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Orlistat for Weight Loss (Obesity/Overweight) User Reviews

Brand names: Xenical, Alli

Rating: 7.4

Orlistat has an average rating of 7.4 out of 10 from a total of 385 reviews for the treatment of weight loss (obesity/overweight). 64% of reviewers reported a positive experience, while 17% reported a negative experience.

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Reviews for Orlistat

Commonly mentioned side effects
  • che...
  • Taken for less than 1 month
  • June 8, 2025

Orlistat "I've only been on Xenical for a few weeks and I'm impressed I've already dropped a couple of kilos. I walk one hour a day five days a week with ease... you're losing 30 percent of your fat in your body each time and when this starts to happen you're losing your weight... I've never taken diet tablets before but then I'd never been obese before so it's going great being on Xenical it really works..."

10 / 10
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  • rox...
  • Taken for 1 to 6 months
  • March 11, 2025

Orlistat "So I had a very good experience with Alli orlistat. I am so happy I have tried it. I'm still on them. I started like a month ago. I was 90 kilos. Everybody kept saying I'm fat. I got sick of that and said, let's try this. But I did research. I did not want injections, so from 90 kilos I am so excited I'm 83 and a half. I still have one more bottle to finish. Yes, some oily spots but not much. I just go to the washroom, but since I use Alli, I don't eat much. It helped me focus to eat healthy, so diet is a must. I cut back on bread. I use only keto bread, very tiny, like half a slice a day or whole wheat. I try no bread, so I'm on Alli orlistat and basically keto. I lost the belly fat, there is still a bit in 2-3 weeks. I'm focused to lose 3-4 more kilos. I am very happy I gave it a try with Alli. I might be skinnier. I was willing to try anything. I'm planning to buy smaller clothes and bathing suits, so thank you, Alli."

10 / 10
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  • Nat...
  • Taken for less than 1 month
  • December 9, 2024

Orlistat "Started on this medication 6 days ago, already lost 1.3 kg, for the first few days, there were no side effects, but then I regretted eating a piece of pizza as I was on the toilet all night. Noticed if I stick to the recommended diet, the side effects are less severe. Also seeing orange stains in the toilet, and that makes me feel sick even thinking about eating sweets or a high-fat diet. I am hoping to shed 20 kg, my weight was 89.300 when I started the medication, as of today, I am 87.600. My fear is when I stop not to regain all the weight back, that’s why I have to make long-life changes with my diet. These meds are also helping me to see hidden fats as I usually have nasty side effects. I am swimming twice a week and lifting weights. I hope I will build enough muscle in these 3-4 months to spike my metabolism."

10 / 10
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Frequently asked questions

  • Cec...
  • Taken for 1 to 2 years
  • October 6, 2024

Orlistat "I recently tried Alli as a weight loss aid, and my experience has been quite a rollercoaster. While I did manage to lose 50 pounds, which was a significant achievement for me, the journey was far from smooth. Unfortunately, the drug caused severe stomach issues that ultimately led to me needing my gallbladder removed. The initial results were promising, and I felt motivated by the weight loss; however, the ongoing pain was overwhelming. I found myself purchasing pills every month from CVS, but since the store in Dillon, South Carolina has closed down, I've been left searching for alternatives. If you're considering Alli, I urge you to think carefully and consult with a healthcare professional. Weight loss can be a complex journey, and it's essential to prioritize your health above all else. If anyone has questions or would like to share their own experiences, feel free to reach out via text."

10 / 10
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  • Ult...
  • Taken for less than 1 month
  • June 22, 2024

Orlistat "I've been on Xenical for nearly a week. Strangely, my stools are no different than before taking it, and my journeys to the toilet are normal. Is this normal? I'm sticking to the 5g fat per 100g rule so I will update later on any weight loss."

10 / 10
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  • Rac...
  • Taken for less than 1 month
  • May 19, 2024

Orlistat "I started this drug a week ago after losing 8 kg over 8 weeks through diet and exercise. I need to lose a further 41 kg, so my doctor prescribed it for me. The doctor didn't give me good instructions, and I feel the instructions that came with the pack aren't as thorough as I'd have liked, so I joined a Xenical support group on Facebook, which has been brilliant. I have stuck to three healthy meals a day, stuck to my TDEE recommendation for weight loss, ate less than 15 g of fat per meal (12 g or less to avoid the orange oil disaster!). One tablet with each of the three meals. In the first week, I have lost 4.1 kg, which I am more than happy about. I'm hoping I can continue at a similar pace. I've decided not to weigh myself until my review with my doctor in four weeks. It's been great for me so far, no accidents, no headaches, or stomach cramps. I would say drink plenty of water though, as I have been more thirsty than usual, but not excessively."

