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Denosumab User Reviews & Ratings (Page 4)

Brand names: Prolia, Xgeva, Jubbonti, Wyost

Denosumab has an average rating of 2.9 out of 10 from a total of 386 reviews on Drugs.com. 17% of reviewers reported a positive experience, while 75% reported a negative experience.

Reviews for Denosumab

  • Tup...
  • Taken for 6 months to 1 year
  • August 26, 2016

Prolia (denosumab) for Osteoporosis "I am in the UK and therefore am 'lucky enough' not to have paid for my treatment. However, I understand this is a relatively expensive drug for the National Health Service to prescribe. I have had two six-monthly doses, and I will certainly not be having the third despite having severe osteoporosis. I have experienced no positive results from this drug, only debilitating pain, stiffness, and general flu-like symptoms which come and go regularly day and night with no prior warning. My worst experience was a spot on my lower jaw bone that grew until it literally erupted, leaving a 2mm diameter hole in the side of my face. (2 months of antibiotics) I can find no positive feedback to justify this drug's side effects."

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  • M H...
  • Taken for 1 to 2 years
  • April 17, 2016

Prolia (denosumab) for Osteoporosis "Prolia shot given July 26, 2012! Immediately had every dermatological problem listed in the ad: Itching, rash all over body except for face, extreme pain, dry skin, repeated biopsies, thousands of dollars for doctors, prescriptions, lotions, and potions. Left calf's skin completely peeled off like the bark of a tree and has never recovered four years later!! Even now it is again broken out in oozing rashes around the ankle, but the entire leg hurts. I must keep the hair on my legs shaved very close or when I am exercising in the Y pool, the leg is painful just with the movement of the tiny hairs in the water. The pain is inside as well as on the surface of my skin. These bad side effects continue! Have pictures of early rash available."

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  • Dia...
  • April 28, 2016

Prolia (denosumab) for Osteoporosis "This drug has been a nightmare. I have experienced unexplained bone pain in lower left leg and a breakout of bleeding gums and mouth sensitivity. I did not get any info from the prescribing endocrinologist except that it was a safe drug and that he had prescribed it to his mother! This has been a very expensive lesson in terms of dental costs and extremely detrimental to my health and well-being."

2 / 10
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Frequently asked questions

  • Oh ...
  • May 1, 2016

Prolia (denosumab) for Osteoporosis "I have been on Prolia for approximately two years. Just this year ( my 5th injection) I did experience sore muscle/joint pain in my hips. About 4 months ago I developed dermatitis around the corners of my eyes, nose, mouth, and along both sides of my neck. I've never had allergies before. Also, I'm dealing with a feeling of deep exhaustion. I'm not sure whether this is due to Prolia. If my next bone density doesn't show marked increase, I will ask my physician for a change in med. One note--I faithfully exercise 3-4 times weekly with a trainer, take calcium, and eat green veggies and foods with calcium/D."

6 / 10
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  • Joe...
  • Taken for 2 to 5 years
  • September 6, 2018

Prolia (denosumab) for Osteoporosis "Prolia has been an absolute nightmare for me, and from the reviews of this drug, I am not alone. I wish I had done my homework before ever taking the first injection. I trusted my doctor! I have suffered most of the horrible side effects of Prolia, real drug Denosumab, now being used for bone cancer patients!! So yes, a form of chemotherapy?? I am not sure my body will ever be rid of this poison, and my last shot was in 2015!! I have reported it a number of times to the FDA, to no avail. I warn everyone and hope to spare others from the suffering I have and am still going through, BEWARE OF PROLIA!! Hope this post helps someone."

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  • Hea...
  • Taken for 6 months to 1 year
  • December 12, 2019

Prolia (denosumab) for Osteoporosis "I have osteoporosis with no symptoms as I’m extremely fit and healthy. I resisted Prolia as I take no drugs at all. After one year, bone density improved 7.6% in hip and 2% in spine. A week ago, my gum was bleeding, and I sorted it. Today, I had the third injection. I’m writing this also to see if they publish positive stories, as all that I just read were mostly negative. My brother is a doctor and encouraged me to do it. I weigh 56 kg. I have always eaten good food and stayed slim and well. So far, so good for Prolia, the only drug I have ever taken."

