Replens and Cramps: What Users Say

• Ech...
• Taken for 1 to 6 months
• June 8, 2020

For Vaginal Dryness "I started using Replens as my gyno suggested for vaginal dryness/atrophy in March 2020. No negative reaction at first, with the exception of clear discharge. It is now June 2020, and I noticed I've been experiencing slight cramping like I'm going to get a period. I'm in my 60s and post-menopausal. Yesterday, I noticed a brownish discharge and still experiencing slight cramping. Will stop using Replens product immediately! I think further research and investigation into the product should be put in place, pronto. Too many women are having too many strange and unexplained reactions to this product. FDA should be alerted - NOW!"

• mar...
• Taken for less than 1 month
• September 20, 2020

For Vaginal Dryness "AVOID. Severe uterine cramping after the second dosage (3 days after the first one) with big black lumps and brown blood a few hours later, which is now fresh red blood with big lumps in it. This has been going on for 2 days, I hope it will stop, or I'll be going to the doctor next. I am peri-menopausal and dry after ovulation, hence the recommended cream. I've never had any spotting or bleeding between periods, this is a reaction to the cream. What have they put in it to cause such a severe reaction?"

• Jaz...
• Taken for less than 1 month
• October 4, 2020

For Vaginal Dryness "I have used Replens 3 times. I was crampy the first time. Felt like an oncoming UTI after the second insert. Then the white wet tissue discharge after the third time. Done... was not cheap, so a waste. Too many ladies seem to be having the same symptoms. Like others, wish I had read these reviews! Just don’t..."

• Ann...
• Taken for less than 1 month
• October 17, 2021

For Vaginal Dryness "Be very wary when using this product. As per many of the ladies on this forum, I have experienced a really bad reaction to this medication and wish I had seen these reviews beforehand. I was diagnosed with severe vaginal atrophy in July, and the first round of HRT has not worked yet, nor estriol pessaries or cream from the Gyn. The GP recommended Replens. Total disaster - horrible burning and pain while urinating. Already had the start of a UTI, which compounded the situation. Inside looked as bad as it felt. Soreness, itching, and pain with swollen labia, internal AND external. I have also had the white clumpy residue. I wonder if that is related to the cramping. I will never use this again and will need to find out how to report these issues. If this product helps someone, then that’s great, but the majority of us are in worse shape from having tried this. If I could rate this 0 or a minus rating, I would. This product should be pulled from circulation."

• mou...
• Taken for 1 to 6 months
• April 12, 2020

For Vaginal Dryness "I used Replens for 2 months, and initially had no side effects from it, used it for postmenopausal vaginal dryness, recommended by my gyno. Last week, I started to feel like I was going to have a period start, after peeing, I wiped and saw clear discharge with a brown tinge to it. I have to say prior to this, for about 2 weeks, I was noticing a white type of discharge, no smell, consistency of wet toilet paper, which is what I thought it was at first. After reading these reviews and many others, I now know it was not that. I have mild cramping like that of a period and am still spotting. Currently, it does seem to be subsiding, at least I hope so. Stopped using about 5 days ago, and really, I should have stopped using it when the white stuff appeared. I knew it was the Replens that made all this happen. Would not recommend this stuff to anyone."

• Lin...
• Taken for less than 1 month
• October 17, 2020

For Vaginal Dryness "So, first time buying Replens and first time using this. I too wished I had read reviews. Not even time for my period for two more weeks, and I’m cramping like a period is fixing to start. I had string-like discharge to now white, rubbery-like chunks and balls. Yuck! Bad decision. Product isn’t what I had expected at all. Won’t be using again. I tried washing everything out of me, but I’m still steadily cramping."

• Anonymous
• Taken for less than 1 month
• July 2, 2021

For Vaginal Dryness "Omg, I wished I had read the reviews on here! I’ve recently used Replens MD cream and didn’t think it was connected, but now after reading the reviews! The first time I used this, I contracted a kidney infection. Two weeks later, a uterus infection! I’m 54, post-menopausal, tried the cream for dryness, and all I got was bad abdominal cramping, a swollen abdomen, and bleeding! I’ve not bled for 8 years. These side effects need to be on the leaflet inside!"

