Leqvio and Stiffness: What Users Say

• She...
• Taken for 2 to 5 years
• October 26, 2024

For High Cholesterol "Two weeks after my first injection, just out of the blue, my right hip started aching. Then it got to where it felt like it was catching and caused a sharp pain, keeping me from walking correctly. X-rays showed arthritis, but it still bothers me. Then my legs started burning, tingling, and hurting, and by the end of the day and when I first get up in the morning, I am so stiff. I’m due for a 5th injection in December, but I’m seriously thinking of canceling it. My cardiologist will probably throw a fit. It has lowered my cholesterol level a lot, but I’m tired of being in such pain just to go grocery shopping."

• Lin...
• Taken for 1 to 6 months
• August 25, 2024

For High Cholesterol, Familial Heterozygous "First off, I do have fibromyalgia and Sjögren’s, but after the first shot, the pain definitely went up, and I had chronic bronchial congestion. After the second shot two months ago, the pain accelerated in my knees, feet, legs, sides, chest, shoulders, and wrists. And I still have lots of congestion. I attributed the severe pain to the injection which, of course, as many say, did really help my cholesterol numbers greatly, but my next shot is in December, and I think I may not bother with it as the pain and anxiety that I attribute to the shot are not worth it. Reading these reviews and other reviews of this drug, it sounds like it just causes incredible mental muscle stiffness and congestion for many people. It works well for what it was designed to do: lowering all the numbers, and I appreciate that, but this is tough being in pain."

• Wil...
• Taken for 6 months to 1 year
• December 20, 2024

For High Cholesterol, Familial Heterozygous "The drop in my total cholesterol number was dramatic the first 90 days. Dropped from about 280 to 155. My LDL dropped from something like 90 to 55. Won't have the second blood work until two months from now. Side effects: The most aggravating side effect was not diarrhea, but overly soft stools. The overly soft stools cause big-time hygiene problems. This side effect started about two weeks after the shot and continued for about a month. After the second shot, the very soft stools began around two weeks following the shot and continued off and on for a few months. Very, very aggravating. I may have had at times a slight increase in having to urinate. Barely noticeable, but it did happen, and I can't say exactly when that began or tapered off. Haven't had (so far) any undue muscle aches or stiffness."

• pau...
• Taken for 6 months to 1 year
• June 20, 2024

For High Cholesterol "Two shots so far. Both times, worse stiff toes and ankles, low back pain, stiff neck, and shoulders. First time, these resolved in about a week. Stiff toes and ankles never resolve completely along with numbness in feet as a result of taking statins. Deemed statin intolerant, which is why trying the Leqvio shot. Odd side effect both times is eye irritation that feels like a stye coming on but never develops. Doing blood work to see how results are with two shots and low-fat lifestyle (down 25 lbs, weigh now what I did in my 20s). It better help or not sure all this is worth it! (Recommend with the caveat of the above)"

• Eli...
• Taken for 1 to 2 years
• May 22, 2024

For High Cholesterol "Had high hopes, but too many gastrointestinal side effects. Also muscle pain and stiffness. Lowers cholesterol but 2 months after the shot, I still have side effects."