8 / 10
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  • Maz...
  • October 16, 2018

Prolia (denosumab) for Osteoporosis "My doctor gave me the prescription for Prolia yesterday. I explained to her I would research the drug before making a decision. I was horrified after reading ALL the possible side effects. However, after reading the above reviews, I will never take this drug. Thank you to all the people who wrote reviews. I am shocked that this drug could ever be approved by the FDA."

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More FAQ

  • sha...
  • March 11, 2017

Prolia (denosumab) for Osteoporosis "My mom got this shot a month ago and her life has been hell. Extreme pain that she ended up in the hospital getting injections for pain and on morphine. Extreme headaches to where she cannot function, along with godawful headaches. Jaw pain, muscle cramps, fevers, stomach issues, bladder issues, short-term memory issues, and with all this happening she is now depressed from all the issues which now gives her anxiety wondering if these will go away or not. The sad thing is that not all the symptoms show up right after the shot. They show up weeks later and no one can tell you how long they will last."

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  • Ree...
  • Taken for 1 to 6 months
  • November 5, 2019

Prolia (denosumab) for Osteoporosis "On my last visit to the cancer center, they put me on a new injection for osteoporosis (Prolia) and had to sign a form to take it. Like a lot of you, I trusted my doctors and took the shot back in September 2019. OMG, I was not ready for what I was in for with the side effects. I have no energy, my legs feel like they give out after 10 steps, making me take a break. My bones hurt all the time, which they did anyway with the hormone blocker, but this just intensified it. I have no appetite, can't sleep, and my memory is horrible. I have a very multitasking job, and it has been tough keeping up with everything. It feels like it's all about the almighty dollars with these doctors, and I will not take this drug again. One thing I have found concerning osteoporosis is there are classes called Osteo Strong that help build bone naturally in your body, and you attend once a week."

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  • Pro...
  • May 30, 2016

Prolia (denosumab) for Osteoporosis "I did not know, nor was I given any information on this injection. About 1 month in, I experienced hair loss in places. Have a tingling around the lips. I felt very nauseous on and off out of the blue. Am very tired and just cannot get rid of chest infection/cough which just seems to be on loop... I think it's clearing up then it hits again. I will not get this injection again. Nothing is conclusive about the cause of what I am experiencing."

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  • Pat...
  • Taken for 1 to 6 months
  • April 7, 2016

Prolia (denosumab) for Osteoporosis "I had my first injection in Oct 2015 and am due again in April. Is the 2nd shot any better than the first one? I experienced flu-like symptoms the first couple of days, then constant constipation, acid reflux, extreme tiredness, and itching. My doctor informed me that I should not undergo any dental procedures while on this medication, such as a root canal. What other medications can be taken? Or is a natural approach the best way to go? Speaking to naturopaths, they suggest that these medications disrupt the entire immune system. They advise against injections."

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  • Lac...
  • November 24, 2019

Prolia (denosumab) for Osteoporosis "I’m so sorry I ever took Prolia shots. After 4 injections, I am in constant terrible pain. I am 66 years old and was so healthy and mobile before the Prolia. Now, leg, hip, arm, and jaw pain. Barely walking now. Taking physical therapy but no relief. This drug should NOT be on the market!! Does anyone know if, after discontinuing the Prolia, this stuff ever leaves our bodies?"

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  • Mol...
  • Taken for 6 months to 1 year
  • November 14, 2019

Prolia (denosumab) for Osteoporosis "1st Prolia needle ok, 2nd needle within 2 weeks I got so many side effects of joint pain. Unbelievable arms, legs, even tips of shoulders were sore to touch. I am tired and can’t do what I want to do. My appetite is not good and I have lost weight. I should have looked into Prolia side effects. I would not wish this on anyone. My thoughts and prayers go out to anybody who is on this awful drug Prolia."