• Lma...
• Taken for less than 1 month
• July 31, 2020

For Vaginal Dryness "I tried this product, Replens, for vag dryness, trying to stay away from hormones. I used it before I went to bed, the next day I felt cramping, no bleeding or discharge yet. I now wish I saw these postings before I bought the product. I will not use it again."

• Lin...
• Taken for less than 1 month
• February 28, 2023

For Vaginal Dryness "I am 53 and have vaginal dryness. I bought this...started it on a Friday...every day I started feeling worse. Sunday I had abdominal cramping, bloating, and feeling like I had a UTI. It is now Tuesday, and I am just starting to feel a little better...but now I am a little itchy. UGH! I never thought buying this would lead to all of this."

• Tut...
• Taken for less than 1 month
• January 6, 2023

For Vaginal Dryness "I started using it to combat dryness. Took one dose, after a day, I started seeing the wet tissue-like discharge, and then the cramping started! I have an IUD, so I assumed it was that causing the cramping, but I was wrong. A few hours after the cramping, bleeding started. It was a dark-ish color and was very scary. I haven’t bled in over a year, so what was bleeding? I had to see my doctor, who was also confused as to why that happened. Couldn’t even have sex, which was the whole point! Possibly this medicine."

• Ano...
• Taken for less than 1 month
• April 3, 2023

For Vaginal Dryness "I used 4 applications of Replens and had a bit of blood on the applicator after the second time, a spot of blood after the third, and a small bit of blood when I wiped after the fourth. I also had 2 1/2 days of abdominal cramping on and off. I had a complete total hysterectomy 11 years ago. I phoned the Replens company on the box and reported the issue, and funny enough, they said they never had any complaints. They told me to stop it immediately and the complaint would be looked at. I am also going to report it to the FDA. Everyone should report it. Hope I haven’t damaged myself!"

• Mg6...
• Taken for less than 1 month
• June 19, 2021

For Vaginal Dryness "I too wish I had read these posts! I started taking Replens on the advice of my GP at the same time I was taking antibiotics for a UTI. Two days after I finished the antibiotics, I used another dose of Replens (every 3-day dosage) and felt cramping and bloated. The next day I had vaginal itching. The following day I experienced itching and burning, so I thought it was a yeast infection due to antibiotic use (even though I took probiotics). So I used an over-the-counter yeast medication. But I'm still having the cramping, also the brown discharge and now white discharge. I will see my MD if it doesn’t go away. I had taken 4 doses of Replens."

• Anonymous
• Taken for less than 1 month
• March 27, 2022

For Vaginal Dryness "I have experienced the following: 1st application thought I was getting a UTI; second application pelvic cramping as if I was getting a period, soreness; 3rd application cramping soreness, needing the loo more often (as if I was getting a UTI) and some blood after peeing when I wiped. I had a hysterectomy over 20 years ago, and my Gynae recommended Replens for soreness and dryness. The solution is worse than the problem for me. In fact, if I hadn't been to get a Gynae check 6 weeks previously, I would have worried that something was seriously wrong. Product manufacturers need to warn more openly about all the possible side effects that so many women seem to be experiencing."

• Anonymous
• Taken for less than 1 month
• March 27, 2022

For Vaginal Dryness "I have experienced the following: 1st application thought I was getting a UTI; second application pelvic cramping as if I was getting a period, soreness; 3rd application cramping soreness, needing the loo more often (as if I was getting a UTI) and some blood after peeing when I wiped. I had a hysterectomy over 20 years ago, and my Gynae recommended Replens for soreness and dryness. The solution is worse than the problem for me. In fact, if I hadn't been to get a Gynae check 6 weeks previously, I would have worried that something was seriously wrong. Product manufacturers need to warn more openly about all the possible side effects that so many women seem to be experiencing."

• Nan...
• Taken for less than 1 month
• May 31, 2023

For Vaginal Dryness "I just began using Replens. With first and second days' use, I did not feel cramping, bloody/brown show, etc. Several weeks later, with third use, bingo, I experienced bloating, cramping, blood/brown show. Today, after yesterday's application, I am still bloated and have cramping. I am seventy-one and not on any kind of medicine, so nothing has interfered with the product. I hope all who experienced side effects called the company, they need to know your experience. What's happening isn't right, and they need to know."

