Benzoyl Peroxide / Clindamycin Topical Dosage

Medically reviewed by Drugs.com. Last updated on Jul 31, 2023.

Applies to the following strengths: 5%-1%; 5%-1.2%; 3.75%-1.2%; 2.5%-1.2%; 5%-1.2% with emollients; 10%-1%

Usual Adult Dose for Acne

Benzoyl peroxide 2.5 %-clindamycin 1.2%: Apply a pea-sized amount topically to the face once a day

Duration of therapy: Use beyond 12 weeks has not been evaluated

Benzoyl peroxide 3.75%-clindamycin 1.2%: Apply a pea-sized amount topically to the face once a day

Duration of therapy: Use beyond 12 weeks has not been evaluated

Benzoyl peroxide 5%-clindamycin 1%: Apply topically to the face twice a day, in the morning and evening or as directed

Benzoyl peroxide 5%-clindamycin 1.2%: Apply a thin layer topically to the face once a day in the evening or as directed

Comments: Skin should be thoroughly washed with a mild soap, rinsed with warm water, and gently dried prior to application.

Use: For the topical treatment of acne vulgaris

Usual Pediatric Dose for Acne

12 years or older:
Benzoyl peroxide 2.5 %-clindamycin 1.2%: Apply a pea-sized amount topically to the face once a day

Duration of therapy: Use beyond 12 weeks has not been evaluated

Benzoyl peroxide 3.75%-clindamycin 1.2%: Apply a pea-sized amount topically to the face once a day

Duration of therapy: Use beyond 12 weeks has not been evaluated

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

Hypersensitivity to clindamycin, benzoyl peroxide, lincomycin, or to any components of this formulation
History of regional enteritis, ulcerative colitis, pseudomembranous colitis, or antibiotic-associated colitis

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

For topical use only; not for oral, ophthalmic, or intravaginal use.
Contact with mouth, eyes, lips, other mucous membranes, or irritated or broken skin should be avoided.
Concomitant topical acne products should be used with caution due to possible irritant effect, especially with use of peeling, desquamating, or abrasive agents.

Storage requirements:
Benzoyl peroxide 2.5 %-clindamycin 1.2%:
Prior to dispensing: Store in refrigerator at 2C to 8C (36F to 46F); dispense with 10 week expiration date
After dispensing: Store at room temperature at or below 25C (77F); protect from freezing; keep tightly closed.

Benzoyl peroxide 3.75%-clindamycin 1.2%:
Prior to dispensing: Store in refrigerator at 2C to 8C (36F to 46F); dispense with 10 week expiration date
After dispensing: Store at room temperature at or below 25C (77F); protect from freezing; store pump upright.

Benzoyl peroxide 5%-clindamycin 1%:
Reconstituted: Can be stored at room temperature up to 25°C (77°F) for 3 months; place a 3 month expiration date on the label immediately following mixing.; keep tightly closed; do not freeze.

Benzoyl peroxide 5%-clindamycin 1.2%:
Prior to dispensing: Store in refrigerator at 2C to 8C (36F to 46F); dispense with a 60 day expiration date
After dispensing: Store at room temperature up to 25C (77F); protect from freezing; keep tube tightly closed.

Reconstitution/preparation techniques:

Benzoyl peroxide 5%-clindamycin 1%: Tap vial so powder flows freely and add indicated amount of purified water to the mark on the vial and immediately shake to completely dissolve drug; if needed, add additional purified water to bring level up to the mark. Add the solution in the vial to the gel and stir until homogenous in appearance; if this drug is dispensed in a pump, reassemble jar with pump dispenser.

Patient advice:

Discontinue use and contact your physician immediately if allergic reactions, including severe swelling or shortness of breath, occurs.
Irritation, including erythema, scaling, itching, or burning may occur when used in combination with other topical acne products.
Exposure to sunlight and sunlamps should be avoided or minimized; if this is not possible, sunscreen and protective clothing should be worn.
Avoid contact with hair, fabrics, furniture, or carpeting as this drug may bleach hair and color or dye fabrics.