Spravato for Major Depressive Disorder User Reviews

• Sta...
• Taken for 1 to 2 years
• March 31, 2021

"This is an update to a review I wrote 6 months ago. I have now been on Spravato for one year. I have had depression and suicidal thoughts nearly every day for the past 25 years. Except for the last year on Spravato. Every month I see a gradual improvement. The biggest improvement my first six months was the cessation of suicidal ideation. The last six months, not only has my general sadness gone away, but I can now bounce back when things are rough. I still have healing to do, but none of it would be possible without Spravato."

• San...
• Taken for 1 to 6 months
• March 17, 2021

"I can only speak about my own experience. The medicine does the work it sets out to do. I am a person struggling with CPTSD and depression. Spravato has helped significantly reduce suicidal ideation, reduce depression, and overall increase my well-being. The post-nasal drip is similar to that of any allergy nasal spray. The onset lasts approximately two hours in which I meditate, listen to audiobooks, and practice mindfulness. This is the largest breakthrough in psychiatric medication since 1987. I am not paid for this review nor am I affiliated with the pharma industry in any way."

• Anonymous
• Taken for 1 to 2 years
• October 6, 2020

"The Spravato nasal spray literally saved my life, and I did it for a year straight. I did end up overdosing by taking it with tramadol that I was given for pain from my third hip surgery that I had no idea would interact with. I only got to the 2nd spray before I had to spray the other into the trash to act like I used it because they refused to believe I had overdosed. I stopped going back for that unless for emergencies. It was perfectly fine for a year, and I felt as if I could live. I used to do acid when I was younger, so tripping never scared me. It is a huge experience for anyone wanting to try it, but if you're at wits end, I'd say go for it. It worked for me. Just remember that tramadol is a MAJOR interaction, and both kratom and klonopin/xanax will make the Spravato less effective when using it. Hope this helps for anyone wanting to try."

• Gen...
• Taken for 1 to 6 months
• December 15, 2020

"I’ve dealt with depression for over 40 years and have been on most medications. This is the first time I’ve felt on the path to the true me, free of the clouds. This has literally saved my life. While I chose MDD as the condition, I am more accurately Treatment-Resistant Depression."

• Lee...
• Taken for 6 months to 1 year
• January 4, 2021

"My first treatment was February 7, 2020, and my life has been completely changed thanks to this medication. For one thing, it has given me hope that there are new treatments to fight depression. The best thing is it is working! I no longer stay in bed all the time. I have more energy, and I enjoy living life again. As far as the treatments themselves, I get a feeling of euphoria for the first 40 minutes. My face, lips, and nose have a very numb feeling which goes away within about 2 hours. Some days after my treatment I feel fatigued, and some days I have a good amount of energy. For me, watching funny videos/comedians/movies on my iPad helps me not to dwell on the results of my treatment when coming down from the 'high'. Personally, this medication is a blessing and it has given me my life back."

• TMW...
• Taken for less than 1 month
• March 25, 2024

"I have struggled with depression and anxiety for years. I have tried many different meds. In 2019, I lost my middle son. In 2021, I lost my youngest son, and in January 2023, I lost my partner. I ended up in this hopeless, anxiety-ridden depressive state along with PTSD from having to drive my son's car after he had been in there for 2 days after he passed away. I thought about suicide 24/7. I am on week 3 of the treatment. I am taking the 84 mg 2x per week. All I can say is I couldn't remember what it felt like to not be in this brutal pain, and this is the first time in such a long time that I feel hopeful that something will finally work. I am feeling better every day. This is not a cure-all, and I went into this treatment recognizing that. I still have a lot of work to do and therapy ahead of me, but this has been a game-changer so far."

• Dog...
• Taken for 1 to 6 months
• June 22, 2021

"Dx: MDD, GAD, C-PTSD Current Medication Regimen: Prozac 60mg, Atarax 50mg, Seroquel 100mg, Prazosin 2mg, Trazodone 50mg, and Spravato 56mg weekly. 4-MONTH UPDATE: Less suicidal ideation, higher moods, increased energy, and increased motivation. While I do have mild/moderate symptoms from time to time, I can finally go out and do stuff for once in my life. This medication regimen is a game changer for me. If you've suffered from severe depression for years, this medication may just change your life."

• Mak...
• Taken for 1 to 6 months
• December 20, 2020

"Suicidal depression has plagued me since before I could even conceive of it — probably very much like gender. A panoply of medicines, always with Cylert or Ritalin, provided a substantial modicum of relief for decades. However, consciousness continued to be unbearably painful, and a craving for self-annihilation became my default. One week of the higher-dose treatment (3 containers) remains, and, while I am not elated, the constant suicide hunger is gone. I don’t yet know if it facilitates pleasure, but it does stop the death default."

• Sei...
• Taken for less than 1 month
• February 20, 2025

"I had my 6th treatment today. I have struggled with depression for 32 years. Meds have helped, but I was kind of out of options. Spravato has been amazing for me so far. I was doing quite well going into treatment, but my brain just hurt, was still slow to think, and joy was stagnant. My experience of Spravato has been a spiritual experience. During treatment, my prayer is focused, and my mind recalls so many good things in my life, like the things and people that matter the most are front and center. I have listened to some music, and other times am just quiet. I am fully present, but at the same time, my brain is clear and fixated on whatever I am thinking of. Speech, words in music just seem to slow down, I can hear everything perfectly. This lasts for about 45 minutes. My brain pain and depression are gone. I can think more clearly, my sense of humor is fully back. Small things don't seem to upset me quite as much. This medication has helped me, and I am encouraged."

• Fir...
• Taken for less than 1 month
• November 23, 2020

"Had my first Spravato treatment today. The high feeling lasted about 45 minutes. It felt like my legs were separated from my body. I felt really happy. Coming down was not very fun. I started to feel sad again. I’m not giving up though. Going to keep going."

• SLA...
• Taken for 6 months to 1 year
• November 5, 2023

"I've been fighting MDD, TRD, and anxiety for almost 40 years (I'm almost 60). Spravato is the ONLY thing that has helped. Side effects for me last about 2 hours. I noticed an improvement after the third or fourth treatment. It's been a complete game changer for me."

• Jay...
• Taken for 1 to 6 months
• July 15, 2024

"I have had treatment-resistant depression for 31 years. My doctor suggested Spravato. I had thought about suicide many times but never had a plan. Now, I was scared. Even though I started Spravato, I made a plan to kill myself. I didn't want to live anymore. I continued with the treatments faithfully. 84 mg for 16 total treatments. Around the 10th treatment, the thought of killing myself lessened more and more. Spravato saved my life. I don’t know how, but it did. There is hope. The suicidal thoughts have lessened. Now I am coming out of my isolation, negative thoughts, pessimism, and everything that depression brings with it. For those of you suffering from treatment-resistant depression, please ask your doctor about Spravato. If it helped me, it can help you. There is help."

• San...
• Taken for 1 to 6 months
• February 19, 2022

"11 weeks in and I am happy, thinking positively, seeing life brighter! I’m driving, being social, etc. Been struggling for 25 years. Started feeling good at about 6 weeks but even better now. Just so you know, every time you have a treatment, the experience is different. So if for some reason something is unpleasant, it doesn’t mean it always will be. Try to relax, bring water, hard candy, or cough drops for the short time the taste is bad in your throat, and I recommend headphones with music you like. You should be able to bring a pillow and small throw to cover up with. All this can make you more comfortable. I’ve never gotten sick or had any bad effects afterward. Spravato is helping me to be myself prior to my depression."

• Dog...
• Taken for 1 to 6 months
• April 29, 2021

"I'm currently in week 11 of treatment with esketamine 56 mg once a week. I feel that it started to work around weeks 6-8. Less suicidal ideation, more energy, improved mood, etc. I have had some minor bladder problems, such as an urgent need to urinate. However, the benefits far outweigh the side effects. I'm hoping to start on 84 mg soon. Diagnosed with MDD, PTSD, and GAD."

• Mar...
• Taken for 6 months to 1 year
• April 26, 2021

"September 24, 2020, started Spravato after dealing with self-hate, suicidal thoughts, depression, and rage for over 35 years. Being admitted to a mental facility and being prescribed several different medications which worsened the idea of suicide, I felt this was the last option. I am taking 3 sprays per month, and it has helped me a great deal. I take a Zofran shot before treatment and also take 2 Phenergan when I wake up the morning of the treatment to help with nausea, however, I still vomit during the session. I have tried an empty stomach, and that doesn't help either. I am very sensitive to smells now as well. The smell of the doctor's office now makes me sick to my stomach. Other than the side effects, I do think it is a good drug for me. I do seem to lose my train of thought, and if speaking, sometimes I cannot complete sentences and cannot think of words. I am a bit skeptical of the long-term affect of using this drug."

• Kat...
• Taken for 1 to 6 months
• June 1, 2022

"I started using ketamine in November of 2021. I had my doubts that it would work because I have tried so many other medications throughout the years, and I suffer from major depressive disorder. After the first 3 weeks at two treatments per week, I started feeling better. Currently, I have been taking my second round of Spravato. My suicidal thoughts are gone, my depressive state is incredibly unreal. No depression, no anxiety, and I just can't believe this drug works as well as it does. If you suffer from depression, anxiety, and it also helped my chronic pain from nerve damage, my advice to you is to try Spravato. It's amazing! I have never, ever felt as mentally good as I do now with the help of Spravato. It's a game changer."

