles, a condition called gastroparesis. The only remedy was to have a neurotransmitter implanted in my stomach, which forces the muscles to move. Do NOT take or first this medication. You could end up like me with a lifetime medical issue. No weight loss is worth that."

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Frequently asked questions

  • OR RN
  • Taken for 1 to 6 months
  • July 3, 2022

Wegovy (semaglutide) "I lost 75 lbs on Wegovy. It wasn't worth it. People assume I have all this energy now. I feel like a shell of my former self. Run down, no appetite...and just got back from the hospital, since I didn't have a bowel movement for almost 2 weeks once I was at the 2.4 dose. I can't recommend this drug. You will essentially give up your normal life to lose weight. To me, the benefits don't outweigh the risks."

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  • Patient
  • Taken for less than 1 month
  • June 24, 2022

"This was the worse medication I have ever taken. I was sick literally so sick to my stomach I could not concentrate. I lost 3 days of work and was not given anything by the weight loss center for the extreme nausea. I also had side effects of headaches, my BP rose to a point it has never been, I felt so weak and tired looked like death I had no color in my face. I literally have a cast iron stomach and nothing ever bothers me, this however was pure nightmare. It is not worth taking for loosing a few pounds, please stay away from this drug. I had to literally stay as still as I possibly could so I would not throw up. For whatever reason I even lost my taste and it has been 10 days. I just can't say enough bad things about this medication. I am just a regular mom trying to look my best and thought this would help, however this is one of the biggest mistakes I have ever done and I still regret it. Please think twice before you inject this in your body, I wish I had done more research. Hopefully I can help someone else."

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Are you taking this medicine?

  • Scary
  • Taken for 1 to 6 months
  • June 20, 2022

Wegovy (semaglutide) "Wegovy definitely works if you can tolerate being nauseated all the time; it takes away cravings for everything, I had to force myself to eat. Fast forward 4 weeks on meds I ended up getting the sickest I have ever been in my life! Thought I had the stomach flu for 4 days but it just kept getting worse. Ended up in ER with an inflamed liver, kidneys, severe kidney infection, urinary tract infection and dehydrated. I would do anything to lose weight because I need a knee replacement and DR wants me to lose 30 pounds before he will operate. This scared me, BAD. I still don’t feel 100%. Anyway who doesn’t want to lose weight right? Wellllll After my experience this is just not worth it. BTW I have never had any issues with kidney, liver, etc. it was from this drug."

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  • Sick
  • Taken for less than 1 month
  • June 11, 2022

Wegovy (semaglutide) "Doctor skipped to 1.7 and I’ve been sick going on 4 days now. Severe nausea and vomiting, stomach pain and headache, dehydration."

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More FAQ

  • Elzbe...
  • Taken for 1 to 6 months
  • May 29, 2022

Wegovy (semaglutide) "Started this 2 months ago. Was supposed to start month 3 and now they are out of stock. I have wasted money for nothing and who knows when it will be available. From what I have read won’t be anytime soon.Not impressed…"

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  • Shark
  • Taken for 1 to 6 months
  • April 26, 2022

"Took this for 4 weeks, all I got was a migraine I couldn’t get rid of and nausea. No weight loss complete wast of money."

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  • Marie
  • Taken for 1 to 6 months
  • April 2, 2022

Wegovy (semaglutide) "No weight loss at all in 3 months. I’m at 1.5 dose now. I also have a sluggish thyroid so not sure. Feel an upset stomach, acid reflux and nausea. And very tired after the injection. Have lost about 3 lbs and gain it back by the next day. I eat low carb and usually I’m not hungry. I have no idea why I'm not losing any weight."

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  • Jax
  • Taken for 1 to 6 months
  • March 31, 2022

Wegovy (semaglutide) "I had to stop Wegovy after my 9th week. I have autoimmune and 2 days after I increased to the 1.0 dose, my right side was hurting so much. I went to the doc and had an ultrasound. My gallbladder is inflamed. I now need surgery and also my inflammation C Reactive protein count is normally at .5, it was 12 yesterday. It is supposed to stay under .5. Beware if you have any autoimmune issues because when I went up in dose it made my immune system go crazy. I’m praying this drug leaves my system quickly. Took it 3 months and only lost 2 pounds. Never again"

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  • Mered...
  • Taken for 1 to 6 months
  • February 25, 2022

Wegovy (semaglutide) "I am on 1.0 and am always sick. I have lost 22 pounds since 11/2. I haven’t lost in 3 weeks. I can’t live like this. I am not taking another injection."

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  • Mikk
  • Taken for 1 to 6 months
  • February 22, 2022

Wegovy (semaglutide) "6 weeks have loss nothing. No side effects, no nothing."

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  • tadaaa
  • Taken for less than 1 month
  • January 27, 2022

Wegovy (semaglutide) "Just started my 4th injection (1 month) and nothing. Barely noticeable side effects but disappointed that it is not working considering the cost. I am hoping it starts working with higher dosages (if I can afford it)."

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  • Anonymous
  • Taken for less than 1 month
  • January 22, 2022

Wegovy (semaglutide) "Worst experience of my life. After the second 0.25 dose, I was up all night vomiting and diarrhea. The next day, I had chest pain, shaking, brain fog, stomach pain, more diarrhea, and had to go to the ER. After they gave me Benadryl and morphine, I started to feel better. Still have burping, gas, and acid reflux terribly. WILL NEVER TRY THIS AGAIN! It is not worth it to me! Wish it would hurry up and get out of my system."

