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Dextroamphetamine and Depression: What Users Say

Brand names: Dexedrine, ProCentra, Xelstrym, Zenzedi

Depression: mentioned by 9 users (3.1%)

Based on user experiences from 295 Dextroamphetamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 14.2%
insomnia 5.1%
tiredness 4.7%
dry mouth 3.7%
depression 3.1%
irritability 2.7%
fatigue 2.4%
headaches 2.4%
loss of appetite 2.4%
sexual dysfunction 2.4%

Reviews for Dextroamphetamine

Commonly mentioned side effects
  • Meg...
  • Taken for 1 to 6 months
  • January 19, 2017

Dextroamphetamine for ADHD "I wrote previously about loving Zenzedi and switching to Adderall XR due to insurance. After one month of Adderall, I am going back to Zenzedi. Adderall was just not for me. I had mental issues all month long and just didn't focus as much. My family even noticed a difference. I called my insurance and they approved Zenzedi easily."

10 / 10
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62 Report
  • Ric...
  • Taken for 1 to 2 years
  • April 16, 2023

Dextroamphetamine for ADHD "I have a positive experience. I was running around with anxiety, depression, and panic attack. I was on all kinds of antidepressants, then my doctor put me on Dexedrine, the best thing that ever happened to me."

10 / 10
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16 Report
  • The...
  • Taken for 10 years or more
  • August 20, 2015

For ADHD "I have been taking dex on and off for 21 years. Since I was young, I lived in a haze. I didn't have the drive to undertake the most basic activities. I was also depressed. This haze stayed with me until I was 15 years old, when I was first prescribed dex. My mood went from sullen to elevated, and my ability to focus was there for the first time in my life. The school term that I commenced dex, I duxed my year in chemistry. I am very happily married with 1 happy child so far. I take 7.5 mg per day. I have no sugar or gluten in my diet. A point of this advice is to take holidays from dex and to take it with acetyl-L-carnitine as it inhibits any cortisol overproduction, a side effect of dex. You will likely be very grateful for this synergy."

9 / 10
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38 Report

Frequently asked questions

  • Tar...
  • Taken for less than 1 month
  • November 2, 2019

For ADHD "Finding that starting this medication can be very tricky, as it will work differently for so many with ADHD. I've found the small dose makes me very tired and lethargic, with no motivation. Going up in doses is trial and error, and unless you're very patient or have the ability to experiment, this could take a long time to find the right dose and top-ups. Coming back to your ADHD self can be very depressing too."

4 / 10
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10 Report
  • Tar...
  • Taken for less than 1 month
  • November 2, 2019

For ADHD "Finding that starting this medication can be very tricky, as it will work differently for so many with ADHD. I've found the small dose makes me very tired and lethargic, with no motivation. Going up in doses is trial and error, and unless you're very patient or have the ability to experiment, this could take a long time to find the right dose and top-ups. Coming back to your ADHD self can be very depressing too."

4 / 10
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10 Report

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  • Lco...
  • Taken for 1 to 6 months
  • March 25, 2016

Dextroamphetamine for ADHD "Dexedrine is okay! When I first took it, I was excited and hoped to feel something. I was instantly in a good mood, more focused, and patient. However, the come down off this drug is horrible. The depression and sadness start to come back, and it's just discouraging that only a medication can band-aid those emotions. I have felt overstimulated as well. I had a gastric bypass four years ago, so my doc said no XR, but he put me on four 10 mg a day, which I feel is too much. I become agitated, irritable, paranoid, panicky, crying, etc. I decreased it to two a day. I feel that this might be too strong of a stimulant for me. I want to try Adderall since it's cheaper on my insurance and it has less dex. We'll see what he says at my next visit."

5 / 10
Was this helpful?YesNo
15 Report
  • Lco...
  • Taken for 1 to 6 months
  • March 25, 2016

Dextroamphetamine for ADHD "Dexedrine is okay! When I first took it, I was excited and hoped to feel something. I was instantly in a good mood, more focused, and patient. However, the come down off this drug is horrible. The depression and sadness start to come back, and it's just discouraging that only a medication can band-aid those emotions. I have felt overstimulated as well. I had a gastric bypass four years ago, so my doc said no XR, but he put me on four 10 mg a day, which I feel is too much. I become agitated, irritable, paranoid, panicky, crying, etc. I decreased it to two a day. I feel that this might be too strong of a stimulant for me. I want to try Adderall since it's cheaper on my insurance and it has less dex. We'll see what he says at my next visit."

5 / 10
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15 Report
  • Bak...
  • Taken for 1 to 6 months
  • April 6, 2022

For ADHD "I have tried all stimulant types and formulations out there, and dextroamphetamine is by far the best. The other stimulants would make me depressed and anxious at the end of the day, dextroamphetamine wears off very smoothly and doesn't cause any anxiety or depression."

9 / 10
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4 Report
  • Joh...
  • Taken for 2 to 5 years
  • January 13, 2021

For ADHD "I have been on ADHD meds for over 34 years. Dexedrine generic had always worked until 5 years ago. From TEVA, they are now worthless. They cause depression and other weird things. I thought it was just me, it is so helpful to find other people having the same bad experience."

1 / 10
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5 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.