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Diphenhydramine User Reviews & Ratings (Page 2)

Brand names: Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphen, Unisom SleepGels, Nytol, Sominex, Diphedryl, Benadryl Children's Allergy, Siladryl Allergy, Buckley's Bedtime, Diphenhist, Sleepinal, Diphenydramine Quick Melt, Snooze Fast, Unisom SleepMinis, Unisom Liquid, Diphenadryl, Beldin, Diphenylin, Twilite, Pharbedryl, Unisom SleepMelts, Sominex Maximum Strength Caplet, ConRx Allergy, Dicopanol, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Diphen Cough, DPH, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Aller-G-Time, Sleep Tab II, Nytol QuickCaps, Trux-adryl, Valu-Dryl, Diphenyl, Altaryl, Belix, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Silphen Cough, Hydramine Compound, Nytol Caplet, Compoz Nighttime Sleep Aid Help I Can't Sleep Allermax Diphendryl Banaril Aler-Tab Sleep-ettes D Diphenmax Ben-Tann Dytan Vanamine PD Histaprin Z-Sleep Simply Sleep Complete Allergy Relief Dytuss Dormin Miles Nervine Scot-Tussin Allergy Sleepwell 2-nite …show all brand names

Diphenhydramine has an average rating of 5.4 out of 10 from a total of 517 reviews on Drugs.com. 43% of reviewers reported a positive experience, while 41% reported a negative experience.

Reviews for Diphenhydramine

  • Just...
  • Taken for less than 1 month
  • May 9, 2020

Benadryl (diphenhydramine) for Allergic Reactions "This is an old thread but thought I would share. I was in the hospital in labor. I developed a reaction to the epidural that caused severe itchiness. They gave me something that didn't help and after several hours of itching, a nurse gave me iv benedryl. I immediately couldn't breathe and felt like someone kicked me in the chest. I was warm all over, nauseous and on the edge of passing out. An ekg also showed I had a heart arrhythmia from it. I've taken oral benadryl in the past with no problems. Now it's on my list of allergies and I tell every doc I see. Most terrifying experience."

1 / 10
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  • Sue
  • Taken for less than 1 month
  • July 12, 2019

Nytol (diphenhydramine) for Insomnia "I took the tablets at 11pm and am typing this at 3.19am. They seem to have had the opposite effect on me and are keeping me awake. It usually takes me about an hour to get off to sleep, and then I'm up several times in the night, so I thought I would give them a go, but I'm wide awake and feel absolutely alert. Needless to say, I won't be taking any more of them."

1 / 10
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38 Report
  • EDD
  • Taken for less than 1 month
  • January 17, 2021

Nytol (diphenhydramine) for Insomnia "First off I read the instructions on the box which says 2 things! Firstly you can take one an hour before you go to bed (mistake) as it won't work that fast and your even more awake cause your waiting for the effects!! Now the second point they make is much more advisable where you take one probably around I would say 6pm as it gives your body much more time to acclimatize to the product. For me I only took one just before I went to bed but it's much more a delayed reaction so I found that I was quite groggy the next day (mistake). So it definitely works and I had a few funny dreams but who cares? Probably try not to lay in bed too much when night becomes day and get your self into a good pattern as you will be trying to over compensate with nytol"

10 / 10
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Frequently asked questions

  • MarD
  • June 5, 2016

Benadryl (diphenhydramine) for Nausea/Vomiting "I had a couple surgeries on my jaw where I could not open it fully for an extended period of time. I am already semi-allergic to pain meds / anesthesia (excessive vomiting and nausea) so I was terrified to take my pain killers after surgery. The nurse / doctor recommended taking a couple Benadryl tablets (25mg) before the pain meds and it worked wonders! The only side effect is drowsiness."

10 / 10
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  • Levi
  • Taken for 6 months to 1 year
  • May 25, 2020

Nytol (diphenhydramine) for Insomnia "I take Nytol on nights I really can't get to sleep. My experience is that they don't work very fast, but when they do I sleep pretty soundly. Unfortunately, the result in the morning is that I feel like I have a hangover, and I often sleep through my alarms."

4 / 10
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31 Report

Are you taking this medicine?

  • jasmine
  • January 31, 2021

ZzzQuil (diphenhydramine) for Insomnia "I suffer from depression & anxiety so I also have insomnia. I know you don't wanna read too much lol so I'm gonna cut it short. I've had this around the house for a while and finally I decided to try it 15-20mins ago & I literally can already feel it. Honestly it has me feeling amazing just like other reviews. if you're deciding on trying it , DO IT ."

