Midodrine User Reviews & Ratings

• Ben...
• Taken for 1 to 6 months
• October 22, 2022

For Postural Orthostatic Tachycardia Syndrome "Again, unfortunately, not all drugs work well in some. I am 91 years old and was put on midodrine x 3 daily for hypotension (the doctors have only realized I have an underactive thyroid). Side effects of midodrine were dizziness and falling over (broke my back and knee; was told it was age-related), severe anxiety and confusion (was told I have the beginning of dementia), couldn't talk due to breathlessness (was told I have heart failure and COPD - never smoked or drank), and had a heart scan and X-ray 1 month before starting midodrine, no heart problems. Burning all over, insomnia (walking around the house in the middle of the night confused), cramps all over my body (was told I have osteoarthritis), lack of appetite (was told it was age-related). It's a shame doctors, etc., don't want to know or help when you reach a certain age and just tell me I have heart problems, dementia, and osteoarthritis. My grandson stopped the midodrine, and within two days, ALL the above symptoms magically disappeared."

• HS0...
• August 13, 2014

Midodrine for Postural Orthostatic Tachycardia Syndrome "I take 10mg midodrine three times a day for Postural Orthostatic Tachycardia Syndrome. It has changed my life completely. I'm able to be active and do all the things I used to avoid. I go to concerts, movies on opening night, and shopping at places with long lines. I can date without worrying about whether we're going somewhere that I'll need to stand still. There are side effects - weird sensations and goosebumps mostly. The benefit far outweighs any negative effects or risks."

• Anonymous
• July 20, 2011

For Hypotension "I have been on this medicine for thirteen years (since age 17) without issue. Taking this medicine enables me to live my life with only the occasional (rather than inevitable) fainting, dizziness, and exhaustion. My doctor tried to switch me to lower doses, but my symptoms immediately kick in and make it difficult to function. Regular doses have made all the difference in my life."

• Liz...
• Taken for less than 1 month
• October 14, 2019

For Hypotension "This medication raised my heart rate, and it dropped my blood pressure and landed me in the emergency room for 3 days! I remember taking it and feeling the urge to pee, then I have this burning sensation all over my body, then the dry mouth kicked in, and then convulsions and weak legs, then the tachycardia and faint feeling, then the panic set in, and the flushing and burning in my ears, severe pressure in my head, abdominal cramping, and finally severe dizziness. It was the worst thing I had ever tried...! I was very upset at the way I reacted to it."

• Sus...
• Taken for 1 to 6 months
• December 26, 2018

For Dysautonomia "I give it an eight because it's not for everyone and because I do get side effects like irritable mood, more headaches, body pain, and stomach upset, but aside from that, it is a life-changing drug. I am no longer fainting 4-5 days a week. I can stand up for more than 30 seconds without fainting. I can think. I can be active for 4 or more hours per day instead of 1-2. I can drive a car without getting tired and confused. It has given me my life back after 24 years of not living!"

• Le ...
• Taken for 1 to 2 years
• March 9, 2014

For Dysautonomia "I started taking Midodrine early last year and, like others before me have said, it's the best thing since sliced bread! I had to get out of the military because of bradycardia and vaso-vagal syncope, and I was taking fludrocortisone at the time. The Florinef was awful, my hair was falling out, my nails were tissue-paper thin (and painful), and I was still passing out every time I stood up. Midodrine has allowed me to do the things I love! I am a serious bowler (trying to go pro), and without this awesome stuff, I wouldn't be able to bowl more than one game (and very slowly) without passing out. I can also take showers standing up! *GASP!* What a concept! It's a lovely medication! My only quibble is the tingling on my head."

• kee...
• August 17, 2010

For Hypotension "I am greatly disappointed that they are going to take Midodrine off the market. I have taken it for about 8 years with fantastic results. Without it, I have syncope often. I am really researching what to do because I rely on this medicine for help with my hypotension. I tried to go off of it once and passed out in my boss's arms, which was embarrassing. I got back on it, and not had a problem since. Even on medication, my blood pressure runs 100/70, but off of Midodrine, I have to work to keep it at 88/60, sometimes, it is less than that, and syncope is definite. I WISH they would reconsider taking it off the market."

• Lif...
• Taken for 6 months to 1 year
• February 17, 2023

For Postural Orthostatic Tachycardia Syndrome "Midodrine gave me my life back when I was ready to give up. I'm a 33-year-old woman and take 5 mg three times per day, and now I can think clearly, stand up without having to brace myself to prevent fainting. I can stand through 95% of my showers now (was sitting most of the time before). I can walk (even up stairs) at a normal pace without getting completely out of breath. My chronic fatigue and brain fog have dramatically improved. I don't feel the blood draining out of my arms when I lift them above my heart or feel blood pooling in my feet anymore. Even my hair started growing again, and my acne has improved. This has literally been life-changing for me! My body feels a level of peace I've never experienced before. I never got any of the negative side effects others talk about, like goosebumps or tingles. However, the first 3 days on this, I felt really weird and almost quit, but I'm glad I pushed past that and adjusted. I will never be without Midodrine again. It makes life worth living."

