Thrombotic Thrombocytopenic Purpura

Medically reviewed by Drugs.com. Last updated on Apr 6, 2025.

• Care notes
• Aftercare
• Ambulatory
• Discharge
• Inpatient
• Español

TTP is a blood disorder that causes anemia and bleeding problems due to low platelet levels. Anemia is low levels of red blood cells. Without enough platelets, you can bleed in your organs, underneath your skin, or from the surface of your skin. TTP can also cause problems with kidney and brain function.

WHILE YOU ARE HERE:

Informed consent

is a legal document that explains the tests, treatments, or procedures that you may need. Informed consent means you understand what will be done and can make decisions about what you want. You give your permission when you sign the consent form. You can have someone sign this form for you if you are not able to sign it. You have the right to understand your medical care in words you know. Before you sign the consent form, understand the risks and benefits of what will be done. Make sure all your questions are answered.

You may need extra oxygen

if your blood oxygen level is lower than it should be. You may get oxygen through a mask placed over your nose and mouth or through small tubes placed in your nostrils. Ask your healthcare provider before you take off the mask or oxygen tubing.

Monitoring:

• A heart monitor is an EKG that stays on continuously to record your heart's electrical activity.
• A pulse oximeter measures the level of oxygen in your blood.
• A neurological exam , or neuro checks, show healthcare providers your brain function. It will also help them check for a stroke that could be caused by TTP. They will check how your pupils react to light. They may check your memory and how easily you wake up. Your hand grasp and balance may also be tested.

Medicines

may be given to control how much your blood clots.

Drugs used to treat this and similar conditions

IV fluids

may be given to increase your blood pressure. IV fluids are needed if TTP causes heavy bleeding.

Tests:

• Blood and urine tests are used to measure your blood cell levels and kidney function.
• A CT scan is used to check for clots or bleeding in your brain.

Treatment:

• A plasma or blood transfusion can help increase platelet and red blood cell levels.
• Plasma exchange is a procedure that removes antibodies from the blood. This procedure can help improve your platelet levels and control how your blood clots.
• Surgery to remove your spleen may be needed if your TTP is severe.

Treatment options

The following list of medications are related to or used in the treatment of this condition.

• Cablivi
• Adzynma
• apadamtase alfa, recombinant
• caplacizumab

RISKS:

Thrombotic thrombocytopenic purpura (TTP) can cause kidney failure, stroke, or heart attack. It can also cause heavy bleeding in the brain or intestines. These conditions can be life-threatening.

CARE AGREEMENT:

You have the right to help plan your care. Learn about your health condition and how it may be treated. Discuss treatment options with your healthcare providers to decide what care you want to receive. You always have the right to refuse treatment.

© Copyright Merative 2025 Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer