Xtandi and Fatigue: What Users Say

• Ray...
• Taken for 1 to 6 months
• May 25, 2022

For Prostate Cancer "My 88-year-old dad was put on Xtandi combined with hormone shots for prostate cancer (returned after 10-year remission). I questioned this since his PSA dropped a lot after just one injection. The doctor felt it was needed to ensure the cancer didn't metastasize. He has been on Xtandi for about 5 months, and I've seen an alarming decline in his overall health. He's gotten so weak that he fell yesterday and couldn't even get himself up. He's having bad back pain, lethargy, sleeping long hours, general malaise/unconcern, loss of appetite, moving at a very slow pace, and now falling. We're taking him off Xtandi. While it's an antiandrogen, it seems to work like chemotherapy! It 'might' be effective (can't really say), but I don't think it's worth the chance he's taking. I just pray all the harm (even more than listed here) this drug has done in this short time will reverse. I'm scared, given another review here, though, that the damage will be permanent. Time will tell... only God can heal."

• Dot...
• Taken for less than 1 month
• June 1, 2022

For Prostate Cancer "My elderly dad was on this awful drug for a month. Side effects were very severe and debilitating. Has gone from walking around the house on his own to now using a walker. Weight loss was very sudden and huge! He’s mentally very sharp and is a doctor himself. Would not recommend this drug to anyone!!"

• Ed ...
• Taken for 1 to 6 months
• April 25, 2025

For Prostate Cancer "85 years old. Prostate removed 2016. Long remission but returned in 2024. PSA level over 1000. Pain in lower back interfered with sleep. Two days after starting Xtandi, pain completely gone. April 2025 PSA level 0.35. Testosterone level was 11. Brain fog and fatigue most noticeable side effects thus far. Can tolerate both. Lift weights twice a week to offset fatigue and weakness. Also to put mild stress on affected bones. Hope can continue this way indefinitely. Great medication for me."

• Dav...
• December 23, 2016

For Prostate Cancer "Found Xtandi to be a waste of time. Instead of aiding or lowering my PSA, it raised it to 90 from about 15 when starting it. There was severe fatigue and dizziness. Not satisfied."