Entresto and Blood Pressure: What Users Say

• pau...
• Taken for 1 to 6 months
• July 7, 2021

For Heart Failure "Started Entresto in May and the side effects are bad, very low blood pressure, dizzy, weak, vomiting, diarrhea. I stopped taking and went back to old heart medication. Listen to your body, I thought I was going to end up in the emergency room."

• Fra...
• November 21, 2019

For Heart Failure "My husband was diagnosed with CHF since 2013, has been on Coreg, Lasix, and Lisinopril since. His cardiologist suggested he start on Entresto, half a pill twice a day to start. He ended up in the ER after taking the third dose! Low BP 83/54, weak, disoriented, almost delirious, very sleepy, had chills, and feeling very cold. His BUN and creatinine went up unlike he’s ever had. It was extremely scary! I almost called an ambulance because I had never seen him this way, not until he started this medicine. I read all the negative reviews before starting but still went for it. I feel bad that we did, and we are now waiting for the cardiologist's office to open in order to get him in for re-evaluation. Be extra careful and please keep a very close eye on your loved one, and if you see anything out of the ordinary for them, act immediately and get help. A very stressful situation. Be careful with this medicine."

• Osc...
• June 3, 2020

For Heart Failure "So my EF was 17 when my cardiologist put me on Entresto, and it went down to 13 within 1 month. I had to call 911 twice before my cardiologist took me back off it for critical shortness of breath and critical low blood pressure. I also experienced mental fogginess, blurred vision, and back pain while I was on Entresto. So my cardiologist put me back on Ramipril, and my EF went back up to 17, and I feel much better."

• woo...
• January 14, 2017

For Heart Failure "Took the 24 mg med and feeling lightheaded and dizzy. Blood pressure dropped to 60 and was sent to ICU for observation for several days. My potassium level went up to 6.9 and lab test results show kidney problems. The new cardiologist put me on Metolazone instead to remove excess fluid on lungs and it worked great! No more shortness of breath and no more swelling in the legs and stomach, and no excess fluid in the lungs. I advise to take a look at it first and do your research before taking this medication. Good thing I only took it for 6 weeks, but that short time did not give me good results."

• Mac...
• January 19, 2017

For Heart Failure "This drug is expensive. Patients on Medicare D can soon find themselves in the donut hole, thus causing added problems for many. (Not if money is no object). There is not enough information out on this drug's ability to prolong life. Doctor mentions very few side effects. Main ones were low BP, angioedema, high potassium/kidney damage. I bring up more side effects, he does not agree yet. Drugs.com lists side effects that I am having with this med. Back pain/side pain. I have had difficulty walking due to these pains and resort to a walker. Heart failure caused by poor stent placement in LAD. My EF is sliding downwards from 40-45% to recent echo of 30-35%. I thought this med was the answer to HF. Needing more solid info."

• Rob...
• Taken for less than 1 month
• October 21, 2021

For Heart Failure "After a severe heart failure in 2017, my husband was in a coma for 5 days. He was taken out of the coma, had a defib implant, HEF (heart ejection fraction) at 18%, and was discharged with metoprolol and Enalapril. Six months later, he is building a shed and feeling rejuvenated. The doctor changed Enalapril to Entresto, a new miracle drug for people with low HEF. This easygoing, laughing, funny man changed to a dizzy, weak-legged, extremely fatigued, despondent, depressed man. No energy, no stamina, no taste for food, can't bend over to put on shoes and socks, feeling like he is going to fall, up for a couple of hours, then needs to sleep for 4 hours, pulse in the 80s+, BP got as low as 63/41. Very low BP reading. Called the hospital, after a telephone conference due to COVID, advised to stop Entresto. Amazing, he feels back to his usual optimistic self, looking forward to a new grandchild, which he was thinking 'prepare for the time of death' planning! This drug might work for some, but not for 51% of people."

• Joy...
• Taken for less than 1 month
• June 7, 2022

For Heart Failure "I started Entresto for chronic heart failure. It did remove the fluid from my legs and feet, but I could not stand the chronic diarrhea, foggy head, muscle pain. I had more shortness of breath than I had before I took the medication. I fell because I was extremely dizzy, and my blood pressure was too low. I stopped taking it, and I feel a lot better than I did before. It just didn't work for me. I will be alerting my cardiologist."

• Dgf...
• Taken for 1 to 6 months
• December 10, 2021

For Heart Failure "Suddenly, one evening I couldn’t breathe, went to the ER and was diagnosed with CHF, dilated cardiomyopathy, pulmonary edema, and pneumonia. A 2D echo showed LVEF of 30-35% and I was started on a low dose of Entresto and have felt worse since being on it, with symptoms of chest pain, shortness of breath, increased PVCs, hypotension, dizziness, numbness and tingling in the entire body, with feelings of doom. After revisiting the ER two more times and one more hospital admission and still feeling worse, I realized after having taken Entresto for 3 months that my horrible symptoms began when I started taking Entresto. I stopped taking Entresto four days ago and am actually beginning to feel better, more normal. Know that Entresto is a great new drug for treating heart failure, but unfortunately I could not tolerate it ... the side effects outweighed the benefits for me."

• Not...
• Taken for 1 to 2 years
• May 6, 2019

For Heart Failure "36-year-old female put on Entresto to improve EF following postpartum cardiomyopathy. Unfortunately, after a year, I have not had any improvement in EF. I am at 45%. The drug doesn’t give me any side effects besides low BP when upon standing. I’ve heard great things from women with my condition. It seems my damage may just not be reversible."

• Hea...
• Taken for less than 1 month
• November 4, 2021

For Heart Failure "Caused heart to race. Brought BP down too low, 80/55. Felt I was hanging on for dear life. Got some water and a pinch of salt to help make BP go back up. Heart starting racing again, putting me back in A-fib, which was not a problem for the last 3 years. Not doing another cardioversion since the anesthesia wreaks havoc on my memory. No more Entresto!!!"

• Big...
• Taken for 1 to 6 months
• September 30, 2022

For Heart Failure "72 yr old male with heart failure. Had an echo that showed 40-45% for years. Dropped down to 30% and started to feel the effects after many years. Trouble breathing with any exertion. Cardiologist started me on Entresto and had 3 months of feeling worse, as it made my blood pressure get low. Got another echo to see if pacemaker eligible. I stuck with it, and after 90 days, I started feeling much better. The lightheadedness and extreme fatigue lessened, and I’m feeling much better. Latest echo showed 45-50%. Highest it has been since aortic valve replaced 18 years ago. Miracle drug, in my opinion. Took a while for my body to adjust to the drug, but I’m glad I didn’t get discouraged. Only drawback is on Medicare and gets very expensive when you fall into the gap. Very expensive. Will do without other stuff to continue to take, as it makes me feel so much better."

• Rgr...
• Taken for 2 to 5 years
• January 15, 2025

For Heart Failure "In 2022, at age 62, diagnosed with LVEF of 15. (Per Dr. most likely virus-related) Started on Entresto, metoprolol, spironolactone, and Farxiga. No improvement for 12 months. 13 months/2023 my EF increased to 47 and then 12 months later to 50. I was on the above regimen for 2.5 years. Had slight dizziness when I stood up and fatigue, very low blood pressure 80/60 and maybe brain fog. Old Dr., MD retired. New Dr., DO changed me to Valsartan/2024. After 2 months, my EF is 30. Dr. wants to stay the course and increase Valsartan and have Echo after 2 months. To be continued."