Skip to main content

Wellbutrin for Depression User Reviews (Page 3)

Wellbutrin has an average rating of 6.9 out of 10 from a total of 505 reviews for the treatment of Depression. 61% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Wellbutrin

  • young...
  • April 17, 2019

"After a few bouts of mild depression, I entered a more major depressive period about two years ago. I told my psychiatrist I was so sad 'my teeth hurt'. I was unmotivated, hopeless, and really just sooo sad all the time. My doctor tried to give me an SSRI but I pushed for Wellbutrin due to the lack of sexual side effects and weight gain with SSRIs. The first couple of weeks on it, I was on a total high. I remember dancing around with my kids and literally jumping around at the playground like a crazy lady. Once that levelled off I was just 'me' again. No other way to put it than I feel totally normal now. I still get sad, happy, angry (so I'm not flat) but all within a normal range. The ONLY negative for me is that if I miss a dose I turn into a raging crazy lady. I feel like I'm withdrawing from hard drugs. It definitely makes me scared of when the time comes to try and get off of it, but for now it's worth it."

9 / 10
Was this helpful?YesNo
121 Report
  • Kathe...
  • Taken for less than 1 month
  • July 20, 2014

"I am on Day 3 and I am starting to notice some if not all of the effects. My mood is stabilizing and I am finding my motivation returning to me. I need it for when I get into my doctoral program! I can find pleasure in things I enjoy again. I don't have overtly pessimistic and sad thoughts as much. I'm not crying as much. Before I started taking this medicine, I was not at rock bottom, but I did not want to feel awful anymore. Depression is a real disease. The medications do help."

10 / 10
Was this helpful?YesNo
184 Report
  • nebMN
  • Taken for 6 months to 1 year
  • February 7, 2014

"I was diagnosed with major depressive disorder a few years ago. I've tried basically all SSRI antidepressants. They did nothing for me other than make sex impossible, gave me leg tremors, as well as massive weight gain. I switched to Wellbutrin, and my sex drive is back to normal, my weight is dropping, and I feel a lot better. I recommend this medicine to anyone struggling with SSRIs and their many side effects."

9 / 10
Was this helpful?YesNo
190 Report

Frequently asked questions

  • Janedoe
  • March 7, 2020

"DO NOT TAKE THIS IF YOUR PRIMARY ISSUE IS ANXIETY. I got on this medication because I was having trouble with anxiety and insomnia. My NP wanted to start me on Wellbutrin 150mg XL and I kept reiterating to her that I have no depression whatsoever, I’m just anxious, but she said it would help. Within 2 weeks, I was so nauseated, in a complete brain fog, my anxiety got so much worse, my heart would race, I was having panic attacks daily, couldn’t sleep, my mind was racing non-stop, and although I’ve never felt as if I had issues with depression, I was so depressed on this medication! I went from being very high-functioning with mild to moderate anxiety to completely useless on this medication. I called into work multiple times (which I had never done before - I’m a nurse). I couldn’t focus, was so disoriented, and felt like I was just floating. I stopped and feel much better after a few days and I got on a PRN benzo for anxiety."

1 / 10
Was this helpful?YesNo
98 Report
  • Miami...
  • August 7, 2013

"I am a 25-year-old woman and started taking this 6 days ago along with clonazepam for anxiety. 300 mg of Bupropion once a day (mornings) and clonazepam twice a day (once in the morning and once in the evening). I have to say that... so far THIS ROCKS. I was suffering from depression, obsessive thoughts, anxiety, and panic attacks for months. I stopped taking Zoloft after a year because I gained 60 lbs on it. Now with Wellbutrin, I have no side effects except loss of appetite and more energy. I feel more energetic, happy (almost 'giddy') and hopeful for the future. My anxiety and depression were debilitating, and this saved my life. I can't wait till the full effects kick in. 6 days in and I feel the difference."

9 / 10
Was this helpful?YesNo
194 Report

Are you taking this medicine?

  • jaf
  • April 1, 2013

"I'm a 19-year-old college female. I was struggling with anxiety and depression for about six months and went on Zoloft in December 2012. It made me even more depressed, even though it helped with the anxiety. Zoloft also made me a zombie (napping for hours during the day, no motivation to socialize, no motivation to do schoolwork, nothing). I went off it about a month ago and switched to 150mg of Wellbutrin daily. I noticed a difference the FIRST day. It gave me the energy/positivity I have been lacking for months, and I finally am starting to feel like myself again. I recommend it to anyone who Zoloft didn't work for or who needs that extra boost to come out of a fog."

10 / 10
Was this helpful?YesNo
198 Report
  • AAnon...
  • November 13, 2014

"I was on Prozac and felt tired all the time, still depressed, and no sex drive. I thought maybe the dose wasn't enough and I was going through menopause, but the doc put me on Wellbutrin. I'm with the person above, I cannot believe in one day I felt better. I thought it was in my head. I made phone calls I would avoid because of anxiety, I got things done instead of sleep, and I felt so much happier next to my husband. Day two I woke up ready to start the day, completely the opposite of what I had been experiencing. Everyone is different, and you just have to see what works for you. Prozac is in a different class, and I just needed this antidepressant."

10 / 10
Was this helpful?YesNo
176 Report

More FAQ

  • Caro
  • Taken for 1 to 6 months
  • April 19, 2017

"I have been taking 150 mg of the generic of Wellbutrin for the past month. I can't believe how amazing I feel! After dealing with depression for the past 4-5 years, I finally feel like myself again. I was diagnosed with PMDD and mild depression but tried to deal with both of these with Prozac and hormone birth control. After three months of Prozac, I quit. It made me tired and took away my libido. It didn't help my depression at all. I've tried three different birth controls (I'm 46... it wasn't for birth control, just to try to help my hormone levels.) Nothing helped my depression. Finally, my doctor prescribed Wellbutrin. I filled it but didn't take it for 8 months because I was afraid of the side effects. Now I could just kick myself!"

9 / 10
Was this helpful?YesNo
140 Report
  • Meano
  • Taken for less than 1 month
  • September 24, 2018

"Have been on Wellbutrin SR 150 twice daily. BEST CHOICE I MADE!! I am a person that thrives off of happiness, feeling great, making others happy, etc! After one week, I am me again!!! HAPPY, SECURE, JUST ME!! I noticed it has helped chill me out. For those who don’t find this medication to work, maybe it is the wrong drug for your chemical imbalance. It is just a matter of finding the right drug for the right person. I'm thankful"

9 / 10
Was this helpful?YesNo
115 Report
  • Butte...
  • Taken for 1 to 2 years
  • October 22, 2013

"Bupropion has been the best ad for my very difficult-to-treat atypical depression. I gradually felt improvement as my doctor increased my dosage over the course of the year. It was helping a little when I first started at 150 mg, but I felt it could do far more. It's been amazing at 450 mg, my current dose. I'm level-headed, focused, and not at all exhausted. I was so tired and wanted to sleep. It also helps me with my addiction to food as I've been captive to this my entire life. I'm slowly losing weight because I'm walking a lot more and not binging. I sleep great too, and I do not feel agitated or nervous. I don't want to consume alcohol like I used to either! It's a total different ball game than the SSRIs I've tried! I'm grateful :-)"

Was this helpful?YesNo
182 Report
  • AnonI...
  • July 18, 2013

"I just took the first 100mg pill a few hours ago and I feel different. I feel almost normal. I'm not thinking about being depressed, and my energy is almost back to normal. No antidepressant, antipsychotic, or mood stabilizer has ever done that! If this feeling keeps up or gets better, I don't know what I'll do. I'll probably cry tears of joy. Is this what normal people feel like?"

10 / 10
Was this helpful?YesNo
184 Report
  • c3lla...
  • May 16, 2013

"This medicine really works for me and has really improved my quality of life and perspective on things. I'm 18, and I have been on this for a little over 6 months, and I would say the only bad side effect is dry mouth, but if you just drink a lot of water, you'll be fine. I like it because it has helped me stop 'binge' eating. I don't have cravings for food or cigarettes anymore, and I completely stopped smoking. I'm never tired anymore; Wellbutrin definitely gives you energy in a good way. Sex drive is completely normal, and I still have normal emotions, unlike when I was on Celexa or Prozac where I felt so emotionless. I lost 20 lbs, but I am healthy and fit and a lot happier with myself."