• Nik...
• Taken for 1 to 6 months
• October 20, 2020

For Hypotension "I suffer from both hypotension (70/40 on a good day) and chronic fatigue syndrome. I needed to get surgery on an unrelated issue, and we were worried about my blood pressure. So my doctor decided to try midodrine 10 mg, up to 3 times a day. Without exaggeration, this saved my life. I can now not only sit up but stand without passing out. Furthermore, I can stay awake like then 3 hours a day. Does this give me chills and goosebumps? Yes. But my goodness, I have my life back. I'll take the goosebumps and wear a sweater."

• lvn...
• September 29, 2009

Midodrine for Dysautonomia "This medication gave me back my life. I was passing out everywhere. People in Target hated to see me coming. I passed out in a parking lot and prayed I wouldn't be run over. I had hypotension and vaso-vagal syncope upon movement. This didn't 'cure' it, but helped me so much."

• Cha...
• Taken for 1 to 2 years
• August 31, 2024

For Hypotension "I take 60 mg a day of midodrine (20 mg x 3/day), and prior to ever taking it, I was barely able to do anything from standing, walking, sometimes even just sitting without passing out. Life was getting pretty dark, to say the least, as not only mentally and physically but also financially, as I was unable to even work. It took a little bit for my body to acclimate to the medication, but now I can work, walk around, sit. I still have trouble standing in one place, and it doesn't quite hold for a full 4 hours in between doses, but it's truly been a miracle for me. Some side effects being my head itches, and sometimes it feels a funny sensation. I get what feels like popping skin crawls (not quite goosebumps), and I don't feel cold. It's enough to make me giggle. The reality of what it used to be vs. the open possibilities now makes all of it worth it to me."

• tog...
• October 3, 2015

Midodrine for Postural Orthostatic Tachycardia Syndrome "I have been diagnosed with dysautonomia and postural orthostatic tachycardia syndrome and many other things, but this medicine was my only option. I can't take beta blockers because I need to be able to use my epi-pen, and I had a bad reaction to Florinef, so we decided to try midodrine. It is a lifesaver! I can't go anywhere or do much of anything if I don't take it. I will pass out if I'm not on this medicine, I'm very pleased! I do have to deal with flushing and frequent headaches, but it's very much worth it, the cost."

• Bar...
• Taken for 1 to 6 months
• July 26, 2024

For Hypotension "I was taking 2.5 mg three times a day for my hypotension until my BP rose to 184/89. Then my GP reduced it to a half three times a day or two as required, which appears to be working fine now. My low BP had been down to 60/40ish, so seeing it around 120/70 cheers me no end, even though the frequent urination, feeling sick, and confusion, plus leg muscle pain, enabled my GP to find an alternative to midodrine. I was taking fludrocortisone, which put me in the hospital twice."

• Ddo...
• August 17, 2010

Midodrine for Postural Orthostatic Tachycardia Syndrome "ProAmatine is the best thing since sliced bread! Without ProAmatine, POTS patients like me would not be able to function! The side effects are minimal and short-lasting (they usually go away within the first week), and it gives people their lives back!"

• dan...
• April 14, 2023

For Hypotension "I was prescribed 2.5 mg three times per day. I got pretty intense side effects from that dose, so I cut those in half and took two pills per day, four hours apart. So, yes, they do work as far as finally not feeling like passing out when I go from sitting for a while to standing up. That's great! I feel like the side effects are intolerable for me though! Even taking a tiny amount now, I have terrible chills all day, and my skin crawls and tingles constantly, making me nervous and woozy. One day, my heart was pounding so badly, causing my whole body to shake, which made my body even more numb and pinprickly, that I went to the ER thinking I was having a stroke or something. They told me I had anxiety and low potassium (I'm thinking that was from the constant peeing from this medication). So I don't know what to do now. I like the positive of not feeling lightheaded, but the tingles, anxiety, and all might not be worth that benefit."

• Anonymous
• February 24, 2010

For Hypotension "It significantly improved my mother's quality of life. She is a heart and renal patient, and due to low blood pressure, she was always feeling dizzy and was unable to carry out simple tasks at home. She was always sitting or lying down. Since this medication was started, she has improved a lot without experiencing any side effects. Positive result with this medication. It should be licensed."

