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Tri-Sprintec and Mood Swings: What Users Say

Mood swings: mentioned by 187 users (22.2%)

Based on user experiences from 841 Tri-Sprintec reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

acne 23.4%
nausea 22.5%
mood swings 22.2%
weight gain 18.4%
depression 15.8%
cramps 11.7%
anxiety 10.9%
headaches 10.9%
sore breasts 8.1%
sexual dysfunction 7.8%

Reviews for Tri-Sprintec

Commonly mentioned side effects
  • Lil...
  • June 7, 2016

For Birth Control "I have had absolutely no problems with Tri-Sprintec. I don't have any side effects at all. No weight gain, no mood swings, no depression, no anxiety, no nausea, same sex drive. (No increase in breast size either - I WISH I had that side effect!) I feel exactly the same taking this as I did not taking any birth control. The only difference is my periods are lighter and shorter, and my cramps are no longer severe. By the way, I was really scared to take this because of the negative reviews I read! But before you decide this is a bad pill, give it a try. Every woman's body is different, and your experience will just depend on your body!"

10 / 10
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50 Report
  • Bug...
  • Taken for 6 months to 1 year
  • February 28, 2020

For Birth Control "So I've been on this pill for 9 months. It's given me really bad mood swings, depression, etc. I almost feel manic depressive on it. The hormone levels change drastically throughout the pill pack, which is why you get mood swings. Look for a monophasic birth control instead - going off this drug now. It worked on the whole no-pregnancy bit, and my periods were very short and light. No acne either. But I'd rather not feel crazy."

2 / 10
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33 Report
  • Ano...
  • Taken for 1 to 2 years
  • July 16, 2019

For Birth Control "Every birth control pill will react differently to each of our bodies! The best thing to do is to just try it out and stop taking them if we see changes we don’t like. I personally LOVE this brand. My experience is awesome! I was never regular, so it has helped me get my period every month. My mood swings are normal, but I feel more energetic, I lost weight, and I feel better than ever! Sex being involved, we all know that nothing is 100 percent accurate, but I had unprotected sex with my partner over a year, and I’ve had no surprises, thankfully. Continue the routine with a pill and see if you could either love it or hate it! Glad to give another opinion and make the best decision that suits your body(:"

9 / 10
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31 Report
  • Anonymous
  • Taken for less than 1 month
  • May 1, 2020

For Ovarian Cysts "I just started this pill, Tri-Sprintec, 2 days ago for ovarian cysts, and I have high hopes for it. I went through so many doctors who told me everything was fine with me, but I knew something was wrong. Finally, I found a doctor that actually ran the blood tests for me and diagnosed me with PCOS. I’m 27, I can’t believe it took this long for someone to listen! Anyways! I was dealing with extreme anxiety and constant agitation for years, and starting this pill, I finally feel normal. Thank God! No mood swings and mini rages. I’m excited to finally have something that works for me!"

10 / 10
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26 Report
  • Laf...
  • February 27, 2014

For Birth Control "I have been on this pill for about a month and a half. I gained 20 pounds in about a month without changing my diet. I have been a complete antisocial freak who doesn't want to do anything besides sleep and be alone. My period was terrible, and I went from having sex with my boyfriend 2-3 times a day to 2 times a week. I have been to a therapist because of how emotional I've been, and I have wanted to drop out of college. The only 'semi' good thing about this birth control is no babies and huge breasts. I went from a C to a DD, which my boyfriend loves, but me not so much. I am getting off of it."

2 / 10
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39 Report

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  • hon...
  • May 9, 2010

For Birth Control "I am currently 19, in good health, not taking other medicines, have been tested negative for STDs, and sexually active with one partner only. I am taking birth control mainly as a contraceptive and partly to regulate my irregular periods. I have just completed my first week on Tri-Sprintec and have not experienced any significant changes. I have not had any mood swings in the past week, nor experienced drops/spikes in libido. No significant weight gain in this past week, however, I do feel my sports bras tightening up. (Hopefully, my breasts are growing?) No breast tenderness. No change in appetite. Complexion looks better if not the same. I will continue to share my experience with this pill. Currently, very happy with it."

8 / 10
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39 Report
  • No...
  • September 4, 2009

For Birth Control "I am 28 years old. I have never felt any side effects from any birth control I have ever taken. My doctor, however, switched me to this one because of the price, I assume. Since I began taking it a month ago, I have been extremely emotional, crying when I'm happy, crying when I am sad. My mood swings are having an effect on my relationship, my kids and husband, as I am less patient and more tired. My face is also breaking out, which normally only happens when I am PMSing the week before my period. I called my doctor today to switch me off of this. I am only stating my experience to reassure others if having the same side effects that it is not you coming down with depression. It is only the pill."