9 / 10
Was this helpful?YesNo
183 Report
  • Augus...
  • Taken for 1 to 6 months
  • January 13, 2020

"Having fallen into a serious depression which led me to have great difficulty in doing everyday things, getting up in the morning, brushing my teeth, washing, and also couldn't get important sleep. It was getting really difficult. My neurologist prescribed Wellbutrin XR 150mg once a day in the morning. I was very hesitant to take the drug for fear of the side effects. Today, after 3 months of treatment, I sincerely thank her. I have found energy, reconnected with my social relationships, etc. In terms of side effects for me, it's mild: dry mouth, a few palpitations often at night, and slight weight loss. In 3 months of treatment, I lost 4 pounds."

8 / 10
Was this helpful?YesNo
90 Report
  • Anonymous
  • March 18, 2010

"I have been taking Wellbutrin continuously for 20 years. If it were not for this miracle drug, I would be dead. There is no doubt in my mind that my intractable depression was arrested with Wellbutrin. I have a chemical imbalance that is permanent. I once went off Wellbutrin for a month because I was taking another medicine. Within three weeks, I was having suicidal ideas. Needless to say, I will not go off it again. My doctor assures me it is safe for lifelong use."

10 / 10
Was this helpful?YesNo
213 Report
  • Lannahn
  • Taken for 1 to 6 months
  • May 25, 2019

"The heightened sex drive Wellbutrin (bupropion) is so powerful that I'm even having awesome sexual dreams in my sleep. It hasn't helped me to stop smoking, but I smoke very little to begin with, so maybe that's why I don't notice a difference. It totally smoothed out my mean mood swings. I just love it. I have zero bad side effects. I do believe the medication helps females' libido more than it helps most males, but I could be wrong."

10 / 10
Was this helpful?YesNo
98 Report
  • samban
  • Taken for less than 1 month
  • June 8, 2023

"I took two doses of 150XL bupropion, on the second dose I have immediate ear ringing, fullness, and pressure in my ears. I’ve never once had an issue with my ears in my life. I’m very young and healthy. Months later and after multiple ENTs, I have permanent tinnitus from this drug. It shouldn’t be legal."

1 / 10
Was this helpful?YesNo
31 Report
  • thank...
  • Taken for 1 to 2 years
  • October 21, 2018

"I have been taking Celexa for a while to treat depression, and while helpful, it had made me very numb, and I was still feeling occasional episodes of mild depression. My provider added Wellbutrin, and what a difference! Wellbutrin gave me a boost of mental energy and feelings of well-being that I had never felt before. I am currently doing very well with the combination of Celexa and Wellbutrin. I feel better than I ever have in my life. I've been on this fantastic combination for a year. Highly recommend."

10 / 10
Was this helpful?YesNo
102 Report
  • Skarg...
  • July 19, 2015

"Y'all! I am one of these people who cannot say enough about bupropion! It has changed my life after only day 8. Such a subtle but powerful shift in perception and decrease in troublesome habits (smoking one of them, but also irrational anxiety getting on train, rushing down the street for no reason, rushing through dinner) has decreased by drinking, made me feel less weighed down. There are side effects the first few days, but they will go away! Stick with it, and you won't regret it."