10 / 10
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  • Bes...
  • Taken for 1 to 6 months
  • January 3, 2024

Orlistat "I have lost 27 pounds on Alli over a five-month period. Mainly, it's aversion therapy. Nobody wants side effects, so you make common sense meal choices. Best success I have ever seen with any diet. I went from 137 to 110!!! I have also never had any extra side effects, like some have mentioned. Highly recommend!!"

10 / 10
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  • ama...
  • Taken for less than 1 month
  • November 10, 2023

"My doctor told me I have high cholesterol, and that I was a stone overweight. I have been on orlistat for 4 weeks and have lost 6 pounds. The medication stops you from eating fatty food, and basically if you do, you stink. I love my new diet. I cook fresh, healthy food. I am very pleased."

10 / 10
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  • Ann...
  • Taken for less than 1 month
  • September 7, 2023

"I lost 80 lbs in 2 months with this amazing medication. I also made sure I took a good vitamin. I watched what I ate and ALWAYS took orlistat within an hour. I took 120 mg per meal."

10 / 10
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  • jue...
  • Taken for 1 to 6 months
  • May 27, 2023

"I have been using Orlistat since the middle of February 2023. It is now the end of May 2023, and at this time, I have lost 17 kg. I have some days only taken two tablets, but mainly three. The only side effect I found in the beginning was if I had too much fat and would have an urgent need for the toilet. On a positive note, my appetite has decreased. If I'm not hungry, I have fruit, and I don't eat between meals anymore. I feel healthier all over, and inches seem to be melting away. I have yo-yo dieted for over 20 years, and this has helped. I give it 10/10."

10 / 10
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  • Ali...
  • Taken for 1 to 6 months
  • May 13, 2023

Orlistat "I haven't lost weight, only 0.5 kg, but my aerobic endurance improved drastically, so I recommend this medicine for visceral fat."

10 / 10
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  • Sal...
  • Taken for 6 months to 1 year
  • May 4, 2023

"I’ve lost 4 stone, 13 lbs so far in 7 months. Had one accident, but washing up liquid saved the day and got the orange oil out of my new jeans. I feel fantastic, my skin is better. I had developed obesity-related acne, and it’s gone. I’m back in size 14-16 and feel like I can move again. I think this medicine is working for me because it has broken my psychological self-sabotaging barrier to weight loss, where one blowout would knock me off the rails. I can have a takeaway, eat chips, and enjoy it, and then enjoy flushing it all away the next day. So long as it’s not every meal, I still consistently lose weight. I find it so satisfying seeing pools of oil in the loo (sorry!) knowing that’s not in my body, and I’ll still lose weight. It’s changed my life, I’ve never lost anything like this amount of weight before, and I’d really recommend it to anyone! :-)"

10 / 10
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  • MB2...
  • Taken for less than 1 month
  • January 28, 2023

Orlistat "Started taking Xenical 1 week ago and lost 7 lbs in one week. Haven’t yet had any form of accidents, however, I have completely changed my diet to low fat and added 45 minutes of walking 5 days a week. I did experience headaches for a few days, which have now completely passed. I have been eating 1,200 calories daily (roughly) and found this to help. Have also experienced constipation if taken with a meal that’s between 2-5 g of fat."

10 / 10
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  • Ane...
  • Taken for less than 1 month
  • November 15, 2022

"I’ve started to use Orlistat a couple of weeks ago, and I already lost 2 kg. One thing you need to keep in mind is that you have to follow a low-fat diet, otherwise, you’ll get the embarrassing accident mentioned in previous reviews. If you use it as it’s prescribed, you don’t have to worry about the side effects. I hope it helps."

10 / 10
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  • JS2...
  • Taken for less than 1 month
  • October 21, 2022

"I am a woman in my early twenties with PCOS, so my weight loss is difficult due to what I’m assuming is hormone issues because my diet and exercise habits are good. I’ve been taking Orlistat for less than a week, and I’ve already lost 5 lbs with the diet that I have been doing!!! I normally don’t eat fatty foods, and I avoid alcohol and sugary drinks. I went out with friends one night and did eat wings. Well… I woke up at 2 a.m. regretting every single decision I had made up to that point. I will definitely not be doing that again lol, but overall this medication has helped me go from 217 to 213 in a matter of days. I do also regularly work out, so I’m excited to keep taking this and see better results months from now. Now I’m convinced it is my hormones that made it difficult to lose weight because I haven’t changed my diet and exercise since taking the pills. So for my PCOS girlies, please give it a try!!"

10 / 10
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  • Kat...
  • Taken for less than 1 month
  • September 28, 2022

Orlistat "Had a good scare with a hemiplegic migraine, which I know is related to my post-postmenopausal pounds that packed on. In 2 years, I have gained a bit over 40 pounds. Finally, the doctor gave me something to help me, and this being my 4th morning of Xenical, I am down 7.2 pounds eating 3 times a day: low cal, no sugar. No side effects, thank goodness. Head is feeling better, and I have noticed my achy bones are not giving me such a hard time this morning! Side note: eating roughly 1200 calories and maxing at 26 grams of fat daily, no snacking so far."