• Anonymous
• Taken for less than 1 month
• October 14, 2021

For Vaginal Dryness "Used Replens 6 hours ago, and I'm typing this laying in bed in the fetal position, in tears with the worst cramps I've ever had in my life. It feels like period cramps, but so much worse. The drama of menopause is bad, but I'd much rather deal with that than this, and I wish I had found this forum prior to spending a decent amount of money on this junk."

• Que...
• Taken for less than 1 month
• August 27, 2021

For Vaginal Dryness "Thought I would try because of vag dryness. On second round, noticed thick white/grayish discharge on first use and second, it has increased, it's quite unsettling, but if it's dead cells, omg, how much more. Now feel slight cramping, unsure if it's the product or my cycle. Nothing has changed with the dryness, debating if I should continue use."

• Key...
• Taken for less than 1 month
• July 18, 2022

For Vaginal Dryness "I’m in my late 20s, decided to use this product for more comfort during sex. I only used the product twice. It was the worst decision I could have made. Ever since, I’ve dealt with cramping, thick white discharge, vaginal irritation, and my period has not been the same. Complex cyst first on the left ovary and on my f/u visit, now on the right ovary. This product definitely seems to affect hormones as I had no issues before using it. I’m scared and praying that my body will go back to normal. I would not recommend this product."

• Sue...
• Taken for 1 to 6 months
• March 28, 2022

For Vaginal Dryness "Same experience as the other reviewers. I almost had a heart attack after I wiped and saw lots of thick, rubbery white clumps with what looked like brown, dried blood mixed in. I also got slight cramping after applying each time. I only used this about once a week for two months, and the discharge happened after the second month - or maybe it got cleaned out when I had my period and I never noticed it. I'm going to be looking for another product, as this is not an acceptable option for me anymore!"

• Anonymous
• January 17, 2022

For Vaginal Dryness "I get intense burning from the usage of Replens and bad cramps. My cramps aren't uterine because I had a hysterectomy years ago, so I know these cramps are actually from the burning inside my vagina, which mimics period cramps. These symptoms aren't something someone would expect from a product that is supposed to be helpful. It doesn't work well for my vaginal dryness either. I'm throwing the rest of the box out, which makes me mad because it's way overpriced. I don't trust this product."

• Sar...
• April 3, 2021

For Vaginal Dryness "After inserting the cream last night, I knew straight away something was wrong, started to panic a bit but just went to bed to try and calm down. This morning, I have severe cramps like period pains and a white discharge. I wish I hadn’t bought this, I’m in agony! Will portion help?"

• SSW...
• Taken for 1 to 6 months
• July 3, 2022

For Vaginal Dryness "It felt moisturizing at the beginning, but after a few weeks I got some mild cramps accompanied by a black discharge. I went to see several doctors, and they were all shocked because they found pieces of a black silicone-looking substance. The last one tried to manually remove it. I got a PAP smear, two ultrasounds, and they took samples to check if I have an infection, and they couldn’t find anything. I’m about to get a biopsy and a hysteroscopy just in case. I was so worried until I found all the reviews online. How is it even possible that a product like that is on the market and even the doctors are clueless about it?"

• No ...
• Taken for less than 1 month
• June 11, 2022

For Vaginal Dryness "Used this just once, and it might have relieved some dryness, but 2 days after using, experienced severe cramping, itching, and swelling, and white clumps coming out. Resorted to trying to rinse it out and using my finger to scoop some of the disgusting clumps out. Will never use this product again, remaining tubes now in the bin."

• Mim...
• Taken for less than 1 month
• November 30, 2021

For Vaginal Dryness "It sounds like we are all having similar reactions to this product. I am postmenopausal and a breast cancer survivor, so hormones are not an option. I took Replens at the suggestion of my gynecologist. With the first two doses, I had the brown discharge, then the third dose gave me uterine cramping! I was worried about what was going on. How does this product cause cramping if it is not hormonal? I am glad I found this site, but I am ceasing use of this product! Not a good use of my money and doesn’t seem good for my health!"

• DMA...
• Taken for 1 to 2 years
• June 15, 2023

For Vaginal Dryness "During 10 months of use, I started to experience severe bloating over the past 2 months, some burning, swelling, and just recently cramping on and off. Also, white discharge is more frequent. I too wish I had read these comments sooner. I used it yesterday and will never use it again. The product needs to be improved or taken off the market. I also thought that I had a UTI a while back, and other times, and tested negative with urinalysis and culture each time. I'll continue with external gel HRT."