Linzess - How long before it starts working?

In the past for over 50 years i have had severe constipation and lots of hospital visits from diverticulitis. A few years ago, i began using 'Miralax' (costco brand-cheaper) and have not had any bouts of constipation since!!! however, recently i have struggled with severe bloating and stomach cramps which are NOT due to diverticulitis this time. GASTRO prescribed Linzess as he felt my bowels did not empty properly. i have taken it for 2 weeks now. the KEY is to take it first thing in the morning with LOTS OF WATER! and before eating anything for half hour. i drink water all morning and begin bowel movements within half hour to an hour afterwards. it does give me slight diarrhea but does not last long. pains have let up and bloating is much better. so mine started right away the first dose. I Do continue the Miralax every day as well. it was a life saver. not sure why the bloating started but Linzess seems to help.

I also have chronic constipation it has been 6 months since I’ve had a solid firm bowel movement and I’ve tried everything. I finally went to my Gastro doctor and he prescribed Linzess 145 mg once daily. It’s been 12 days since I’ve started the medication. After 9 days and a lot of stomach pain I did have One medium size BM, but there’s so much more to get out so I continue with my daily dose hoping I will go again. As time goes on I continue to be completely bloated especially when I have food and very gassy. The nausea has lifted a lot but not completely. I will wait 3 more days and if I don’t release another bowel I will get on a higher dose.

My doctor prescribed Linzess 145 mg after I required a fecal impaction removed at the emergency room. Experienced relief after several days and I take it first thing in the morning. Within two hours I have a very loose stool but not an uncomfortable diarrhea. After six weeks I begin taking it every other day and then every third day with adequate results.

I took my first dose of 290mcg's yesterday at 10am and today for the first time in a decade I did not have severe constipation with pain. All the literature says it takes a week to start working... I hope this isn't a bad sign that it started working so quickly... I hope this isn't the start of severe diarrhea... so far amazing... almost too hard to believe after a decade of suffering.

I started linzess 3 years ago And it worked right away. I had diarrhea two hours after taking it. It worked for a while but now I’m taking 290 mg and take up to three a day for a week and still haven’t had a bowel movement. Before Linzess I would go to to three weeks without a bowel movement

I had severe constipation for years and I tried everything but nothing works!! nothing so I start looking for natural food to see if it could help and after trying the different food here what works for me!! I put 5 prunes in a large cup of water and leave it overnight. I drink the water and eat the prunes on empty stomach in the morning and after 8 hours I get relief. it's magic. if you try everything and you still having a problem just give it a try. I hope this helps like it help me!! I used to cry in the bathroom every day to get relieved but now after this ancient receipt, I am a very happy person!! good luck and please share if this helped you!!

I am not sure I just started taking it

I think Luma1 has got great advice and I am going to expand on what else can help as I to am a sufferer the body as I understand it is like a plumbing system but a bit more complex so that water and hydration is vital in this process as this medicine is relying on taking fluids from your body and forcing them down the drain to encourage the flush. So with that being said if you can keep your body more hydrated then the medicine has a higher success rate because you have given it the tools to work the way it was designed. Adding fiber and prunes is great they are the natural products our body likes to use but sometimes those aren’t great for all of us so. Good luck to everyone.

Well the doctor put me on 290 mg of linzess it does not work at all I've been on it 7 days nothing so he told me to take some bowel suppositories so I'm going to try those this evening how long are you supposed to take this stuff in your gut till it begins to work that's the strongest dose you would have seen something by now I'm 78 years old and I'm miserable feel like I have to go but this
Strain
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is just too much it gives me poundingheadaches

Always I had difficulty going to the bathroom, but after I had surgery in my colon everything got worse. My bowel movements had stopped completely. I began to take all kind laxatives. I had a lot of cramps, bloating, discomfort and I could barely pass anything . It was a nightmare. Than my GI prescribed me Linzess 145 mg. It took several days to start to work. I almost gave up. I am talking about 2-3 weeks. Finally it began to work and I don't have any cramps, nothing. I don't even take it everyday day anymore ( just when things are getting difficult). I take it first thing in the morning with a big cup of water. Begin to fix my kids breakfast and other things, meanwhile I still sipping water. After 45-1hr I eat my breakfast. Sometimes I have a bowel movement in a 30 minutes other times more. Couple times it didn't work, so I did the same routine next day and it works. I am really happy that I found this drug because I was suffering so much with my constipation.

I'm a 67 years male with chronic constipation. Been taking 145 mg for 30 days. Experienced relief after taking in 2 days. I always take it near 6:00am with a large glass of water. I then eat at 7:00am (usually toast/coffee). I have a "normal BM" within 30 minutes. Then have a smaller BM about an hour later. Now After 30 days, I'm experiencing loose stool. I am now experimenting with taking the drug every other day. Occasionally I have experienced cramping & discomfort during the day.

It took me at least 4 or 5 days at first to work . Also, if you are still having issues , my dr. told me to take a non-stimulant stool softener along with it. I take the stool softener at night before I go to bed , than I take Linzess ( I did have to move up eventually to the 290's ) when I wake up in the morning. I drink at least 1 bottle or 2 cups of WARM water when taking it. I then find relieve within 30 minutes most days.

I began taking Linzess 2 months ago and in the beginning thought it was the silver bullet. My physician initially prescribed 145mcg and then increased my dosage to 290mcg. At the initial start of each therapy I thought it was going to work but then stopped. I have been reading additional information and comments from others and did find that one patient was having better success taking Linzess after a breakfast with some fat. The patient began this administration due to the information in the Linzess material that stated in cross trials patients who took the Linzess after a high fat breakfast had looser bowel movements. I plan to try this to see if it will work before I have to resort back to laxatives..

I understand completely ! I started with the 290, but it was too strong. I take the 145. Here's what I found that works not always the same but close.

Wake up. Drink a bottle or glass of water. Take Linzess. Drink some more water. Wait 30 mins. Eat. Stay on the same schedule each day. Meaning don't take it one morning and then the next afternoon, then lunch then... If i follow this routine I've learned that I don't even have to take it daily. I am also half way insomniac so taking it at night keeps me up... Hope this helps. This was trial and error from my Zelnorm days and it works...