10 / 10
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  • Pud...
  • Taken for less than 1 month
  • March 11, 2022

"I wrote this to help others looking at reviews before buying. I have tried all fad diets, never work, and I never stick to anything as I can’t control what I eat - I love snacking! Anyway, I bought these off the cuff, and wow."

10 / 10
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  • Sup...
  • Taken for 1 to 6 months
  • February 10, 2022

"Take-home message is that this tackle works, and works well. On the downside, had I known taking a bit of a gamble on an iffy fart while walking around Waitrose would turn out to be quite so catastrophic, then I’d have taken drastic steps. I also wouldn’t have been wearing white rugby shorts. Low point in my life, the ignominy of having to dash to the toilet with turd-oil down my leg was the turning point. I quickly learned that the way to stop making the back of my boxers look like a dropped lasagne was to stop eating the rammal that had turned me into a fat idiot in the first place. Within a few days, each fart became less of a gamble, and each parting company on the toilet looked slightly less like I’d tipped a bucket of Sunny Delight mixed with 5w30 oil down it. Don’t get me wrong, it’s going to be a good while before I have the confidence to show any level of enthusiasm on the trumping front, but I did manage this morning to do one I could hear without washing my gooch."

10 / 10
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242 Report
  • Sta...
  • Taken for less than 1 month
  • January 23, 2022

Orlistat "Brilliant from Wednesday to Sunday on this. I lost 3.5 kg, which is 7 lb! I have none of the bowel problems people have complained about and no issues at all with the medication. I was worried as I usually struggle with new tablets, but these are great. No side effects for me. For reference, I'm 5 ft 8 in and I was 91.5 kg, and I'm now 88 kg in 5 days. Obviously, some will be water weight, but I'm very happy."

10 / 10
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  • Mol...
  • Taken for 10 years or more
  • November 1, 2021

Orlistat "I have been on three 120 mg Xenical daily on prescription, plus diet and exercise. I have been a yo-yo for 12 years in good faith, I cared. Xenical has not worked for me, I have not lost any weight or fat. GP cares, I care."

10 / 10
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3 Report
  • Bel...
  • Taken for 1 to 6 months
  • October 21, 2021

"Been using Orlistat 120 mg for nearly two months. I’m peri-menopausal, and nothing was shifting the weight. I’ve lost 1.5 stone, a dress size smaller, and got my waistline back. Yes, you poo oil, but if anything, it’s helped with my IBS. I’ve been healthy eating through the week, but at weekends, I eat occasional takeaway and treats. I don’t overdo it, but I don’t deny myself. No exercise, as I’m always on the go, so imagine the weight loss if I did! I feel like this medication has been a miracle for me."

10 / 10
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  • My ...
  • August 27, 2021

"Orlistat is very good so far. I have it after gaining a whopping 3 stone in pregnancy, which made me obese. I'm 5ft 3in. My little one is now 16 months. I managed to lose a stone and a half, then it all plateaued, and for my BMI, I was still classified as obese. I have only had minor side effects due to only taking 1 a day in the morning, I will slowly get it up to 3 if I need to. As a single mom, I can't risk the side effects just yet. I have been on it for 6 days, making healthier choices and just walking as much as I can, and have lost 3 pounds, so I'm very happy and do not feel the need to take more than one a day. At the moment, I would definitely recommend it, it gives you that extra boost, but if you are worried about side effects, just start off small. I'm still losing weight."

10 / 10
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  • lad...
  • Taken for less than 1 month
  • August 12, 2021

"Orlistat weight loss aid is excellent for those on a low carb high fat diet. I saw that it was working 24 hours after taking my first capsule. If you don't eat fat, you won't lose fat with this med, so a high carb diet will not produce good results."

10 / 10
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  • Ora...
  • Taken for less than 1 month
  • July 21, 2021

"I have started Orlistat only 3 days ago! I have had it prescribed from the GP as I can’t shift weight at all, tried loads of diets!!! Pleased to say no nasty effects (did notice the oily stools, have been going to the toilet only once a day, max twice). I have lost 1 kg already!! I am following a low-calorie diet too, so let’s be positive! Scared to eat rubbish as I heard you can have accidents, lol! So I have been a good girl and no accidents so far!"

10 / 10
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19 Report
  • Luc...
  • Taken for 1 to 6 months
  • July 7, 2021

"I've been on orlistat since May 2021, and today (July 2021), I got weighed at my doctor's surgery, and I've lost a whopping 2 stone in 7 weeks!! I feel fantastic and will continue to use orlistat to help me lose my weight. I haven't really changed a lot in my diet except I've stopped snacking on junk!"

10 / 10
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185 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.