Dupilumab and Peeling: What Users Say

• Cri...
• Taken for 1 to 6 months
• September 15, 2020

For Eczema "I started this horrible drug, Dupixent, in April 2020 for pruritus nodularis and stopped it 3 weeks ago. It would cause me to sleep round the clock and could get nothing done as I couldn't get anything done. It also caused me to break out with scary eczema all over and caused the skin to peel off my hands and my heels. I had no life. Hope to spend a whole day awake soon. It did stop my severe itching at night, but is now returning. Time will tell. This stuff is bad. Stay away from it!"

• CCH...
• May 3, 2017

For Eczema "I have had eczema for my whole life. I am a woman in my mid-40s. It seems to be mainly stress-related and has been fairly awful the past 10 years. I stopped Kenalog shots about 6 years ago, my eyesight and joints were suffering. The past 6 years have been hell. My allergist helped get me this drug and even worked with the pharm rep to get a coupon for zero co-pay (using commercial insurance). I am thrilled to have had my first 300 dose just a few days ago. Within hours, my skin felt softer. I have read all the studies and it appears you will see max results between 30-45 days, so I will come back and write more. I do see my eczema clearing up -- I am very flaky on my face right now, so that is itchy, but the intense itch seems to have subsided."

• Kan...
• Taken for 1 to 6 months
• January 13, 2019

For Eczema "I’m probably the only person who has had an adverse reaction to Dupixent. Somehow, after starting the treatment, my eczema has worsened, flaring up in places it’s never been before, flaking and even peeling all over my hands. I have seen no change in the amount of itching. I have done 3 injections and do not notice any good results at all. I will stick with it, though, because I still have some hope that this will help clear up my eczema. I'm hoping that because I started it during the cold and dry season, that it doesn’t work as well."

• Kan...
• Taken for 1 to 6 months
• January 13, 2019

For Eczema "I’m probably the only person who has had an adverse reaction to Dupixent. Somehow, after starting the treatment, my eczema has worsened, flaring up in places it’s never been before, flaking and even peeling all over my hands. I have seen no change in the amount of itching. I have done 3 injections and do not notice any good results at all. I will stick with it, though, because I still have some hope that this will help clear up my eczema. I'm hoping that because I started it during the cold and dry season, that it doesn’t work as well."

• Joh...
• Taken for less than 1 month
• October 10, 2017

For Eczema "I've had eczema my whole life, but the past 2 years have been the worst, and I'm 30. It's been life-changing and so debilitating. My dermatologist said I was the worst case she's ever seen after 20 years in dermatology. I mean everywhere, tried to everything, scratching constantly, all night, in meetings, after the shower, I've lost sleep, cried a lot, been miserable. I've been on Dupixent for two weeks, and my skin has never felt so smooth!! Cleared up about 85% of my rashes about 4 days after my first dose. When I sweat, no itch, which is so rare. I don't wake up to dry, flaky skin everywhere. I'm so happy and amazed. I hope it keeps working like this because my quality of life is gonna be so much better. God, this stuff is great!!"

• Joa...
• Taken for 1 to 6 months
• April 9, 2018

For Eczema "Another disappointment as I was told today to go off this medicine. Definitely saw great things happening to my skin until my eyes went crazy, crusting, tearing, swelling, and flaking. I pray they can correct this side effect of the medicine."

• No ...
• Taken for 1 to 6 months
• January 31, 2021

For Eczema "I've had eczema on my legs, feet, and heels. I got the Dupixent injection four months ago, and it cleared up. But recently, I started itching again and starting to see the side effects: peeling, cracking, and dryness of the inner and upper eyelids. Just a few hours ago, my left lower eyelid (above my cheek) started getting loose and soft. My dermatologist told me there would be eye side effects. I've been waking up with my eyelids stuck together and crusty, I have to use a warm compress. From what I read, the main active medicine that clears the eczema is what makes the eyes break out. Not sure how long the side effects will last, it's only my first shot."