10 / 10
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  • Anonymous
  • Taken for 10 years or more
  • June 11, 2018

Benadryl (diphenhydramine) for Allergic Rhinitis "Benadryl really helps take the sinus pressure away and I found out recently it even worked best for my migraine. Out of Tylenol and Motrin Benadryl was the only one to knock it out. It does cause me dry mouth and drowsiness. It also helps to calm me when I feel a panic attack or anxiety coming on. I rather take benadryl then psych meds or all kinds of prescription meds anyday . I hope it stays working wonders for me because claratin and flonase did nothing for me and I don't want to have to try anything else."

10 / 10
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39 Report

More FAQ

  • Shy
  • Taken for less than 1 month
  • May 27, 2020

ZzzQuil (diphenhydramine) for Insomnia "I have been having a lot of issues with falling asleep lately, my sleepy time tea stopped working so I was looking for a non habit forming sleeping aid. So I tried Zzzquill. DOES NOT WORK!.. was really disappointed ...Actually it woke me up even more or I laid super restless for hours after taking"

1 / 10
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28 Report
  • jen
  • Taken for less than 1 month
  • March 22, 2023

ZzzQuil (diphenhydramine) for Insomnia "BEWARE!!! Had the worst night of my life. Hallucinated and ended up calling 911 to get to the hospital. My doctor confirmed it is the worst over-the-counter hallucinogen on the market. I have no idea how this is still available."

1 / 10
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  • astuder
  • February 28, 2013

Sominex (diphenhydramine) for Insomnia "I absolutely love Sominex. It works so great I fall asleep pretty fat and stay asleep which is so fantastic. Sometimes I wake up in the same position I fell asleep in. When I wake up it takes a few mins but once you start moving around you are fine. "

9 / 10
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60 Report
  • Anonymous
  • Taken for 2 to 5 years
  • June 13, 2017

Sominex (diphenhydramine) for Insomnia "I have been using sominex for a long time, I asked GP about it and he would rather I take it than prescribing me sleeping tabs, it works well for me, I take it at least an hour before bed, fall asleep easily and can still wake up for the bathroom and go straight back to sleep, feel fine on waking with no after effects, a great over the counter product."

9 / 10
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41 Report
  • M1k3
  • March 6, 2008

Sominex (diphenhydramine) for Insomnia "Sominex is a great mild sedative. Although it does have a bit of a hangover effect in the morning, this typically only lasts an hour or so. I've been taking this stuff nightly for about a week and it's the best over-the-counter stuff you can get for sleep."

8 / 10
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74 Report
  • Amensus
  • Taken for 10 years or more
  • April 28, 2016

Benadryl (diphenhydramine) for Allergic Reactions "I take one before bed which keeps me breathing easily during the night despite my allergies. It also helps me get to sleep and stay asleep. The active ingredient, dyphenhydramine HCL, you will find is the main ingredient in quite a few over the counter sleep medications so that should tell us something. And Benadryl or a generic drugstore brand are cheaper and just as effective. Have been taking this for over 20 years and have no side effects"

9 / 10
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  • Anonymous
  • Taken for less than 1 month
  • September 3, 2019

Sominex (diphenhydramine) for Insomnia "I’m the type of person to be terrified to try new drugs, always read up on the reviews etc. So I took half of this sominex pill, I’ve taken it 3 times now, before taking this pill I would have nightmares constantly, wake up 3/4 times in the night and sometimes stay awake. After taking half of the sominex pill, my nightmares have gone :) and I manage to sleep uninterrupted through the night, maybe wake up to wee/ wake up once or so. You do feel a bit groggy in the morning but that’s because it’s still in your system, takes around 12/13 hours to get out of your system so just take it in good time :) try it on a day off if you’re worried."

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  • Neil
  • March 23, 2021

Nytol (diphenhydramine) for Insomnia "I took nytol for the first after months of a lack of sleep and always feeling tired. Worse thing I could have tried. Seems this acts as a stimulant for me cause I couldn’t sleep all night and was wide awake tossing and turning. Now I’m even more tired. Won’t be trying them again"

1 / 10
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21 Report
  • Anonymous
  • August 10, 2021

Benadryl (diphenhydramine) for Allergic Reactions "Took benadryl for eight months on advice of PCP and Pulmonary specialist. I quit taking it because I began having short term memory problems. Checked it out on internet and found it should not be given to senior citizens. A neurologist at University Of North Carolina Memory Disorders unit said it should probably not be given to anyone as there are safer alternatives. I had nervous breakdown and spent several days in a mental hospital. Had two MRIs of my brain. Second showed small area that was due to the Diaphenhydramine use. Alienated my family because of things I said . Without the Benadryl I wouldn't be the most heart-broken 74 yr. old lady around."