• jam...
• November 6, 2010

For Dysautonomia "After trying a few other drugs in combination, adding midodrine was what enabled me to get out of bed and sit up without fainting, dizziness, and drastic hypotension. I can now stand and walk, and participate in life when before, I was bed-bound. Yes, I now have very itchy, sensitive skin and scalp; but I will gladly suffer that slight annoyance to be able to function. I am glad it's a shorter-acting drug, even though I have to dose in the middle of the day because it gets out of my system before I go to bed and don't change from hypotension to hypertension."

• Fro...
• Taken for 1 to 6 months
• March 29, 2025

For Hypotension "I have medication-induced hypotension from taking risperidone. It got to the point where I couldn’t even stand up without fainting or near fainting. I didn’t want to come off the medicine because it worked so well for all my symptoms, so my doctor added midodrine. This medication gave me my life back. I know there are others out there that are going through the same thing who are on antipsychotics, so have a talk with your doctor and try it. I’m not saying it’ll work for everyone, but it’s worth giving it a shot."

• tri...
• May 17, 2017

For Dysautonomia "If there's a side effect to be had from a drug, I'm the type to get it, but other than initially making me nauseous, this medication is not one I can go without! It has allowed me to function from debilitating dysautonomia. While I'm not 100% yet, it has helped me get my life back. Started on 2.5 mg three times a day, but I am up to 15 mg three times a day."

• Lau...
• Taken for 6 months to 1 year
• October 23, 2024

For Hypotension "I have orthostatic hypotension, and midodrine has given me my energy back. I can do household chores and hygiene tasks far more easily, and my thinking is clearer as well. Whenever my dose was increased to get me to my current level, I experienced some chills and scalp tingling for two weeks, and then that side effect disappeared. I’ve had no other side effects. I do take it 4 times a day because of the relatively short effectiveness."

• Dai...
• February 16, 2018

For Hypotension "I was prescribed this following 18 months of fainting, exhaustion, low blood pressure. The first time I managed a month before becoming very depressed. I was so down that my family were really concerned. I stopped it but then decided to try again when completing a month's cardiac monitoring that my consultant wanted (I hadn't mentioned the side effects). Again, within a week or so of starting, I began to feel extremely low and depressed. My blood pressure had improved, normally around 85/50, but the bad far outweighed the good!"

• Kay...
• Taken for less than 1 month
• November 3, 2015

For Hypotension "Was prescribed for fainting/low blood pressure. I started taking this, and it made me have involuntary facial expressions, and I started fainting repeatedly. Allergic reaction, so I had to stop using it immediately."

• EDR...
• Taken for 1 to 6 months
• May 19, 2018

For Hypotension "My neurologist put me on this midodrine. I couldn’t stand and walk 5 ft without going down. I was getting ready to accept life in a power chair. I have CIDP (Chronic Inflammatory Demyelinating Polyneuropathy). I have lost 60% of the nerves in my legs due to severe neuropathy. The blood vessels do not get the signal from my brain to constrict just before I stand up, so the blood drains down and I go down."

• Jon...
• Taken for 1 to 6 months
• December 9, 2024

For Hypotension "A year ago this past May 29th, I woke up in the middle of the night weak and disoriented. My husband took my blood pressure and it was 54/42. He was concerned and headed me to the hospital an hour away. I was in and out of consciousness all the way. When we arrived at the hospital, I passed out after they got me into a wheelchair. By the time they got me back and took my blood pressure again, it had bottomed out. I almost did not make it. When I woke up, I was in a hospital bed in a hospital gown with no recollection of what went on. My family doctor was concerned as my blood pressure was pretty low. Up until this happened, it was around 127/80. He sent me to one of the best hospitals in eastern TN, Vanderbilt. They were not able to pinpoint why. Now that I am taking midodrine, my blood pressure averages around 103/74, pulse 80-100, and I’m not tired all the time. I only take it 2 times a day as the side effects of lightheadedness bother me."

• Ano...
• March 22, 2023

For Postural Orthostatic Tachycardia Syndrome "I was on 10 mg midodrine for years for my P.O.T.S. I’ve had this condition for 17 years and am now 70. When I started taking this script, it cost me $450.00 a month! It was extremely hard to come up with that cash, but it was the only thing that worked. (I also take 5 mg of nadolol.) I take 10 mg every 4 hours in the daytime and sleep in a head-elevated bed. My blood pressure rose too high last year, and my doctor took me off of it. It was a struggle. I am back on it now because I had an infection, and every time I get sick, POTS returns with a vengeance. I do feel the itchy and tingly scalp, but that goes away as time goes on. My cost is very reasonable now that I’m on Medicare. I can put up more with this med but still can’t drive because I feel like everything is shutting down, and I can’t concentrate on the road. I never want to be without this medication. It doesn’t make me as strong on my feet as healthy people my age, but at least it is a good crutch for a more normal life."