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Benzoyl peroxide / clindamycin topical and Acne: What Users Say

Brand names: Benzaclin, Duac, Onexton, Acanya, Neuac, Z-Clinz 10

Acne: mentioned by 22 users (3.8%)

Based on user experiences from 576 Benzoyl peroxide / clindamycin topical reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dryness 24.0%
dry skin 15.1%
peeling 12.2%
burning 11.8%
itching 11.1%
redness 10.2%
acne 3.8%
pain 3.0%
stinging 3.0%
swelling 2.6%

Reviews for Benzoyl peroxide / clindamycin topical

Commonly mentioned side effects
  • loz...
  • Taken for 1 to 6 months
  • September 16, 2013

Benzoyl peroxide / clindamycin topical for Acne "I'm 26 and have suffered with acne since my early teens. Sometimes mild, other times I've not wanted to walk out the door. In recent years, I've been diagnosed with polycystic ovary syndrome, which has a side effect of acne. After years of trying so many creams, washes, old wives' tales, etc., my doc finally gave me Duac! AMAZING! My chin was severely swollen with spots that were red raw. After a week of use, it was like a miracle! If I could upload my pics, I so would. My skin was near perfect. I now use Duac along with the Proactiv 1, 2, 3 kit, and my skin has never looked so good. I even get so many compliments, and I feel confident now. I highly recommend! Good luck!"

10 / 10
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33 Report
  • MSY...
  • Taken for less than 1 month
  • January 3, 2021

Benzoyl peroxide / clindamycin topical for Acne "Terrible cream! Before Duac, I didn’t have textured skin, fine lines, pore issues, or dryness. I could use anything without it clogging pores or causing acne. However, I do struggle with minor breakouts on my forehead and cheeks. My skin is fine most months but acts up, so I was put on Zinerty. Zinerty is good, but spots would always reappear. When I first started using Duac, I broke out, tiny little spots all over my face. I didn’t get much help from the doctors either. My skin hasn’t been the same since. I've noticed tiny fine lines near the corners of my forehead, textured skin, something which I didn’t have before, dry, and overall not the same. I used to break out and the scars would fall off, marks would go by themselves, but now, I have scars, marks, etc. Please be careful. If you’re suffering with minor breakouts, not full-blown acne, look into things before you decide to go ahead with Duac."

1 / 10
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18 Report
  • Ame...
  • August 16, 2015

Benzoyl peroxide / clindamycin topical for Acne "I've been using this product for about two years, and it produces miracles. I used it, and right away everything cleared up. About a year after using this product, I went away for two weeks and kinda got off it. I had a huge breakout, and in my opinion, a disgusting one. I went back to the product, and after a week, started crying after seeing the results. This is magnificent."

10 / 10
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14 Report
  • Jes...
  • January 4, 2014

Benzoyl peroxide / clindamycin topical for Acne "I used Duac after being prescribed it for a good six months (on repeat prescription). To begin with, my skin flared up bright red, and it dried my skin out terribly. I then reduced the amount I was using from the fingertip amount, which is recommended on the box, to the merest bit on each area of acne. This worked a treat, and within 2-3 weeks, my skin was looking much better. Over the next 6 months or so, my skin improved, and I only had a small breakout once in a while. However, I felt that after using it for 6 months, my skin had become accustomed to it, and I was having more and more breakouts. I stayed off the cream for a good four months. I am now back on the cream, and going through the phase of the skin drying out, etc."

8 / 10
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16 Report
  • esa...
  • Taken for 6 months to 1 year
  • February 14, 2019

Benzoyl peroxide / clindamycin topical for Acne "This stuff is the BEST! I have suffered with acne for years. Really painful under-the-skin cystic acne that has literally brought me to near tears, it hurt so bad. I tried everything, and nothing ever worked. This was the last option I had to try before my dermatologist went forward with cortisone shots and Accutane as a last resort. I have been using Onexton once a day for 6 months now, and I haven't had a cystic pimple in about 5 months! Or any pimple for that matter, besides the one occasional tiny pimple that you can't see, and hardly anything comes out. Gone by morning with Onexton! My skin is so clear and smooth, I love it. The only 2 downsides are the first month, it made me break out a little more than usual as it was trying to get rid of the acne rather than maintain a clear face like now. The other downside is it does make you dry, but as long as you exfoliate once or twice a month and use a good moisturizer, you should be square. I am so happy my dermatologist had me try this!"

10 / 10
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7 Report

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  • Anonymous
  • November 16, 2015

Benzoyl peroxide / clindamycin topical for Acne "I've been using this medication for over a week now, and it's made my skin extremely dry. I can't apply foundation without it looking patchy, regardless of the amount of moisturizer I use morning and night alongside primer. It's broken my face out with pimples. I didn't even have pimples to start off with-the medication was for scarring. I am so disappointed with this because it's further spoiled my skin."

