Spravato User Reviews & Ratings

• Anonymous
• Taken for 1 to 6 months
• May 9, 2023

For Depression "I have had MDD for years. I started to suffer from depression as an adolescent, probably due to my environment and situations I had been exposed to. Anyway, I have been on just about every SSRI, SNRI, and also antipsychotics and benzos for most of my life. Currently on Trintellix. I have had four Spravato treatments so far. The first treatment was horrible. I relived traumatic experiences in my mind, and the physical effects were almost unbearable. I had such a frightening experience that the doctor was hesitant to have me come back. I am desperate, so we decided to have my spouse sit with me to help keep me in a positive state. This helped. However, I felt hungover the next day and couldn't think clearly. Next treatments only improved slightly, still very uncomfortable, I couldn't wait for the treatments to be done. On the eves of treatments, I had very restless legs and had a panicky feeling. It's been two weeks, and I don't feel any better. In fact, I feel a little worse."

• And...
• Taken for less than 1 month
• April 29, 2023

For Depression "My first treatment was actually exceptionally frightening. When it appeared to peak, I could not move and felt frozen. A very low, soft, short mumble of a couple of words when asked a question. Lips barely moved. Very, very dark and distorted visual when eyes are closed. Open eyes, very difficult to see, and also quite dark. Felt very, very trapped. Wasn't sure if I was dying. Remained highish for several hours after. Also, the next 2 days had negative side effects, which a friend also observed. Never again!"

• Lin...
• Taken for less than 1 month
• January 15, 2023

For Depression "No benefit whatsoever except emptying my wallet by almost $1,000 for 3 treatments over a 2 week period. The nose spray tasted terrible and made me feel 'spaced out'."

• Lrf...
• Taken for 1 to 6 months
• November 15, 2022

For Major Depressive Disorder "Spravato is like the Great Value version of the IV ketamine. I completed the induction period after being on ket for a year. By the end of the induction period, I was suicidal 95% of the time, my BP rose from 100-120/60-80 to 160/100. I received no relief whatsoever from this drug. I’m going back to IV ket, which dramatically helped my depression, severe anxiety, chronic pain, inflammatory numbers, and migraines, and paying $150-500 a session … but that’s how much better ket is."

• Tra...
• Taken for 1 to 6 months
• October 6, 2022

For Major Depressive Disorder "Spravato has done absolutely nothing for me. I’ve become worse than when I started, and I didn’t think that was possible. I am trying very hard not to commit suicide."

• Mer...
• Taken for less than 1 month
• October 5, 2022

For Major Depressive Disorder "I was diagnosed with MDD before 23 years. Since then, I have used several antidepressants. I started Spravato sessions before 6 months. My Dr. recommended 8 sessions (two 28mg doses on each session). I stopped the medication after the 5th session as the medication didn't work at all (ZERO benefit), and my Dr. has agreed with this."

• Car...
• Taken for less than 1 month
• September 5, 2022

For Depression "Spravato was recommended by my psychiatric nurse practitioner for MDD because I have struggled for more than 30 years. I was well informed of the side effects, but no one reported that anything like what I experienced. I think it’s important for anyone who is considering using Spravato to hear about as many different experiences as possible. While most experiences are positive, mine was not. After I administered the second dose, about 10 minutes or so, I began to feel like I was falling, spinning, and losing my mind, completely out of control. I sat there for almost 4 hours, absolutely terrified. Terrified that I would never feel “normal” again, that I would die, I would lose everything that I cared about. I cried in fear and begged the person who gave me the medicine to make it stop. I begged her to tell me that it would stop and that I would feel normal again. I’m still traumatized by the experience and feel like some of the effects are still happening 3 months later."

• Des...
• Taken for less than 1 month
• July 4, 2022

For Major Depressive Disorder "Spravato ended up making me have suicidal thoughts, and I think maybe go into a psychosis or something... I took it for a month. Twice in one week, 34 mg, and then the rest ones were 84 mg once a week. You take it like a nasal spray, and it burns a lot. I just couldn’t move and felt drunk, like mucked up, seeing tracers for about 45 minutes maybe. I didn’t like how I couldn’t move. I was completely numb, it helps pain for that time. But when it wore off, I was still numb mentally. I would get angry when it wore off. It just has to be known, it made me worse. They told me it was impossible to feel worse, which is so stupid. I also have PTSD, social anxiety, and generalized. Spravato made me take a lot of steps back. I had worked so hard to the point to where I was, and it tore it all down. Now I am a lot better and building it back up. But I just still don’t feel 100%. I hope I do. It made me aggressive, I wanted to fight people and harm myself. I used to be addicted to self-harming."