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  • find...
  • Taken for 1 to 6 months
  • January 17, 2022

Wegovy (semaglutide) "Took it for 8 weeks, made it through the 2nd titrated dose and couldn't handle it anymore. Nausea, gas, bloat, constipation, diarrhea, and it was worse at night while lying down. Never improved, but actually got worse by week 8. Not sure how anyone makes it to the full dose. Also did not drop a single pound. There were days I only consumed 600 calories and still felt awful. I read another review very similar and agree that you absolutely cannot eat anything spicy. Bland food days were better but there are not enough antacids and constipation meds in the world to make me want to lose 20 pounds this badly. Took my last dose 10 days ago and am still dealing with residual GI upset. Hope physicians are more forthcoming about the side effects and do not tell patients they happen but subside in a couple of days - they do not."

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  • Kmac
  • Taken for 1 to 6 months
  • January 10, 2022

Wegovy (semaglutide) "First of all, this does work. I lost over ten pounds in 6 weeks. The weight just fell off. Second of all, this was the worst experience I have ever had with a prescribed medication. Well, I started at the lowest dose and took that for 4 weeks before moving to the next dose, which I believe was 0.5 mg. The maintenance dose is 2.4 mg, I believe. How anyone makes it to the 2.4 mg is beyond me. I made it to the second dose of 0.5 mg before I threw in the towel. This stuff is WICKED. I spent 6 weeks of my life with an upset stomach, the absolute worst reflux and heartburn I have ever had, and constant nausea. I had to literally force myself to eat. Would not recommend. The side effects and the price are not worth it. Easy to lose weight when you are starving yourself and feel too sick to eat. Once I stopped, it took a few days to feel better and the weight came back lightening quick plus a few. Not worth the misery in my opinion."

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  • AMano
  • January 2, 2022

Wegovy (semaglutide) "I’m on Week 15 of treatment and have lost nothing. On the first dose of 0.75 mg I experienced heartburn, fullness, and zero appetite for 5 days. I was hopeful that it had finally started to work. On subsequent doses of 0.75 mg and 1 mg, and now on 1.7 mg I’ve felt no effects from Wegovy. I’ve tried switching injection sites from my abdomen to my arm with no effect."

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  • Andrew
  • Taken for 1 to 6 months
  • December 5, 2021

Wegovy (semaglutide) "Does not work for me. I am on 1mg. Been on it a total of 2 months and 1 week and lost 5 pounds. Does not curb my appetite."

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  • Jane
  • Taken for less than 1 month
  • December 2, 2021

"I only did two of the .25 injections. They didn’t do much to suppress my appetite so I was looking forward to using the increased doses. However, both times, two days after each injection I got swelling and redness and a rash around the injection site. A week later the reactions have barely improved. One was in my thigh and one in my stomach. I discontinued use."

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  • Drdg
  • August 26, 2021

"I have been on this medication for two doses (.25mg) only and will not be continuing. Was taking it to help lose the 20-30 lbs that I need to lose and have never been sicker. The first week it made me feel slightly nauseous after eating. No matter what I ate or how much. Hours after the second dose I started with the worst and most violent diarrhea I’ve ever had. Up all night for the 4th night last night and cannot stay out of the bathroom. Horrible stomach cramps and I’m dehydrated from the constant bathroom use. Beware…if you’re not diabetic this drug might wreck havoc on your life. The rest of my doses are going in the trash. Just hoping these side effects pass after this week is up. It’s awful."

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  • Francam
  • Taken for less than 1 month
  • July 23, 2021

Wegovy (semaglutide) "This shot made me so sick for 3 days I have never been so nauseous in my life. Threw up the 1st morning after taking it. Never use it again."

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  • Angela
  • Taken for 1 to 6 months
  • July 22, 2024

Wegovy (semaglutide) "I started on 0.25 Wegovy. The injections are painless and easy to administer. For the 4 weeks, I took this dose, I felt fine with little side effects. I lost 3 lbs. I then moved onto 0.5 dose. I took the dose on a Friday and woke in the middle of the night with terrible sudden reflux and vomiting. This happened for 3 nights. I took my next 0.5 dose the following Friday and the same happened, along with dizziness, constant nausea, and very low mood. I have decided not to take the last 2 injections I have left as I just feel so poorly."

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  • Anonymous
  • Taken for 1 to 6 months
  • June 21, 2023

Wegovy (semaglutide) "I have lost 37 lbs in 3.5 months but should be more due to the horrific side effects. Burping, belching, vomiting, diarrhea, chest pain, nausea, blurry vision, basically every side effect imaginable. I never had side effects from any medications before. I continued to increase the dose up to 1.7mg and hope for the best with no success. I have three more weeks of misery but due to the cost of $586, I refuse to trash this medication."

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  • Xime
  • Taken for less than 1 month
  • June 19, 2023

Wegovy (semaglutide) "I started taking wegovy one week ago. I have had 2 injections of 0.25 mg. It feels like I have never been this sick before. Terrible cramps and diarrhea since day 3. I have heard about side effects but I was stubborn and wanted to try. I regret doing it. I learned my lesson. Needless to say I will stop the treatment. I am sure I have lost some weight. I am not retaining any food. A few minutes after eating, I have to go to the bathroom. I am glad to hear it has worked for many people. This medicine is certainly not for me."

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.