1 / 10
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16 Report
  • Amy...
  • December 7, 2016

Benzoyl peroxide / clindamycin topical for Acne "I was diagnosed with PCOS (Polycystic Ovary Syndrome), and my spots were horrible on my face, back, and shoulders. Since I've been using Duac - once every two days as told by my GP, my confidence is returning. I don't feel the need to wear makeup all the time. All I now have are some acne scars on my chin and back, which will clear up in time. I give my body a week to two weeks off at the 12-week cycle and restart as my hormones release the spots again. Don't know what I'd do without Duac!!!"

10 / 10
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7 Report
  • Ten...
  • Taken for less than 1 month
  • August 18, 2018

Benzoyl peroxide / clindamycin topical for Acne "I have always had oily skin, but I've never had acne before-not even as a teen. However, over the last few months, I developed a persistent rash on one side of my face. I also had painful non-puss-filled spots, and my skin looked terrible! (Upon reflection, I think it was my use of apple cider vinegar.) Anyway, nothing worked. I went to the doctor, and he prescribed Duac. I have used it once, and I can already see/feel the difference. I had a brown pimple/skin tag, and that's more or less halved overnight. The other spots that I had are also less painful. I'm so excited to see what my skin will look like after 2 weeks (I've been told to use it for this long)."

9 / 10
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5 Report
  • Lon...
  • June 24, 2015

Benzoyl peroxide / clindamycin topical for Acne "I'm 24 and have been using Acanya since I was 18. I remember noticing a difference within the first few days and massive improvement within a few weeks to 1 month? Don't really remember, however, this product has remained relatively effective for 6 years for me. Skin is 90% clear other than cysts when I am highly stressed or due to hormones. This medication only gets 9/10 because I still get blackheads and cysts occasionally, and it's very expensive."

9 / 10
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6 Report
  • Dan...
  • Taken for 1 to 2 years
  • February 27, 2019

Benzoyl peroxide / clindamycin topical for Acne "This product works so well and worked wonders for 2 years or more, I think. Anyhow, 2 months ago, I just started to break out really badly after a month that I stopped using it. It’s pricey as !!! But I didn't mind the price. Now I’m on Finacea gel 15% because my doc said that my body built resistance to Benzaclin. It just stopped working. The reason for my review being good is because it worked great for years, but now it's time to move on to something stronger. I advise anyone to jump on this and wait for results at least for a month. I had cystic acne and lots of them then and now, but pray for me with my next set of medicine!"

8 / 10
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2 Report
  • Amh...
  • Taken for less than 1 month
  • November 11, 2022

Benzoyl peroxide / clindamycin topical for Acne "Been on Duac for 2 weeks, have noticed my acne worsening. Wondering if the product isn’t for me. Waking up with more spots every day. On my head and chin, quite painful. Wondering if it’s just making it worse, if I should stop or persist."

5 / 10
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1 Report
  • Amh...
  • Taken for less than 1 month
  • November 11, 2022

Benzoyl peroxide / clindamycin topical for Acne "Been on Duac for 2 weeks, have noticed my acne worsening. Wondering if the product isn’t for me. Waking up with more spots every day. On my head and chin, quite painful. Wondering if it’s just making it worse, if I should stop or persist."

5 / 10
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1 Report
  • Fay...
  • Taken for less than 1 month
  • January 28, 2019

Benzoyl peroxide / clindamycin topical for Acne "Amazing! Took a course of vitamin B12 in a high dose, which caused awful acne (I don’t get acne).... I’m on day 3, and it’s pretty much gone! This product is drying, and you do need to bear in mind with all benzoyl peroxide products. I’d been using Acnecide prior to trying Duac, so my skin was already used to it, so I didn’t get any side effects, particularly other than my skin feeling a bit tight. However, if you do start this medication, power through! Maybe take a day’s break here, and you’ll thank yourself for persevering."

10 / 10
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2 Report
  • Ang...
  • April 28, 2019

Benzoyl peroxide / clindamycin topical for Acne "I spent over $100 for Onexton to completely destroy my skin. Do not use this if you have sensitive skin. It made my skin so dry and sensitive that I caused more breakouts. I have disfiguring scars from the cystic pimples that Onexton caused. I stopped using this six months ago, and my pores are still large, my skin is red, and since my skin is so sensitive, I constantly have breakouts that I can’t do anything to prevent since topicals could cause further damage. This is definitely one of my worst decisions."