4 / 10
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37 Report
  • No...
  • September 4, 2009

For Birth Control "I am 28 years old. I have never felt any side effects from any birth control I have ever taken. My doctor, however, switched me to this one because of the price, I assume. Since I began taking it a month ago, I have been extremely emotional, crying when I'm happy, crying when I am sad. My mood swings are having an effect on my relationship, my kids and husband, as I am less patient and more tired. My face is also breaking out, which normally only happens when I am PMSing the week before my period. I called my doctor today to switch me off of this. I am only stating my experience to reassure others if having the same side effects that it is not you coming down with depression. It is only the pill."

4 / 10
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37 Report
  • Han...
  • Taken for less than 1 month
  • May 19, 2020

For Birth Control "So I've been on it practically a month, I have 5 pills left. First week, I was super emotional, so I decided to take it at night, and that worked a lot better for me. I stopped getting random mood swings. My skin is a lot clearer now. Downside is I just had my first period on it, and I've been bleeding for a week and a half. It was light at first, and then it got really heavy. I'm on my 10th day on my period, and it's like a massacre, it won't stop. I'm hoping it ends soon, and my next period isn't as heavy, but if it continues, I will probably switch. I've also had really bad cramps during this whole ordeal."

7 / 10
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15 Report
  • Han...
  • Taken for less than 1 month
  • May 19, 2020

For Birth Control "So I've been on it practically a month, I have 5 pills left. First week, I was super emotional, so I decided to take it at night, and that worked a lot better for me. I stopped getting random mood swings. My skin is a lot clearer now. Downside is I just had my first period on it, and I've been bleeding for a week and a half. It was light at first, and then it got really heavy. I'm on my 10th day on my period, and it's like a massacre, it won't stop. I'm hoping it ends soon, and my next period isn't as heavy, but if it continues, I will probably switch. I've also had really bad cramps during this whole ordeal."

7 / 10
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15 Report
  • Anonymous
  • April 8, 2009

For Birth Control "Well, I'm an 18-year-old teen just trying to be safe and smart, but continue a normal life with little side effects, and this pill definitely did that for my twin sister and me. We love it. It's small and easy to swallow. No mood swings, no cramps, no sleepiness, or confusing abnormal bleeding that worries you for days. It's wonderful. We both recommend this to whoever is looking for a reliable contraceptive pill."

9 / 10
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36 Report
  • Anonymous
  • December 7, 2013

For Acne "I'm 22 years old and have been dealing with acne since about 13 years old. I've been on Tri-Sprintec for almost two years now, and what a difference. It has to be the best birth control I've ever been on. No gaining weight, mood changes, and my face stays clear even when it is that time of the month. Life changing."

8 / 10
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27 Report
  • Evi...
  • Taken for 2 to 5 years
  • December 30, 2015

For Acne "PLEASE READ THIS: Tri-Sprintec will cause an initial breakout for the first 3-4 months. DON'T BE DISCOURAGED! After this period, your skin will clear up like magic! I'm 20 years old and have been on Tri-Sprintec on/off since I was 18. I've had severe acne since I was about 12/13 years old and have seen multiple dermatologists since then. Nothing worked until I went to my gyno to get on birth control, and she recommended Tri-Sprintec because it helped with acne. At first, I felt mild nausea and severe depression/mood swings/etc., but as time passed, this went away. Each time I got back on the medication, I would have a terrible breakout period, but it's completely worth it. This is a great pill, and I've never had problems with it."

8 / 10
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22 Report
  • Anonymous
  • March 3, 2010

For Birth Control "Tri-Sprintec was the first birth control pill I used. I chose it because I was told it would help with acne. (And obviously as a contraceptive). At first, Tri-Sprintec was good for me, it helped my acne (it didn't completely go away), and my boobs got bigger! And well, I wasn't pregnant. However, after two months, I began to notice myself having mood swings. This was so strange for me because I am such a relaxed, chill person. I couldn't ignore that I was moody. Little irrelevant things that happened with my boyfriend would make me very sad/mad, and well, I don't think I've ever cried as much as I did when I was on this. It was beginning to interfere with my relationship, so I stopped taking it. This was just me, so it may be different for you."

4 / 10
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30 Report
  • JDW...
  • Taken for less than 1 month
  • January 4, 2014

For Birth Control "I started Tri-Sprintec a month ago, not by choice but because that was the only thing the health department had in their inventory. The nurse told me it was exactly the same as the other pills. I could definitely tell a difference in myself, though, just after starting them! My emotions were out of control, and I kept going into deep depression mode! My appetite was pretty much gone too, so I wasn't eating. A good tip is to keep a journal once you start a new pill, so you can keep track of breakdowns, mood swings, and how often they're happening. I had a breakdown at work, crying in front of my boss and everything. I decided to stop the pill, and since then, I've felt great."