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  • Lak...
  • Taken for 1 to 2 years
  • July 10, 2016

Prolia (denosumab) for Osteoporosis "Various side effects including fractures in both feet and bad pain and aching in right leg making it almost impossible to walk and keeping me awake and in pain. It is time for my third Prolia shot and I have suffered from this for two months and am no better. This has not been a positive experience but a bad and painful one leaving me unable to get out and perform any daily tasks or functions."

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  • Bre...
  • Taken for 6 months to 1 year
  • January 2, 2021

Prolia (denosumab) for Osteoporosis "Had a wedge compression fracture in August 2019, doctor ordered Prolia injection. Wish I had never had it, developed stomach and intestinal problems, reflux (never had any problems with that before), pain in groin (a cyst on ovary was found), increased pain in neck, had an increase in blood pressure, pulse rate increased, pain in arms, legs, and continue with pain in back, muscle soreness, and weakness. Was diagnosed with Barrett's Esophagus in January 2020. Never will allow another injection, and of course, doctors don't believe it caused these problems."

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  • XGy...
  • Taken for 1 to 6 months
  • November 25, 2019

Prolia (denosumab) for Osteoporosis "This is now 1 year, 1 month from my one and only Prolia injection. Reading the other comments from patients who have had poor to terrible side effects, I am certain that one dose of Prolia likely still lingers in my system and the side effects continue. My bone and muscle pain kicked in with a vengeance and has not abated. Walking became and remains difficult due to body pain and loss of strength/balance/pain in addition to which, my skin rashes causing both pain and itching continue. I regret being talked into taking Prolia even though my osteoporosis remains seriously advanced. All of the side effects continue although I only had the first injection due to the severe reaction that kicked in within a few days. Note: Amgen is recently promoting a 'new' drug 'Evenity' ... an almost identical to Prolia... which has major warnings, actual black boxed warning - some even worse than the Prolia warnings. Doctors continue to advise trying the drug. For me, that is not an option."

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  • Geo...
  • Taken for 1 to 2 years
  • November 18, 2016

Prolia (denosumab) for Osteoporosis "While the bone test indicated a slight improvement, I don't feel it is worth it. The first time I had the Prolia shot, I had no reaction. After the second shot, my hair began to fall out in bunches. It has continued to fall out, and it looks as though I will have to wear a wig. Has anyone else had this problem, and does it go away after the drug wears off? I will never take another dose of Prolia, and would not recommend it after reading all the negative posts on this site. It would seem that my problem is small compared to others."

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  • Pai...
  • Taken for 1 to 6 months
  • June 5, 2023

Prolia (denosumab) for Osteoporosis "I had my first and last injection on Dec 15, 2022. The first month was fine, didn't notice a thing. But then, my hips became very sore, my muscles hurt, and I have difficulties walking without pain management. My bedside table is full of pain relief. I have rheumatoid arthritis and take Rinvoq. It is well controlled, however, with the layer of permanent pain, I have no control over how well my other medication works. How can they sell a product which, after you stop it, makes your life even worse? It should not be allowed. I also read through the large study and can't see the benefit of it when your life turns into a pain management exercise. Just don't take it."

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  • Jja...
  • Taken for less than 1 month
  • September 12, 2018

Prolia (denosumab) for Osteoporosis "DO NOT TAKE THIS! My grandmother took this needle on a Tuesday, her behavior changed almost immediately. She became very weak, could not stay awake, her breathing changed and as the week progressed, she got worse. Sunday of the same week, her heart rate was jumping between 70 and 120 bpm, and her oxygen went down to 90. She was rushed to the hospital and has rashes, water in the lungs, she can't talk because she is so congested, and has to be on a special mask for oxygen. She is definitely not the same in a matter of 5 days. I've also noticed she has developed a lot of involuntary movements all over her body - arms, legs, hands, and even eyes. We actually thought she was going to pass away on the Monday after being admitted to the hospital. We were called to have an emergency meeting with the doctor. She only has had one shot and WILL NOT have any more. Please do your research before taking this needle. Biggest mistake."