• Din...
• Taken for 1 to 6 months
• May 16, 2022

For Major Depressive Disorder "I have been using Spravato for about 4 months now, and I'm on the highest dose, and I have to say that I am actually getting worse to the point I don't think I'm going to use it anymore. Right now, at this moment, writing this, I'm in the most depressed state of mind I've ever been in. I'm so, so tired of hurting. Nothing but darkness follows and overshadows me. I just can't take feeling the way that I'm feeling. I've tried many medications, TMS, Spravato, and nothing has worked. I want to try ECT, but I can't find anyone to take my insurance. I can't eat, I can't sleep, I haven't bathed in over a year, and my hair is falling out. Plus, I have a lot of physical pain because of an autoimmune disease, I can't find anyone to prescribe me pain meds, so I'm just one big ball of pain. I was hoping Spravato would have worked, but it hasn't."

• Alb...
• Taken for 1 to 6 months
• March 7, 2022

For Depression "8 treatments at 28 mg, last two treatments felt terrible during and 3 days after, can't sleep and feel sick. Went up to 54 mg, sickly past 4 days, can't sleep. This is horrible medicine."

• Ril...
• Taken for 1 to 6 months
• October 4, 2021

For Depression "I started taking Spravato in September 2019. I was hoping it would help with depression, bipolar, and PTSD. I completely changed into another person. I went into major psychosis and ended up in the psych ward five times from the end of December to mid-February. It was horrific and terrifying. I have lingering psychosis, and it’s been two years. I scared the shot out of my family, and there isn’t a day that goes by that it doesn’t scare me that this feeling will never go away. I also had gotten the flu really bad when I was hospitalized and had delusions I could write a book about. I would say not to take it, but everyone is different. Has anyone else had a scary reaction that has lasted two years? Has anyone else gone into major psychosis? (I felt I was gone a million years and saw Jesus and God and aliens, I also believed the world was gone and everyone was dead.)"

• Owl...
• Taken for 1 to 6 months
• June 9, 2021

For Major Depressive Disorder "I did Spravato for six weeks, and it had zero effect on my depression, but did have several negative side effects. I became very aggressive and hostile. The actual process of taking the drug was a miserable experience. The taste was horrible and made me horribly nauseated. The entire experience was not worth it. Add to that, I'm now fighting with the pharmacy that supplied the drug. I qualified for Janssen's assistance, and my portion should have been $10, but Alliance RX/Walgreens is billing me $1000."

• Vro...
• Taken for less than 1 month
• April 1, 2021

For Major Depressive Disorder "I've had 3 sessions now, 2 sessions with 2 doses and 3rd session with 3 doses. After each time, I go home and crawl into bed for the rest of the day. The following day, I'm in a major depression funk. I've asked my doc administering and my psychiatrist, and they say keep going. I'm going to give it 1 more try, but will not continue if a major depression spell occurs the day after again."

• Cat...
• Taken for 1 to 6 months
• August 11, 2020

For Depression "I have bipolar, untreatable depression, BPD. I have done esketamine as both IV and Spravato. Spravato is a waste of time and money. After going through the initial 8-week transition, I was in for Spravato almost every other week, where I was in for IV once a month to as long as every 6 weeks. The side effects were horrible: headache, exhaustion for a day or two, and not knowing where I was. This drug was barely vetted by the FDA, with only 80 test subjects in their group. IV ketamine has years of use and they know it works, but because there is zero money to be made, they will never approve it, so our insurance will pay for it."

• Jan...
• Taken for less than 1 month
• June 6, 2020

For Depression "On Spravato, I felt like I was going to die. It took 4 minutes to kick in. I couldn’t feel my face, couldn’t speak, couldn’t breathe, the room was spinning, music felt far away even though I had headphones in. I heard the ocean. I was sweating, felt like I was sinking, mind racing, nauseous. I felt like I was strapped to a Ferris wheel that wouldn’t stop spinning or falling really fast. I was crying and sweating, 22 minutes in I had a ringing in my ear. It gave me a headache. I couldn’t hear my music anymore, that scared me. I couldn’t move. I was crying for my mom. It was really scary. I don’t feel 100% back to normal today (appointment was yesterday). I feel lethargic, spacey, with no appetite. I feel sad and disappointed that this didn’t work. This was literally the last thing to try treatment-wise. I have to go back to doing TMS every day. Please don’t try this unless it’s your last resort."

• Bal...
• Taken for 1 to 6 months
• January 19, 2020

For Depression "After being on 6 different antidepressants and doing 6 weeks of TMS with no relief from my depression, I was prescribed Spravato. I completed 4 weeks of treatments of 84 mg 2 times per week, 4 weeks of treatments one time per week, and one treatment every other week. I have had no relief from my depression. I feel like the effectiveness of this drug was overhyped. It was expensive and time-consuming and very disappointing to have no results."

• Sti...
• Taken for 1 to 6 months
• September 24, 2019

For Depression "Have been on Spravato for over a month now and developing headaches. My anxiety level is through the roof. Still sad but not crying. Going in for assessment tomorrow."