1 / 10
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19 Report
  • Leo
  • Taken for less than 1 month
  • November 9, 2020

Nytol (diphenhydramine) for Insomnia "Worked well for me . You have to be tired anyway , so get some exercise , cut some caffeine , and take a nytol. Maybe they won’t knock you out like a Valium or other , but they give you a gentle push in the right direction. Once you get to sleep you remain asleep . Well I did anyway ."

10 / 10
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22 Report
  • Yeshus
  • March 26, 2013

Sominex (diphenhydramine) for Insomnia "I have taken Sominex for a few days now and still wake up after 2-3 hours sleep and can't get back to sleep again. I am so tired. Yet I can fall asleep in the chair really easy in the day. I was hoping Sominex would work but so far it really hasn't."

4 / 10
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49 Report
  • Manz
  • Taken for less than 1 month
  • March 8, 2019

Nytol (diphenhydramine) for Insomnia "I usually takes prescribed medication from the GP, due to constant pain. On asking for medication to sleep from the Doctor she recommended Nytol - got the absolute best nights sleep the first in a long long time of never ending sleepless nights. I think you have to believe the meds is going to work for it to work. I read the reviews about the product being useless. I totally disagree Nytol Blue suits me fine."

8 / 10
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27 Report
  • Agg
  • March 19, 2017

Sominex (diphenhydramine) for Insomnia "I believe this is the strongest non prescription sleeping aid that you can take. This works really well for me on the few occasions that I need it, within about 10 minutes of taking it, I fall asleep and stay so for longer than I normally would without it. You can even try 1/2 or 1/4 tablet if you don't want to take a whole one. . Definitely recommend this!"

9 / 10
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34 Report
  • Nic
  • Taken for less than 1 month
  • October 19, 2020

Benadryl (diphenhydramine) for Allergic Reactions "Received Benadryl via IV in prep for a biologic infusion. My throat starting swelling and my blood pressure skyrocketed. An immunologist tested me, and I showed strongly allergic to Benadryl, so it can happen."

1 / 10
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20 Report
  • Hideous...
  • Taken for less than 1 month
  • March 30, 2023

Nytol (diphenhydramine) for Insomnia "Couldn’t believe the effect these things had! Rather than falling asleep I was irritated, restless and slept almost zero minutes all night. Never again. Save your money, not only does this product not help you sleep but achieves the exact opposite!"

1 / 10
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  • Anonymous
  • January 7, 2012

Benadryl (diphenhydramine) for Cough "Variant asthma, chronic, have been on many antihistamines and other costly asthma medicines over the years. I began taking Benadryl in late November 2011. Taking 25 mg after awakening in the morning followed an hour or so later with 25 mg with another 25mg early afternoon (when symptoms occur) and 25 mg prior to bedtime in conjunction with Symbicort twice/day. I have a much improved quality of life and am beginning to have some control over the chronic cough. "

9 / 10
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48 Report
  • LilLi...
  • Taken for less than 1 month
  • June 4, 2020

ZzzQuil (diphenhydramine) for Insomnia "I was trying to get my sleep schedule back on track since quarantine, so I turned to Zzzquil as opposed to my usual melatonin 10mg dose. I can say I was wildly disappointed with the results. It made me drowsy, and I could fall asleep, but then I’d either wake up frequently, or stayed wide awake all night until morning. I gave it a weeks worth of a chance before I threw about half the rest in the trash."

1 / 10
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  • Lucky
  • October 3, 2018

ZzzQuil (diphenhydramine) for Insomnia "Diphenhydramine is a fantastic sleep aid, but you need to follow the dosage very, very, carefully. I've struggled with insomnia since basically puberty, and few years back I began taking zzzquil daily. I slowly grew a tolerant to it, and increased my dosage eventually to 100mg. One night I was so fed up with tossing and turning, I took another 100mg (I was 19, ok?). An hour later I was watching the walls ripple like the surface of a pond, little black dots crawling up the walls here and there, and full blown auditory hallucinations. (I.e. I heard orchestra music coming from the bathroom vent fan amidst its hum). I felt like my body was made of lead, and was horribly lethargic. Still after tossing and turning for hours, I eventually made it to sleep, and felt as if I was awake the entire time. My room mate said I talked in my sleep the entire duration of my slumber, and my dreams were very vivid and unsettling. I felt like a trainwreck the next day until I could finally go home and sleep."

8 / 10
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27 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.