10 / 10
Was this helpful?YesNo
141 Report
  • Sammy...
  • Taken for less than 1 month
  • October 31, 2015

"I'm in my early 40s and have noticed the last couple of years I've become very agitated over nothing! Always yelling at my teenager and I could literally feel my blood pressure raising over the smallest things. Also this last year for some reason I became depressed. I didn't ever want to get out of bed or leave the house to do anything. I've always had a bad opinion about antidepressants, but I knew SOMETHING had to change. I reached out to my doctor who gave me 100 mg of generic Wellbutrin, and the very first day I noticed I was calmer! I fell asleep 2 hours later but woke up refreshed. I just finished day 3, and I swear I feel fantastic! Not only have I not yelled even once, I don't feel angry at all! And I want to do stuff again. Very happy"

9 / 10
Was this helpful?YesNo
137 Report
  • AKTso...
  • September 2, 2013

"The first time I took Wellbutrin I was in the hospital for major depression, suicidal ideation, and a nervous breakdown. After trying the typical Zoloft, Paxil, and others, the doctors were running out of options. A new doctor on staff gave me Wellbutrin (I don't remember the dose) and I instantly was transported to a state I can only describe as ecstasy. Unfortunately, this lasted only one day, probably because of my 'virgin' brain. But staying on this med for two years helped me recover my life. I am so grateful. This was 15 years ago, and although I still suffer from major depressive disorder, I have been able to get a Master's degree and a new career."

5 / 10
Was this helpful?YesNo
160 Report
  • winni...
  • Taken for 1 to 6 months
  • June 5, 2014

"Wellbutrin is amazing. Prior to Wellbutrin, I was put on Zoloft, Prozac, and Valdoxan, all of which either killed my sex drive, did nothing, or made me too sleepy to function. For 2 years, I stupidly went off medication and just thought everything in life was crap, and probably said some things I regret to people. Eventually, it came to the point where I was failing at work and angry at everyone. The ADHD medication I was taking also worsened my depression. With Wellbutrin, I have been on it for around two months, and I feel great. I have energy, more motivation, increased libido, and I feel content, although I still have moments. Also, I have lost more than 5 pounds without dieting or exercising."

10 / 10
Was this helpful?YesNo
148 Report
  • CanlasT
  • August 20, 2015

"All I can say is Wellbutrin has substantially increased my quality of life. I was so scared about side effects that I waited years to try antidepressants. I was on Celexa, and when that failed, I was put on Zoloft, which also did me no good. Wellbutrin not only brought me out of a deep depression, it's caused me to be active, and my weight is now in the normal range. I'm also more organized and positive than I've ever been. My family members, who were initially against me taking Wellbutrin, have changed their opinion because they see me enjoy life again."

10 / 10
Was this helpful?YesNo
134 Report
  • pwnvi...
  • Taken for 1 to 6 months
  • January 25, 2016

"I was prescribed Wellbutrin by my doctor when I told her that I was having a very difficult time getting out of bed and wanting to be productive one month ago. My doc prescribed me Wellbutrin 150 xl, which has as an added bonus made me completely stop smoking and even become repulsed by cigarettes. No negative side effects. Wellbutrin has reduced my urge to drink alcohol by 90%, and when I do drink, I feel intoxicated after only 2 or 3 drinks. I have been exercising five days a week and eating well to assist in mood elevation. I have more motivation and energy now than a month ago. I am impressed with this medication."

10 / 10
Was this helpful?YesNo
129 Report
  • Anonymous
  • July 23, 2008

"I have been taking Wellbutrin for almost a month now and I have already noticed a change. I used to be this really upbeat, happy, positive person, and all of a sudden, I was tired all the time, couldn't sleep, was really sad all the time, agitated really easily, and also got snippy with people at the drop of a hat. My mom was the one who said I needed to go see the doctor and find out what was going on with me. I've tried other antidepressants; this is the only one that works for me."

10 / 10
Was this helpful?YesNo
205 Report
  • Anonymous
  • June 18, 2009

"I have recently decided to start Wellbutrin after 2 years on Zoloft. Although I felt the Zoloft worked well, there were some unfortunate side effects. I asked my doctor if I could give Wellbutrin a try (I had also recently picked up smoking again so I mentioned that). Well, here's the good news... my mood has remained stable (I simultaneously tapered off the Zoloft). I have been better able to focus at work, cigarettes tasted disgusting, and I have noticed a decrease in my desire to engage in compulsive activities. The cons... food doesn't really taste all that great, I'm extremely thirsty, and I was initially a little on edge at first (this has since gone away). The other surprising effect was a marked improvement in sexual response."

9 / 10
Was this helpful?YesNo
193 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.