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Denosumab Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Denosumab Alendronate Calcium / vitamin d
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Denosumab Alendronate Calcium / vitamin d
Prescription only

Denosumab is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation... View more

Prescription only

Alendronate helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a... View more

Over-the-counter

Prescribed for Osteoporosis, Dietary Supplementation. Calcium / vitamin d may also be used for purposes not listed in this medication guide.

More about Denosumab More about Alendronate More about Calcium / vitamin d
Ratings & Reviews

Denosumab has an average rating of 3.0 out of 10 from a total of 388 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 75% reported a negative effect.

Alendronate has an average rating of 2.7 out of 10 from a total of 182 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 80% reported a negative effect.

Calcium / vitamin d has an average rating of 7.1 out of 10 from a total of 11 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 13% reported a negative effect.

View all 388 reviews

View all 182 reviews

View all 11 reviews

Drug Class
Side Effects

Denosumab side effects

Alendronate side effects

Calcium / vitamin d side effects
Generic Availability

N/A

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 4 tablet
Dosage 70 mg
Per Unit* $4.51 - $7.72
Cost* $18.03 - $30.89

View all Alendronate prices

We could not find an exact match for this medicine. Try searching the Price Guide directly.

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Dosage Forms Available

N/A
  • Oral solution
  • Oral tablet

N/A
Brand Names
Jubbonti, Prolia, Wyost, Xgeva Binosto, Fosamax Calcarb with D, Calcet, Calcet Petites, Calcio Del Mar, Calcitrate with D, Calcium 600 D, Caltrate 600 with D Plus Soy, Caltrate 600+D, Caltrate Colon Health, Caltrate Gummy Bites, Caltro with Vitamin D, Calvite P, Chewable Calcium with Vitamin D, Citracal + D, Citracal Calcium Gummies, Citracal Calcium Pearls, Citracal Maximum, Citracal Petites, Citracal Plus Heart Health, Citracal Regular, Citracal Regular 250 mg + D, Citracal Slow Release 1200, Citrus Calcium with Vitamin D, Dical Captabs, Dical-D, Dicalphos plus D, Os-Cal 500 Chewable, Os-Cal Calcium+D3, Os-Cal Extra D3, Oysco 500 with D, Oyster Shell Calcium with Vitamin D, Oyster-D, Oystercal-D, Posture-D H/P, Risacal-D, UPCal D, Wellesse Liquid Calcium with Vitamin D View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

609.6 hours

N/A

N/A
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out
Drug Interactions

A total of 298 drugs are known to interact with Denosumab:

  • 5 major drug interactions (11 brand and generic names)
  • 293 moderate drug interactions (849 brand and generic names)

A total of 117 drugs are known to interact with Alendronate:

  • 3 major drug interactions (8 brand and generic names)
  • 109 moderate drug interactions (1878 brand and generic names)
  • 5 minor drug interactions (45 brand and generic names)

A total of 275 drugs are known to interact with Calcium / vitamin d:

  • 17 major drug interactions (68 brand and generic names)
  • 205 moderate drug interactions (1624 brand and generic names)
  • 53 minor drug interactions (355 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Food may reduce the absorption of alendronate, which may lead to lower blood levels of the... View more
  • Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid... View more
Disease Interactions
First Approval Date

N/A

September 29, 1995

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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