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Prempro and Hair Loss: What Users Say

Hair loss: mentioned by 5 users (7.5%)

Based on user experiences from 67 Prempro reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 26.9%
night sweats 11.9%
weight gain 11.9%
bloating 10.4%
cramps 9.0%
hair loss 7.5%
sore breasts 7.5%
depression 6.0%
moody 6.0%
acne 4.5%

Reviews for Prempro

  • Vik...
  • Taken for less than 1 month
  • November 18, 2019

For Postmenopausal Symptoms "I'm 44 years old. I haven't had a period in over 4 years. My hormones were out of whack. My symptoms I was having were hair loss, hot flashes, and I was mean and hateful. My doctor put me on Prempro. I've been on it for a month now... Hot flashes are gone. My hair stopped falling out. My breasts didn't get too bad tender, but they did get fuller. My mood has not changed, I'm still moody. I already had acid reflux, and Prempro made it even worse! My feet feel a little swollen, or at least my shoes feel tighter. And I do feel a little bloated. I've decided to stop taking Prempro. I would rather deal with the hot flashes and hair loss than the acid reflux flare-ups."

8 / 10
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28 Report
  • Kik...
  • Taken for 1 to 6 months
  • August 10, 2018

For Postmenopausal Symptoms "I was prescribed Prempro by my gynecologist in April 2018. After taking it for one week, my period came, and I had a huge bald spot on the side of my head! I only took it for a week, I stopped, and now here I am, 4 months later, the back of my nape area, my hair is all gone!"

1 / 10
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18 Report
  • Kik...
  • Taken for 1 to 6 months
  • August 10, 2018

For Postmenopausal Symptoms "I was prescribed Prempro by my gynecologist in April 2018. After taking it for one week, my period came, and I had a huge bald spot on the side of my head! I only took it for a week, I stopped, and now here I am, 4 months later, the back of my nape area, my hair is all gone!"

1 / 10
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18 Report
  • Ano...
  • Taken for 1 to 6 months
  • January 1, 2025

For Postmenopausal Symptoms "I’m 54 and have been experiencing menopausal symptoms since I turned 50. After 4 years of suffering from hot flashes, night sweats, sleep deprivation, and worsening vaginal dryness/discomfort, I decided to start Prempro at the lowest dose. I’ve been on it now for about 6 months. After 2 weeks of taking it, my hot flashes and night sweats were completely gone. It was truly amazing. My sleep and my vaginal symptoms improved too. However, after about 3 - 3 1/2 months of taking it, I noticed significant hair loss. I thought my body just needed more time to adjust, so I kept taking it and my hair kept falling out, and it didn’t let up. It’s become so thin. Now I’m in the process of weaning off of Prempro because I don’t want to go bald. It’s so depressing because it was helping me in every other way. But it’s either go bald and feel good or keep my hair and feel horrible. Again, depressing."

7 / 10
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1 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • February 21, 2022

For Postmenopausal Symptoms "Have been on Prempro for almost a year. Did help with the hot flashes. I do experience a lot of headaches. I have also had a lot of hair loss since taking this. Just got a letter from my pharmacy saying they will no longer pay for Prempro and giving me covered alternatives, such as Estradiol-norethindrone acetate, Fyavolv, Jinteli, Mimvey, and norethindrone-ethin estradiol. Does anyone take any of these HRT alternatives? If so, what is your experience? Also, has anyone had hair loss from Prempro or any other HRTs?"

7 / 10
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5 Report

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