1 / 10
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4 Report
  • Aly...
  • Taken for 1 to 6 months
  • March 31, 2018

Benzoyl peroxide / clindamycin topical for Acne "I've never had bad acne on my face, but I got some inflammation on my shoulders. As I got older, it started to fix itself, but I wanted something to help it along a little. I went to the doctor's and was prescribed Duac. Due to my pale skin, I was given a slightly weaker version of the gel. As expected, I had dry and itchy skin, but it passed. My shoulders became clearer, but I noticed that my face hadn't improved at all, it seemed to have gotten worse. It caused me to have a breakout on my chin that, two weeks on, still hasn't cleared up. I only apply it to my cheeks and chin, but noticed that I was getting small red lumps on my forehead. My skin has turned really red, and it seems like the irritation that you experience when you first start using this gel has returned. I have read the reviews and comments here saying that people could see improvements within several weeks to a month, but I've seen no change and it appears as though I'm just wasting my breath with this product."

3 / 10
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2 Report
  • Kat...
  • Taken for 1 to 6 months
  • September 18, 2018

Benzoyl peroxide / clindamycin topical for Acne "This medication is terrible. I had only a bit of acne when my GP recommended this. Taking this was the worst decision of my life. It made my acne only slightly better, but in exchange, I got extremely red, flaky, painful skin. Therefore, I decided to stop using it entirely in hopes that my skin would go back to normal. This drug works by killing all the bacteria on your skin, both good and bad (I hadn’t done my research or known this at the time). So when I quit using it, my skin had no good bacteria left to defend against the bad, resulting in the worst breakout of my life. I now have cystic acne on my cheeks, forehead, and chin. My skin has never looked this terrible in my entire life (I normally have clear skin). I’m warning anyone out there with moderate acne and sensitive combination skin: DO NOT USE THIS. If you’re looking for clear skin, there are better solutions out there. Please save yourself the heartache."

1 / 10
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10 Report
  • Ski...
  • Taken for 2 to 5 years
  • March 2, 2016

Benzoyl peroxide / clindamycin topical for Acne "Acanya worked amazingly on me for two years. I had moderate acne around my mouth, chin, and all over my forehead. Acanya started working immediately (never even got the initial breakout), and within 2-3 months, my skin was completely clear. People were actually complimenting me on my complexion! However, after two years, Acanya was no longer effective. My skin is not nearly as bad as it used to be as a teenager (I'm 23 now), but I still get breakouts on my forehead and chin when I'm about to start my period. Since Acanya no longer works, my dermatologist has recently prescribed me Epiduo, which is benzoyl peroxide and adapalene. Fingers crossed that Epiduo works as well as Acanya did!"

8 / 10
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1 Report
  • fjv...
  • Taken for 6 months to 1 year
  • February 26, 2018

For Acne "(Use VANI Cream as a moisturizer!) I started using this stuff along with tretinoin every day when I was 14 because of my hormonal acne, it completely cleared my skin. After about 6 months, I thought my skin was good enough and I stopped using it, but then after 3 months, my acne came back but worse, with deep bright red cystic acne on my cheeks, chin, and forehead. I started using it again, and my skin broke out SO BAD because it was pulling out all the deep-rooted acne, but after a harsh month, I saw results all at once. For people who can't find a moisturizer, USE VANI CREAM!! (for sensitive skin) This stuff is very strong but doesn’t interact with the medicine to make it burn, it’s also not greasy and prevents flaking."

7 / 10
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1 Report
  • Kic...
  • Taken for less than 1 month
  • December 15, 2020

Benzoyl peroxide / clindamycin topical for Acne "Been on this for around 2 weeks, and all it's done is make my acne worse. Now I have double the acne. The worst part about it, I had to pay £45 for this 60g tube...basically paying for more acne...don't bother."

2 / 10
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3 Report
  • Dua...
  • Taken for less than 1 month
  • May 2, 2020

Benzoyl peroxide / clindamycin topical for Acne "I was prescribed Duac gel by my doctor, and it definitely did not work. I get the hormonal pimple here and there, and I generally have really good skin. However, after I used the Duac gel, my face broke out a week later. I now have painful, cystic acne that is getting worse every day. My doctor said it was a reaction to the cream and to stop immediately. Still waiting to see any signs of improvement after a week of not using."

1 / 10
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10 Report
  • Bwt...
  • Taken for less than 1 month
  • December 7, 2018

Benzoyl peroxide / clindamycin topical for Acne "It increased the acne, maybe this is the purging phase and it is getting rid of trapped inflammation inside. I don't know, but my skin is getting worse."

1 / 10
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9 Report
  • Anonymous
  • May 12, 2018

Benzoyl peroxide / clindamycin topical for Acne "Was good for a year, and my face broke out after that."

8 / 10
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7 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.