• Vro...
• Taken for less than 1 month
• April 1, 2021

"I've had 3 sessions now, 2 sessions with 2 doses and 3rd session with 3 doses. After each time, I go home and crawl into bed for the rest of the day. The following day, I'm in a major depression funk. I've asked my doc administering and my psychiatrist, and they say keep going. I'm going to give it 1 more try, but will not continue if a major depression spell occurs the day after again."

• sea...
• Taken for 5 to 10 years
• October 23, 2023

"I've had nothing but a positive experience with Spravato. The key to getting the most effective treatment is to just relax and avoid any distractions, such as your cell phone. Close your eyes, lay back, and let the drug do its work. Then you will get the best experience. If you are distracted, it will not work as well as it can. I've been on Spravato for 6 years, and I can't say enough good things about it. It gives me a sense of normalcy if only for a while. Just relax and let it do its magic."

• Cir...
• Taken for 6 months to 1 year
• November 2, 2023

"I've been on Spravato for 6 months and it got me through a period I'm not sure I could have endured otherwise. I highly recommend it. I started EMDR therapy last month, and EMDR + Spravato has been so incredible. It's like I started all over again. Definitely recommend, but I super recommend it with EMDR if you can swing it. They're like two sides of the same coin. My brain is quiet some days, and that feels like a miracle."

• Sar...
• Taken for 1 to 6 months
• April 4, 2025

"I've been taking Spravato now for approximately 16 months. I have MDD and panic disorder, all starting about 7 years after being diagnosed with chronic pain from spinal stenosis, and two failed lumbar fusions. I had been on traditional SSRI therapy for almost 20 years without much improvement. The depression actually started exacerbating, as well as the panic attacks. I started on Spravato in 2024 with the lowest dose (56 mg) bi-weekly, then quickly moved up to the highest dose (84 mg) once a week. I am currently transitioning to once every other week. When first starting off with the treatments, I had a lot of issues with anxiety/panic from the drug's known side effect of rapid heart rate. I thought maybe that this was not the drug treatment for me. I was put on a low-dose beta blocker, which has worked wonders. To tackle the nausea, I was instructed to buy ginger soft chews. This took care of the nausea. The depression is now finally in remission."

• Bob...
• Taken for 1 to 2 years
• April 25, 2021

"Been on Spravato for over a year. Still have been on a regimen of 84 mg twice a week. It has not given me really any adverse effects, light equilibrium issues when on it. When I first started, it was very helpful, but weaning down to anything less than twice a week hasn't been able to work for me. It's helpful for a few days and goes away, wouldn't call it a miracle drug. But it's very helpful compared to the countless other medications I've been on. Definitely bring some Listerine patches or strong mints to help with the nausea/bad taste. Have MDD, PTSD, and anxiety disorder. Spravato is an effective medication, but with the caveat that weaning down really makes the depression kick in. Advice: make a nice playlist of music and try to relax."

• Lrf...
• Taken for 1 to 6 months
• November 15, 2022

"Spravato is like the Great Value version of the IV ketamine. I completed the induction period after being on ket for a year. By the end of the induction period, I was suicidal 95% of the time, my BP rose from 100-120/60-80 to 160/100. I received no relief whatsoever from this drug. I’m going back to IV ket, which dramatically helped my depression, severe anxiety, chronic pain, inflammatory numbers, and migraines, and paying $150-500 a session … but that’s how much better ket is."

• for...
• Taken for less than 1 month
• February 20, 2022

"For years (actually) decades, I’ve fought the beast… have tried it all and still fighting. I finally agreed to try Spravato. I thought it would be like a chemical ECT. I hesitate to say this and jinx the results, which have been stunning. I’m only in my third week of treatment, but the impact has been dramatic. Where I could barely get out of bed in the morning, I’m now up and moving. No negative side effects. No apparent issues with other meds I take. I only hope this impact will be long-lasting…"

• Chr...
• Taken for 1 to 6 months
• July 19, 2022

"I have struggled with TRD most of my life. I did not respond well to other medications or therapies. My first treatment with Spravato at 56 was amazing. My second at 84 mg was intense, unpleasant, and also very beneficial in helping me address an issue. During treatment, my service dog died, and the grief was overwhelming. I went in crying and came out better able to cope. This is a game changer for me. The dissociative aspects help me to get out of my own way and address issues. I’m going to continue taking this weekly because each time it feels I’m dropping some sad, heavy weights and leaving them behind."

• cha...
• October 29, 2024

"I've been battling with MDD and TRD for almost 30 years. I'm 53 years old now. I used Spravato, well, I'm still using it under supervision. Today, I had a session with my doctor. She said that because it is working the day of use, I should continue with it. Frankly, I don't see much difference in my depression. I still feel depressed. I'm not sure if it has to do with Spravato, if anything, it should help me with lifting my mood. I'm desperate, and I wish there were a miracle drug I could take. Spravato gives me a high, and I feel good for a few hours, but then comes the sadness."