4 / 10
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23 Report
  • sch...
  • Taken for 1 to 6 months
  • April 17, 2014

For Birth Control "I had a baby girl 6 months ago, and I started this about 2 months ago. At first, I was doing great with it, but then, after about 2 weeks of taking it, I have really noticed some not-so-great changes in me. My chin is constantly breaking out, so it did not help clear up the acne. I have really had some bad mood swings of just feeling really sad, and my anxiety has been pretty bad. It has really messed with my sleeping patterns. I also gained about 16 lbs from the time I started taking this pill until now. I wear contacts, and it really seems to dry my eyes out and make my vision a little blurry, which I haven't really had much trouble with before. I am seeing my doctor soon, and we are planning on switching me to another birth control pill."

6 / 10
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22 Report
  • Anonymous
  • Taken for 1 to 6 months
  • August 25, 2012

For Acne "I was very skeptical about trying this pill because it is a generic, and I have heard negative things about it. I have been on it for two months, and so far, no weight gain, no nausea, no mood swings, or any other of the reported side effects. The best part about this pill is that it completely cleared up my cystic acne after only a few weeks. I have been on a couple of other pills with horrible side effects. Find the pill that works best with your body. This one seems to work best with mine."

10 / 10
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23 Report
  • Ath...
  • Taken for 1 to 6 months
  • December 22, 2019

For Acne "I decided to try Tri-Sprintec after a friend recommended it to me, she said it cleared her acne up miraculously. I started this pill a month ago, and I have always had moderate-severe acne (it used to be worse but gradually got better, never fully went away). This pill made me have acne as bad as I had freshman year. It was so bad back then, and I have been absolutely miserable the entire time on this pill. Not only have my emotions been on overdrive, but I never want to leave my house. The pimples are large and everywhere on my face, even in places I rarely break out. Please do not try this pill, there are so many others you could take."

1 / 10
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12 Report
  • Anonymous
  • Taken for 2 to 5 years
  • September 17, 2019

For Birth Control "The first year of being on Tri-Sprintec, I did great. The second year has been rough. Bad anxiety, depression, and I'm just so freaking tired all the time, some days it takes everything I can do to just make it through an 8-hour shift and make it back to my bed. I've always been a very energetic person until this past year. I also haven't had a sex drive in forever, it seems like. And these mood swings, I can't even deal with. I've really been struggling the past year. Never really thought that it was the birth control doing all these crazy things to me."

3 / 10
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12 Report
  • WAa...
  • September 9, 2015

For Abnormal Uterine Bleeding "It's effective in the sense that it has done its job well, it prevented pregnancy, but I absolutely hate it. I switched over from Tricyclen due to its cost, but honestly, I'm planning on switching back. Severe cramps, headaches, and mood swings galore. The worst part of it all? I have been in my period for THREE WEEKS. It's ridiculous, I've never had issues with any other birth control. My regular period usually lasted 4 days maximum, compare that to constant bleeding for almost a month now. No thanks. Do not recommend this for anyone."

3 / 10
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17 Report
  • JC6...
  • Taken for 5 to 10 years
  • May 19, 2016

For Birth Control "I have been on this medication for over 9 years, and it works great for me. My periods are way lighter, and the pain is much more manageable. It causes no mood swings or weight gain for me. Overall, it works great and is very affordable; my insurance covers all of it, but even without insurance, it's only $9/month."

10 / 10
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16 Report
  • Coo...
  • March 13, 2019

For Birth Control "Increased depression and headaches all the time. Got rashes around my face and broke out really bad. Anxiety and mood swings off the roof. Still have cramps and gained so much weight. No sex drive whatsoever and feel nausea all the time."

1 / 10
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12 Report
  • Anonymous
  • April 16, 2010

"I haven't necessarily experienced any adverse physical changes since I started taking this pill. No weight gain, no change in acne, my breasts are still the same size... However, I have transformed into a complete grouch. Although no one seems to notice, other than myself, I have been an emotional wreck. One minute I'm ecstatic, the next minute I'm tempted to rip my boyfriend's head off. I don't recommend this pill."

6 / 10
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23 Report
  • Anonymous
  • November 23, 2015

For Abnormal Uterine Bleeding "I just finished my three packs. Horrible to say the least, but does its job of avoiding pregnancy. If I don't eat before taking the pill, I'm nauseous and vomiting for the next three days. The first month, my period was on time and regular. The second month, I had two periods and would bleed after sex. And this third month has been pretty much continuous bleeding to the point I don't have sex with my boyfriend at all. My periods used to be pretty light and last 4-5 days. Now they're extremely light to the point I hardly have to use a panty liner, and I mostly bleed when I use the bathroom, but it's all day, every day. I'm also moody, cranky, and tired all the time. I'm so done with this birth control and am changing. Do not recommend to anyone."

1 / 10
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16 Report
  • Anonymous
  • March 8, 2010

For Birth Control "I started taking this pill two months before I was supposed to get married. I've never been on birth control before this. It made my boobs enormous, but it also made me into a psycho. This pill has made me very emotional."

5 / 10
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23 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.