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  • Anonymous
  • Taken for 2 to 5 years
  • August 24, 2023

Prolia (denosumab) for Osteoporosis "I'm having severe pain. Such a dilemma. Degenerative back problems or chronic pain from Prolia...from walking to feeling crippled. It feels like the drug causes severe inflammation. I have eczema, another side effect."

5 / 10
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  • Luc...
  • Taken for 1 to 2 years
  • October 12, 2019

Prolia (denosumab) for Osteoporosis "My first 2 shots of Prolia were positive, and my T-score improved by 25% in my hips and back from -2.8. I took my 3rd shot in July 2019 and have been having increased pains ever since, from my hip folds all the way down to my toes, in my lumbar spine region, and in my ribs. I get severe headaches on and off and experience nausea (extremely flu-like) every day. The doctor never mentioned the side effects of Prolia, and I trusted him so much that I didn’t do any investigating before taking it. I also have what seems like a never-ending cold. Even nasal spray gives very little relief. I’ve been to my new GP doctor twice since my 3rd shot, but she has never seen a connection between my symptoms and Prolia. I put a message in MYCHART yesterday saying I am done with Prolia! It’s not worth being sick all the time."

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  • A...
  • Taken for less than 1 month
  • April 15, 2023

Prolia (denosumab) for Osteoporosis "I was recently diagnosed with osteoporosis in my lumbar spine. I am a healthy, very active, 55-year-old postmenopausal woman who loves drinking milk. I am on hormone replacement therapy (HRT) and prescription vitamin D. I have been taking thyroid replacement for over 30 years, which could be a contributing factor. The rheumatologist's initial recommendation was Prolia, as she believed it to be highly effective. I received the shot three weeks ago, but I have been experiencing persistent achiness in my bones and muscles that seem to have settled in and worsened over the past two weeks. I have also noticed a significant decrease in lifting and muscle strength, as well as reduced physical endurance. Despite my efforts, I am unable to lift objects that I should be able to and fatigue easily. It is evident that Prolia is not the right medication for me, and I will not be getting another injection. I am too young to allow this disease to progress without taking any action, and I will be exploring other medication options in addition to implementing lifestyle changes and vitamin support."

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  • Jud...
  • June 13, 2016

Prolia (denosumab) for Osteoporosis "I am having severe jaw pain, almost unbearable. It is one of the most horrible experiences I have ever gone through. Will not take this drug again. What is strange is that I didn't have a problem until after the second shot. Since then have not only teeth pain but sick with sore throat and cold. Also bad digestive problems."

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  • Til...
  • May 30, 2017

Prolia (denosumab) for Osteoporosis "Three days after receiving my first Prolia injection, I developed a cough which turned into bronchitis and was treated with antibiotics - bad luck, a coincidence I thought. A month later, my life changed with severe bone pain in my right jaw. I had lockjaw five times. Pain in my right shoulder, ribs, and my neck was so stiff, but worse was my lack of mobility. My morning walk to the bathroom was just like watching Frankenstein walk, I couldn't move any faster because of the pain. Getting on and off the toilet was a major event. Turning in bed was excruciating and sometimes impossible. This lasted the whole summer of 2015, which eventually tapered off to where I am today. Worst experience of my life. No more Prolia for me."

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  • Suz...
  • Taken for 1 to 2 years
  • April 7, 2019

Prolia (denosumab) for Osteoporosis "I’ve decided to come back to this site to leave an update on my last review. I received my 2nd shot of Prolia in January 2017. The side effects were very severe for 9 months. They are tolerable now, but I realize I will never be the same and will always suffer pain from this medicine. The damage is done and just has to be dealt with. I do not recommend this drug. I believe my doctor took the word of the drug rep instead of doing her own research about this drug as she had never heard of any bad side effects. Please do your research before starting this drug. The damage is permanent."

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.