• Anonymous
• August 27, 2019

For Depression "I posted my experience earlier, and now I have done a total of 10 treatments of the nasal spray Spravato: 2 at 56 mg and the rest at 84 mg. After session 6, I started to feel a little lighter and less depressed, but this lasted very shortly. The treatments after that did nothing for me. They are very intense, and you get awful disassociation, dizziness, numbness. It's a complete out-of-body experience. For me, the feelings were very bothersome, and after I would leave, I was done for the day. I couldn’t do anything, just lay around. I guess if it worked for me, I would have sucked it up and continued even though the side effects were so bothersome. Unfortunately for me, this didn’t work, and it cost me a fortune. Personally, I wouldn’t advise others to do this until there is more research about it. It is still very new, and doctors are still learning by experimenting on us! However, the one done by IV is not as new. I will continue to fight the fight, but will never do Spravato again."

• Anonymous
• Taken for less than 1 month
• January 5, 2023

For Depression "I felt okay the first 2 times on a lower dose. I felt like I would not want a higher dose. I felt a bit out of it and anxious, but not terribly so. On the third visit, I was encouraged to take the next higher dose. I was assured by staff they would be able to help and support if anything was too much. Well, after 3 or 4 minutes following the final spray, I felt an incredible intensity of pure, deathly fear rising higher and higher. I tried to listen to meditation and do some breathing techniques. NOTHING made me feel better. I just kept feeling worse. I could not remember who I was or how to move my body and felt like I had severe dementia for a while. I forgot my life and what my phone was, and I was afraid I would never come back to who I was. Then I just felt like I would die. My heart felt like it would explode. I literally felt I needed medical help. The staff person stayed for a little while, then left me. Even when I told them I needed help and clearly was in distress... Never again."

• Ric...
• Taken for less than 1 month
• February 22, 2022

For Major Depressive Disorder "I am using this for PTSD. The drug experience is horrible. After I spray it in my nose and it begins to take effect, I pray it will end. The feeling is so horrible. I want to throw up, I can't physically move, I can't assess where I am, I can't 'sense' anything, but I am aware of how bad I feel and pray it ends. For 24 hours after each treatment, I am a worthless dish rag. I feel my brain will never come back. No ability to think and want to vomit. I can't take many drugs. I have severe reactions. I opted to try Spravato because it is not every day. You won't want a soul near you when under the effects in the office. I feel I am in prison. Trapped. Can't scream. Buried alive with no help. It is a bad trip. If it treats PTSD, it is worth more than the nightmare side effects, that is the only reason I tried it. I have had allergic reactions to everything ever given to me. I am not allergic to Spravato. I just am terrified of how it makes me feel. I dread treatment."

• Sti...
• Taken for 1 to 6 months
• August 3, 2021

For Depression "Part of a clinical trial for treatment-resistant depression without any other antidepressants. I have 2 treatments left, and it hasn't worked at all and has made my accompanying anxiety worse!"

• ela...
• Taken for 1 to 6 months
• March 4, 2021

For Depression "I did a full month of treatments - 8 total at the 84 mg dose. I enjoyed the experience, however, it did absolutely nothing to help my depression. I am going to try IV ketamine infusions at some point, as I understand they are more effective for many reasons. I started with Spravato because it only cost $520 total for all 8 visits ($55 copay and $10 for Spravato through the J&J program)."

• Lal...
• September 2, 2020

For Depression "I suffer from depression. I’ve tried different meds, and none have seemed to help. I heard of Spravato and was very excited to know there was a treatment out there that could work. I’ve done 6 sessions of Spravato and have seen no improvement. I have an appointment tomorrow for another treatment. I really don’t like the experience. As you inhale the Spravato, you get the nasty taste. Then you’re in for a ride of feeling like you’re outside your body. Feeling like you’re completely numb. Face, feet, etc. I hate the whole experience. Everyone is different. I hope this works for others that are going to try this. Good luck!"

• Cal...
• Taken for less than 1 month
• September 1, 2020

For Depression "I’ve had 5 Spravato treatments so far for depression. I felt a lightening of my mood after the first three treatments, however, the feeling didn’t last long, maybe 24 hours. I’m hopeful that with continued treatments, I will improve. I don’t have a strong reaction to the medication when it’s administered, just a slight disassociation with time and place that I can easily bring into perspective. The nasal spray dripping down your throat is horrible, and I take Zofran and omeprazole before my appointments to counter. I had 15 ketamine injections a year ago, and they helped a little. I’ve yet to have an infusion. I know that is the gold standard, but I cannot afford it financially."

• Dan...
• Taken for 1 to 6 months
• February 3, 2020

For Depression "When I read about Spravato, I was so excited. I had failed TMS and multiple oral medications, so this new format of spraying something directly into your brain. Initially, I had a great amount of dissociation for the first hour, which gradually dissipated. The day of the treatment, I felt great, but then it seemed to just go away. While on it, I had increased suicidal ideations. I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. But after that, I elected to stop taking Spravato. I think it is very promising, but it is too new to have a history, and I’m done being the guinea pig."