• Ele...
• Taken for less than 1 month
• August 21, 2024

For Atopic Dermatitis "I had my first injection a week ago. On the second day, I had chills, weakness, and fever. Breathing problems started. My skin began to peel severely. Discomfort in the heart area. Itching has decreased, and my skin has become firmer. I will add to the review after the next injection."

• Oce...
• August 23, 2022

For Eczema "Age 30 - tried Dupixent for 3 months, 2 shots a month. Was essentially sick the entire time with a stinging, peeling, painful needle-feeling rash, getting rashes in places I never had before, was losing hair by the handful. Did help with body eczema a bit, but not worth the intense pain. I looked and felt like a burn victim. It was sort of a cycle - I would take the shot and be extremely sick for about twelve days, then have 2 somewhat okay days before I had to take the shot again. The only relief I ever felt was near the end of the cycle and when I stopped altogether. My quality of life and my mental health were in the toilet. The side effects were so bad it started to affect my job. Tried treating for fungal and demodex to see if it would help, and it never did. The rash was like a raised, red, hard-bordered rash that went down to my shoulders. Not as painful as the three years I did TSW, but I was younger then and that was 3 years long. Dupixent was just as painful for a shorter amount of time."

• Cra...
• Taken for 1 to 6 months
• January 5, 2022

For Eczema "Used this product for a total of 8 weeks. Initially, my body eczema went away. After about 8 weeks, my face began to become red, blotchy, itchy, and scaly. I never had eczema on my face to any great degree. Now my face is a complete disaster. I can't even go outside. This is not topical steroid withdrawal (TSW). This is something totally different, different. My eyelid skin became red and flaky. This was not listed as a common side effect."

• Win...
• Taken for less than 1 month
• October 15, 2018

For Eczema "2 weeks on Dupixent, and I have seen improvements. After a whole body breakout. After about the 2nd day, my skin started to scale and peel. I've never seen so much peeling skin. I am still peeling, just not as much, and my skin is starting to become smooth again. I've also been moisturizing all day long. In this 2-week time frame, my skin has also been red and pink in the areas that are broken out. I'm not too sure, but I think in the next 2 weeks, I should see more improvements."

• Sar...
• Taken for 1 to 6 months
• January 18, 2018

For Eczema "I have had eczema my whole life, from scalp to feet. It had been a nightmare. I started Dupixent about 4.5 months ago. About 2 weeks after getting the initial dose, I started getting cold sores weekly. My doctor put me on a daily dose of Valtrex, and that has subsided. It took about 2-3 months for my skin to clear up. My face and neck have cleared up, but not as well as the rest of my body. I still have peeling skin on my face and some redness. There is some eczema on my neck and chest. Overall, I am happy with the results. I am a lot less itchy. I just wish my face would heal as well as my body. Hopefully, in time, it will heal too."

• Roy...
• Taken for 1 to 6 months
• October 18, 2024

For Chronic Rhinosinusitis With Nasal Polyps "I'm a 75-year-old male taking Dupixent for 4 weeks. Almost immediately, I could breathe freely through both nostrils. Super grateful for that. I feel superior to things like grasses, dust, etc. I inject the 300 mg dose in a thigh biweekly. The last two times, it stung fiercely at the injection site for a few seconds. Not a deal breaker. Side effects such as eye sensations in, on, or behind the eye. It's hard to say what the feeling is there. The last two days, I notice sharp throbbing head pain when I stand up, so I try to take a little more time to stand up, and that helps. And last night, the headache was so bad I doubt I slept. In these four weeks, I've had at least two strong headaches, and those haven't been an issue for years. The pain is in the right temple area. There is way too much flaky skin along both sides of the nose, which I find interesting in that one use of Dupixent is for some kind of skin issue."

• Cob...
• Taken for 1 to 6 months
• October 21, 2024

For Atopic Dermatitis "I do the injection every other week. It has helped clear up my rashes, but unfortunately, it's causing my fingers to peel and itch. It's also causing my knees, hands, and hips to ache so bad."